ZFIN ID: ZDB-GENE-980526-283
Gene Name: early growth response 2b
Gene Symbol: egr2b
Previous Names: egr2 (1), cb427 (1), id:ibd5073 (1), krox-20, krox20, krx20, wu:fb71h10, zgc:92210
Location: Chr: 12 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 489 figures from 345 publications
Directly Submitted Expression Data: 9 figures (19 images) from Rauch et al., 2003 [fb71h10]
  2 figures (2 images) from Kudoh et al., 2001 [ibd5073]
  6 figures (15 images) from Thisse et al., 2001 [cb427]
Wild-type Stages, Structures: Cleavage:2-cell (0.75h-1.0h) to Larval:Days 7-13 (168.0h-14d, 4.5mm, 8 teeth)
  brain, central nervous system, cranial neural crest, ectoderm (all 42) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
egr2b_unrecovered Point Mutation Unknown Unknown ENU
fh227 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa10063 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa18210 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE
    Data: 4 figures from 3 publications
    Observed in: hindbrain, hindbrain structural organization, posterior lateral line nerve compact myelin, posterior lateral line nerve myelin sheath (all 7) expand
    DISEASE ASSOCIATED WITH egr2b HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    Charcot-Marie-Tooth disease type 1D Charcot-Marie-Tooth disease, type 1D 607678
    Charcot-Marie-Tooth disease type 3 Dejerine-Sottas disease 145900
    Charcot-Marie-Tooth disease type 4 Dejerine-Sottas disease 145900
    Charcot-Marie-Tooth disease type 4E Neuropathy, congenital hypomyelinating, 1 605253
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process embryonic organ development (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR007087 (1)
  • InterPro:IPR013087 (1)
  • InterPro:IPR015880 (1)
  • InterPro:IPR021849 (1)
  • PROSITE:PS00028 (1)
  • PROSITE:PS50157 (1)
  • Pfam:PF00096 (1)
  • Pfam:PF11928 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA egr2b-001 (1) 2043
    egr2b-002 (1) 853
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYSNo data available
    ANTIBODIESNo data available
    PLASMIDS
    Addgene
    CONSTRUCTS WITH SEQUENCES FROM egr2b
    Tg(egr2b-gata2a:EGFP), Tg(egr2b:EGFP), TgBAC(egr2b:GFP)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    egr2bContained in: [BAC] DKEY-247F17 (1) (order this)
    egr2bEncodes: [EST] cb427 (1) (order this), fb71h10 (order this), ibd5073 (1) (order this)
    [cDNA] MGC:92210 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_130997 (1) 2065bp
    Genomic GenBank:CR354434 (1) 153813bp
    Select Tool
    Polypeptide UniProtKB:Q05159 (1) 412aa
    Sequence Clusters UniGene:75080 (1)
    Sequence Information (all 18)
    OTHER egr2b GENE PAGES
  • Gene:30190 (1)
  • VEGA:OTTDARG00000027335 (1)
  • Ensembl(GRCz10):ENSDARG00000042826 (1)
  • ORTHOLOGY for egr2b (Chr: 12)
    Species Symbol Chromosome Accession # Evidence
    Human EGR2 10
  • Gene:1959
  • OMIM:129010
  • HGNC:3239
  • Amino acid sequence comparison (2)
    Conserved genome location (synteny) (2)
    Mouse Egr2 10
  • MGI:95296
  • Gene:13654
  • Amino acid sequence comparison (1)
    Conserved genome location (synteny) (1)
    Fruit fly sr 3R
  • FLYBASE:FBgn0003499
  • Gene:42162
  • Conserved genome location (synteny) (1)
    Download Curated Orthology
    CITATIONS (657)