ZFIN ID: ZDB-GENE-980526-283
Gene Name: early growth response 2b
Gene Symbol: egr2b
Previous Names: cb427 (1), egr2 (1), krx20, id:ibd5073 (1), krox-20, krox20, wu:fb71h10, zgc:92210
Location: Chr: 12   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 458 figures from 317 publications
Directly Submitted Expression Data: 9 figures (19 images) from Rauch et al., 2003 [fb71h10]
  2 figures (2 images) from Kudoh et al., 2001 [ibd5073]
  6 figures (15 images) from Thisse et al., 2001 [cb427]
Wild-type Stages, Structures: Cleavage:2-cell (0.75h-1.0h) to Larval:Days 7-13 (168.0h-14d, 4.5mm, 8 teeth)
  brain, cranial neural crest, glial cell, hindbrain (all 26) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 9 genotypes
Alleles: egr2b_unrecovered, fh227, sa10063, sa18210
PHENOTYPE
Data: 3 figures from 2 publications
Observed in: hindbrain, hindbrain structural organization, posterior lateral line nerve compact myelin, posterior lateral line nerve myelin sheath

Phenotype of Human Orthologue OMIM Phenotype ID
Charcot-Marie-Tooth disease, type 1D 607678
Dejerine-Sottas disease 145900
Neuropathy, congenital hypomyelinating, 1 605253
GENE ONTOLOGY
Ontology GO Term
Biological Process hindbrain morphogenesis (more)
Cellular Component nucleus (more)
Molecular Function DNA binding (more)
GO Terms (all 16)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR007087 (1)
  • InterPro:IPR013087 (1)
  • InterPro:IPR015880 (1)
  • InterPro:IPR021849 (1)
  • PROSITE:PS00028 (1)
  • PROSITE:PS50157 (1)
  • Pfam:PF11928 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA egr2b-001 (1) 2043
    egr2b-002 (1) 853
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS
    Addgene
    CONSTRUCTS WITH SEQUENCES FROM egr2b
    Tg(egr2b-gata2a:EGFP), Tg(egr2b:EGFP), TgBAC(egr2b:GFP)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    egr2b Contained in: [BAC] DKEY-247F17 (1)
    egr2b Encodes: [EST] cb427 (1) (order this), fb71h10, ibd5073 (1) (order this)
    [cDNA] MGC:92210 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_130997 (1) 2065 bp
    Genomic GenBank:CR354434 (1) 153813 bp
    Select Tool
    Polypeptide UniProtKB:Q05159 (1) 412 aa
    Sequence Clusters UniGene:75080 (1)
    Sequence Information (all 20)
    OTHER egr2b GENE PAGES
  • Gene:30190 (1)
  • VEGA:OTTDARG00000027335 (1)
  • Ensembl(Zv9):ENSDARG00000042826 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish egr2b 12  
    Fruit fly sr 3R
  • FLYBASE:FBgn0003499
  • Gene:42162
  • Human EGR2 10 (10q21.1)
  • OMIM:129010
  • Gene:1959
  • Mouse Egr2 10 ( 34.96 cM)
  • MGI:95296
  • Gene:13654
  • Orthology Details
    CITATIONS (606)