Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-980526-416
Gene Name: wingless-type MMTV integration site family member 2
Gene Symbol: wnt2
Previous Names: ZfWnt2 (1), etID309852.18 (1)
Nomenclature History
GENE EXPRESSION
All Expression Data: 11 figures from 5 publications
Directly Submitted Expression Data: 7 figures (11 images) from Thisse et al., 2004 [MGC:65730]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
  neural tube, neuron, optic vesicle, otic vesicle (all 8) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 2 genotypes
Alleles: hu2847, hu2848
Knockdown reagents: MO1-wnt2 (1), MO2-wnt2 (1), MO3-wnt2 (1)
PHENOTYPE
Data: 3 figures from Poulain et al., 2011
Observed in: cell proliferation, liver, liver development, pancreatic B cell (all 6) expand
GENE ONTOLOGY
Ontology GO Term
Biological Process liver development (more)
Cellular Component extracellular region (more)
Molecular Function receptor binding (more)
GO Terms (all 20)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR005817 (1)
  • InterPro:IPR009140 (1)
  • InterPro:IPR018161 (1)
  • PROSITE:PS00246 (1)
  • Pfam:PF00110 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA wnt2-001 (1) 1509
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM wnt2
    Tg(hsp70l:mCherry,wnt2)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    wnt2 Contained in: [BAC] CH211-238N5 (1) (order this), DKEY-270I2 (1) (order this)
    wnt2 Contains: [SNP] rs3728908 (1), rs3728909 (1)
    wnt2 Encodes: [cDNA] MGC:65730 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_130950 (1) 1509 bp
    Genomic GenBank:DP000237 (1)
    Polypeptide UniProtKB:Q92048 (1) 350 aa
    Sequence Clusters UniGene:378 (1)
    Sequence Information (all 18)
    OTHER wnt2 GENE PAGES
  • Gene:30127 (1)
  • VEGA:OTTDARG00000013718 (1)
  • Ensembl(Zv9):ENSDARG00000041117 (1)
  • MAPPING INFORMATION
    Chr: 18 Details View Map: Merged   Individual Panels
    ORTHOLOGY
      Evidence
    Species Symbol Chromosome (Position) Accession # AA
    Zebrafish wnt2 18  
    Human WNT2 7 (7q31.2)
  • OMIM:147870
  • Gene:7472
  • Mouse Wnt2 6 ( 8.08)
  • MGI:98954
  • Gene:22413
  • CITATIONS (30)