ZFIN ID: ZDB-GENE-980526-112
Gene Name: ISL LIM homeobox 1
Gene Symbol: isl1
Previous Names: Isl-1 (1), islet-1
Location: Chr: 5   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 231 figures from 160 publications
Directly Submitted Expression Data: 6 figures (12 images) from Thisse et al., 2005 [eu243]
  6 figures (12 images) from Thisse et al., 2004 [MGC:73031]
Wild-type Stages, Structures: Gastrula:Bud (10.0h-10.33h) to Adult (90d-730d, breeding adult)
  anterior commissure, anterior lateral plate mesoderm, brain, CaP motoneuron (all 102) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 8 genotypes
Alleles: rw436, sa29
Knockdown reagents: MO1-isl1 (1), MO2-isl1 (1), MO3-isl1 (1), MO4-isl1 (1), MO5-isl1 (1) (all 6) expand
PHENOTYPE
Data: 17 figures from 7 publications
Observed in: atrial cardiac muscle cell differentiation, atrium cardiac muscle cell, blood, CaP motoneuron axon (all 27) expand
GENE ONTOLOGY
Ontology GO Term
Biological Process exocrine pancreas development (more)
Cellular Component nucleus (more)
Molecular Function DNA binding (more)
GO Terms (all 21)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001356 (1)
  • InterPro:IPR001781 (1)
  • InterPro:IPR009057 (1)
  • InterPro:IPR017970 (1)
  • PROSITE:PS00027 (1)
  • PROSITE:PS00478 (1)
  • PROSITE:PS50023 (1)
  • PROSITE:PS50071 (1)
  • Pfam:PF00046 (1)
  • Pfam:PF00412 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA isl1-001 (1) 2303
    GENE PRODUCT DESCRIPTION
    ANTIBODIES
    Ab1-isl (1), Ab1-isl1 (1), Ab2-isl (1)
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM isl1
    Tg(2xNRSE-isl1-Mmu.Fos:KalTA4,5xUAS-E1b:GAP-YFP-2A-NTR), Tg(Hsa.ISL1-isl1:GFP), Tg(hsp70l:isl1), Tg(isl1-hsp70l:dnplxna4-GFP), Tg(isl1-hsp70l:GFP) (all 20) expand
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    isl1 Contained in: [BAC] CH211-219F7 (1) (order this)
    isl1 Contains: [SNP] rs3727897 (1)
    isl1 Encodes: [EST] eu243 (1)
    [cDNA] MGC:73031 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_130962 (1) 2275 bp
    Genomic GenBank:AL954694 (1) 111431 bp
    Select Tool
    Polypeptide UniProtKB:P53405 (1) 349 aa
    Sequence Clusters UniGene:75106 (1)
    Sequence Information (all 18)
    OTHER isl1 GENE PAGES
  • Gene:30147 (1)
  • VEGA:OTTDARG00000018571 (1)
  • Ensembl(Zv9):ENSDARG00000004023 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA NT CL
    Zebrafish isl1 5  
    Human ISL1 5 (5q11.1)
  • OMIM:600366
  • Gene:3670
  • Mouse Isl1 13 ( 64.87 cM)
  • MGI:101791
  • Gene:16392
  • Orthology Details
    CITATIONS (314)