Gene
gata1a
- ID
- ZDB-GENE-980526-268
- Name
- GATA binding protein 1a
- Symbol
- gata1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Exhibits DNA-binding transcription factor activity; double-stranded DNA binding activity; and sequence-specific DNA binding activity. Involved in several processes, including hemopoiesis; regulation of gene expression; and regulation of myeloid cell differentiation. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in Down syndrome; X-linked thrombocytopenia with beta-thalassemia; beta thalassemia; and bone marrow cancer (multiple). Is expressed in several structures, including ball; hematopoietic cell; hematopoietic system; mesoderm; and vasculature. Orthologous to human GATA1 (GATA binding protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 494 figures from 346 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu551 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- 26 figures from 19 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| thrombocytopenia | Alliance | Thrombocytopenia, X-linked, with or without dyserythropoietic anemia | 300367 |
| transient myeloproliferative syndrome | Alliance | Leukemia, megakaryoblastic, with or without Down syndrome, somatic | 159595 |
| X-linked dyserythropoietic anemia | Alliance | Anemia, X-linked, with/without neutropenia and/or platelet abnormalities | 300835 |
| X-linked thrombocytopenia with beta-thalassemia | Alliance | Thrombocytopenia with beta-thalassemia, X-linked | 314050 |
| Anemia, congenital, nonspherocytic hemolytic, 9 | 301083 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Transcription factor GATA | Transcription factor, GATA-2/3 | Zinc finger, GATA-type | Zinc finger, NHR/GATA-type |
|---|---|---|---|---|---|
|
UniProtKB:A0A2R8QT05
|
418 | ||||
|
UniProtKB:Q90410
|
418 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
gata1a-201
(1)
|
Ensembl | 1,657 nt | ||
| ncRNA |
gata1a-002
(1)
|
Ensembl | 730 nt |
Interactions and Pathways
Plasmids
No data available