ZFIN ID: ZDB-PUB-961107-1
Three Wnt genes expressed in a wide variety of tissues during development of the zebrafish, Danio rerio: developmental and evolutionary perspectives
Blader, P., Strähle, U., and Ingham, P.W.
Date: 1996
Source: Development genes and evolution   206(1): 3-13 (Journal)
Registered Authors: Blader, Patrick, Ingham, Philip, Strähle, Uwe
Keywords: Wnt, Zebrafish, Viscera, Brain, Neural tube, Tailbud, Presomitic mesoderm
MeSH Terms: none
PubMed: 24173392 Full text @ Dev. Genes Evol.
Proteins encoded by the Wnt family of genes act as signals and have been shown to play important roles in a wide variety of developmental processes. Here we describe the cloning of three Wnt family members from the zebrafish, Danio rerio, which encode proteins with homology to murine Wnt-2, -4 and -5A/B. The expression patterns of the latter two zebrafish genes, designated ZfWnt4 and ZfWnt5 show considerable similarity with their homologues in other vertebrates; ZfWnt2, however, is expressed in the developing viscera in a pattern distinct from its closest murine homologue. In the light of the similarities and differences in the patterns of expression of these genes relative to their homologues in other vertebrates, we speculate on their possible functions.