Gene

gata1a

ID

ZDB-GENE-980526-268

Name

GATA binding protein 1a

Symbol

gata1a Nomenclature History

Previous Names

gata1
gta1 (1)
zg1
etID309774.11 (1)
sb:eu551
vlad tepes
vlt

Type

protein_coding_gene

Location

Chr: 11 Mapping Details/Browsers

Description

Enables DNA-binding transcription factor activity; double-stranded DNA binding activity; and sequence-specific DNA binding activity. Acts upstream of or within several processes, including hemopoiesis; regulation of gene expression; and regulation of primitive erythrocyte differentiation. Predicted to be located in nucleus. Is expressed in several structures, including ball; cardiovascular system; hematopoietic cell; hematopoietic system; and mesoderm. Human ortholog(s) of this gene implicated in several diseases, including Down syndrome; X-linked recessive disease (multiple); bone marrow cancer (multiple); colon adenocarcinoma; and myeloid leukemia associated with Down Syndrome. Orthologous to human GATA1 (GATA binding protein 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

496 figures from 348 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu551 (10 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 26 figures from 19 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With gata1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
congenital nonspherocytic hemolytic anemia 9	Alliance	Anemia, congenital, nonspherocytic hemolytic, 9	301083
thrombocytopenia	Alliance	Thrombocytopenia, X-linked, with or without dyserythropoietic anemia	300367
transient myeloproliferative syndrome	Alliance	Leukemia, megakaryoblastic, with or without Down syndrome, somatic	159595
X-linked dyserythropoietic anemia	Alliance	Anemia, X-linked, with/without neutropenia and/or platelet abnormalities	300835
X-linked thrombocytopenia with beta-thalassemia	Alliance	Thrombocytopenia with beta-thalassemia, X-linked	314050

Associated With gata1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000679	Zinc finger, GATA-type
Family	IPR016374	Transcription factor, GATA-2/3
Family	IPR039355	Transcription factor GATA
Homologous_superfamily	IPR013088	Zinc finger, NHR/GATA-type