ZFIN Gene: egr2b

ZFIN ID: ZDB-GENE-980526-283

ZFIN ID: ZDB-GENE-980526-283

Gene Name:	early growth response 2b
Gene Symbol:	egr2b
Previous Names:	cb427 (1), egr2 (1), krx20, id:ibd5073 (1), krox-20, krox20, wu:fb71h10, zgc:92210
Nomenclature History

GENE EXPRESSION
All Expression Data:	404 figures from 280 publications
Directly Submitted Expression Data:	9 figures (19 images) from Rauch et al., 2003 [fb71h10]
	2 figures (2 images) from Kudoh et al., 2001 [ibd5073]
	6 figures (15 images) from Thisse et al., 2001 [cb427]
Wild-type Stages, Structures:	Cleavage:2-cell (0.75h-1.0h) to Larval:Days 7-13 (168.0h-14d, 4.5mm, 8 teeth)
	brain , cranial neural crest , glial cell , hindbrain (all 23)
Curated Microarray Expression:	GEO (1)

MUTANTS AND TARGETED KNOCKDOWNS

Mutant lines:	6 genotypes
Alleles:	egr2b_unrecovered, fh227, sa10063

PHENOTYPE

Data:	2 figures from Monk et al., 2009
Observed in:	posterior lateral line nerve compact myelin, posterior lateral line nerve myelin sheath

Phenotype of Human Orthologue	OMIM Phenotype ID
Charcot-Marie-Tooth disease, type 1D	607678
Dejerine-Sottas disease	145900
Neuropathy, congenital hypomyelinating, 1	605253

GENE ONTOLOGY

Ontology	GO Term
Biological Process	myelination of posterior lateral line nerve axons (more)
Cellular Component	nucleus (more)
Molecular Function	DNA binding (more)

GO Terms (all 9)

PROTEIN FAMILIES, DOMAINS AND SITES
InterPro:IPR007087 (1) InterPro:IPR013087 (1) InterPro:IPR015880 (1) InterPro:IPR021849 (1)	PROSITE:PS00028 (1) PROSITE:PS50157 (1)	Pfam:PF11928 (1)

TRANSCRIPTS
Type	Name	Length (bp)	Analysis
mRNA	egr2b-001 (1)	2043	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT Vega
	egr2b-002 (1)	853	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT Vega

GENE PRODUCT DESCRIPTION

ANTIBODIES No data available

CONSTRUCTS WITH SEQUENCES FROM egr2b

Tg(egr2b-gata2a:EGFP), Tg(egr2b:EGFP), TgBAC(egr2b:GFP)

SEGMENT (CLONE AND PROBE) RELATIONSHIPS

egr2b Contained in:	[BAC] DKEY-247F17 (1) (order this)
egr2b Encodes:	[EST] cb427 (1) (order this), fb71h10 (order this), ibd5073 (1) (order this) [cDNA] MGC:92210 (1) (order this)

SEQUENCE INFORMATION

Type	Accession #	Length (bp/aa)	Analysis
RNA	RefSeq:NM_130997 (1)	2065 bp	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT Vega
Genomic	GenBank:CR354434 (1)	153813 bp	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:Q66HY5 (1)	412 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast Vega Protein Blast
Sequence Clusters	UniGene:75080 (1)

OTHER egr2b GENE PAGES

Gene:30190 (1)

VEGA:OTTDARG00000027335 (1)

Ensembl(Zv9):ENSDARG00000042826 (1)

MAPPING INFORMATION
Chr: 12 Details	View Map: Merged Individual Panels

ORTHOLOGY

CITATIONS (546)