ZFIN ID: ZDB-GENE-980526-112
Gene Name: ISL LIM homeobox 1
Gene Symbol: isl1
Previous Names: Isl-1 (1), islet-1
Location: Chr: 5 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 249 figures from 176 publications
Directly Submitted Expression Data: 6 figures (12 images) from Thisse et al., 2005 [eu243]
  6 figures (12 images) from Thisse et al., 2004 [MGC:73031]
Wild-type Stages, Structures: Gastrula:Bud (10.0h-10.33h) to Adult (90d-730d, breeding adult)
  amacrine cell, anterior commissure, anterior lateral plate mesoderm, brain (all 121) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS 
Allele Type Mutagen Suppliers
rw436 Point Mutation ENU
sa29 Point Mutation ENU
Targeting reagents: MO1-isl1 (1), MO2-isl1 (1), MO3-isl1 (1), MO4-isl1 (1), MO5-isl1 (1) (all 6) expand
PHENOTYPE
Data: 26 figures from 10 publications
Observed in: atrial cardiac muscle cell differentiation, atrium cardiac muscle cell, blood, CaP motoneuron axon (all 38) expand
DISEASE ASSOCIATED WITH isl1 HUMAN ORTHOLOG No data available
GENE ONTOLOGY 
Ontology GO Term
Biological Process exocrine pancreas development (more)
Cellular Component nucleus (more)
Molecular Function DNA binding (more)
GO Terms (all 22)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001356 (1)
  • InterPro:IPR001781 (1)
  • InterPro:IPR009057 (1)
  • InterPro:IPR017970 (1)
  • PROSITE:PS00027 (1)
  • PROSITE:PS00478 (1)
  • PROSITE:PS50023 (1)
  • PROSITE:PS50071 (1)
  • Pfam:PF00046 (1)
  • Pfam:PF00412 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA isl1-001 (1) 2303
    GENE PRODUCT DESCRIPTION
    ANTIBODIES 
    Ab1-isl (1), Ab1-isl1 (1), Ab2-isl (1)
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM isl1
    Tg(2XNRSE-isl1-Mmu.Fos:KALTA4,5xUAS-ADV.E1b:GAP-YFP-2A-NTR_T41Q_N71S_F124T), Tg(2xNRSE-isl1-Mmu.Fos:KALTA4,5xUAS-E1b:GAP-YFP-2A-NTR), Tg(Hsa.ISL1-isl1:GFP), Tg(hsp70l:isl1), Tg(isl1-hsp70l:dnplxna4-GFP) (all 25) expand
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS 
    isl1Contained in: [BAC] CH211-219F7 (1) (order this)
    isl1Contains: [SNP] rs3727897 (1)
    isl1Encodes: [EST] eu243 (1)
    [cDNA] MGC:73031 (1) (order this)
    SEQUENCE INFORMATION 
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_130962 (1) 2275bp
    Genomic GenBank:AL954694 (1) 111431bp
    Select Tool
    Polypeptide UniProtKB:P53405 (1) 349aa
    Sequence Clusters UniGene:75106 (1)
    Sequence Information (all 18)
    OTHER isl1 GENE PAGES 
  • Gene:30147 (1)
  • VEGA:OTTDARG00000018571 (1)
  • Ensembl(GRCz10):ENSDARG00000004023 (1)
  • ORTHOLOGY for isl1 (Chr: 5) 
    Species Symbol Chromosome Accession # Evidence
    Human ISL1 5
  • Gene:3670
  • OMIM:600366
  • HGNC:6132
  • Amino acid sequence comparison (2)
    Conserved genome location (synteny) (2)
    Nucleotide sequence comparison (1)
    Mouse Isl1 13
  • MGI:101791
  • Gene:16392
  • Amino acid sequence comparison (1)
    Conserved genome location (synteny) (1)
    Nucleotide sequence comparison (1)
    Download Curated Orthology
    CITATIONS (337)