pou5f3

ID

ZDB-GENE-980526-485

Name

POU domain, class 5, transcription factor 3

Symbol

pou5f3 Nomenclature History

Previous Names

• oct4
• pou2 (1)
• pou5f1 (1)
• cb197 (1)
• chunp6868
• etID49452.21 (1)
• gp-9
• gp9
• spg
• spiel ohne grenzen
• spiel-ohne-grenzen (1)
• wu:fd18d06

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Description

Exhibits several functions, including DNA-binding transcription factor activity; chromatin binding activity; and protein heterodimerization activity. Involved in several processes, including brain development; embryonic morphogenesis; and regulation of nucleobase-containing compound metabolic process. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in embryonal carcinoma and seminoma. Is expressed in several structures, including blastoderm; blastodisc; ectoderm; gonad; and hindbrain neural keel. Orthologous to human POU5F1 (POU class 5 homeobox 1); POU5F1B (POU class 5 homeobox 1B); and POU5F2 (POU domain class 5, transcription factor 2).

Genome Resources

• Alliance (1)
• Gene:30333 (1)
• VEGA:OTTDARG00000032106 (1)
• Ensembl(GRCz11):ENSDARG00000044774 (1)

Note

The gene name was updated on May 20, 2013 to reflect the evolutionary relationship of this gene with the mammalian POU domain, class 5 genes. The data suggests that there is not a true ortholog in human and mouse for this zebrafish gene. The synteny, amino acid alignment and phylogenetic trees suggest that a duplication event occurred in the last common ancestor of extant cartilaginous fishes and bony fishes resulting in 2 POU5 genes. Subsequently, the bony fishes, marsupials and birds maintained pou5f3, but lost pou5f1 which was maintained in eutherians and marsupials. This gene is an apparent ortholog (AA, CL) with the opposum, xenopus and chicken Pou5f3 genes.

Comparative Information