ZFIN ID: ZDB-GENE-980526-112
Gene Name: ISL LIM homeobox 1
Gene Symbol: isl1
Previous Names: Isl-1 (1), islet-1
Location: Chr: 5 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 251 figures from 177 publications
Directly Submitted Expression Data: 6 figures (12 images) from Thisse et al., 2005 [eu243]
  6 figures (12 images) from Thisse et al., 2004 [MGC:73031]
Wild-type Stages, Structures: Gastrula:Bud (10.0h-10.33h) to Adult (90d-730d, breeding adult)
  amacrine cell, anterior commissure, anterior lateral plate mesoderm, brain (all 121) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
rw436 Point Mutation Unknown Cryptic Acceptor Splice Site, Frameshift, Premature Stop ENU
sa29 Point Mutation Unknown Unknown ENU
Targeting reagents: MO1-isl1 (1), MO2-isl1 (1), MO3-isl1 (1), MO4-isl1 (1), MO5-isl1 (1) (all 6) expand
PHENOTYPE
Data: 26 figures from 10 publications
Observed in: atrial cardiac muscle cell differentiation, atrium cardiac muscle cell, blood, CaP motoneuron axon (all 38) expand
DISEASE ASSOCIATED WITH isl1 HUMAN ORTHOLOGNo data available
GENE ONTOLOGY
Ontology GO Term
Biological Process exocrine pancreas development (more)
Cellular Component nucleus (more)
Molecular Function DNA binding (more)
GO Terms (all 22)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001356 (1)
  • InterPro:IPR001781 (1)
  • InterPro:IPR009057 (1)
  • InterPro:IPR017970 (1)
  • PROSITE:PS00027 (1)
  • PROSITE:PS00478 (1)
  • PROSITE:PS50023 (1)
  • PROSITE:PS50071 (1)
  • Pfam:PF00046 (1)
  • Pfam:PF00412 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA isl1-001 (1) 2303
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYSNo data available
    ANTIBODIES
    Ab1-isl (1), Ab1-isl1 (1), Ab2-isl (1)
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM isl1
    Tg(2XNRSE-isl1-Mmu.Fos:KALTA4,5xUAS-ADV.E1b:GAP-YFP-2A-NTR_T41Q_N71S_F124T), Tg(2xNRSE-isl1-Mmu.Fos:KALTA4,5xUAS-E1b:GAP-YFP-2A-NTR), Tg(Hsa.ISL1-isl1:GFP), Tg(hsp70l:isl1), Tg(isl1-hsp70l:dnplxna4-GFP) (all 25) expand
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    isl1Contained in: [BAC] CH211-219F7 (1) (order this)
    isl1Contains: [SNP] rs3727897 (1)
    isl1Encodes: [EST] eu243 (1)
    [cDNA] MGC:73031 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_130962 (1) 2275bp
    Genomic GenBank:AL954694 (1) 111431bp
    Select Tool
    Polypeptide UniProtKB:P53405 (1) 349aa
    Sequence Clusters UniGene:75106 (1)
    Sequence Information (all 18)
    OTHER isl1 GENE PAGES
  • Gene:30147 (1)
  • VEGA:OTTDARG00000018571 (1)
  • Ensembl(GRCz10):ENSDARG00000004023 (1)
  • ORTHOLOGY for isl1 (Chr: 5)
    Species Symbol Chromosome Accession # Evidence
    Human ISL1 5
  • Gene:3670
  • OMIM:600366
  • HGNC:6132
  • Amino acid sequence comparison (2)
    Conserved genome location (synteny) (2)
    Nucleotide sequence comparison (1)
    Mouse Isl1 13
  • MGI:101791
  • Gene:16392
  • Amino acid sequence comparison (1)
    Conserved genome location (synteny) (1)
    Nucleotide sequence comparison (1)
    Download Curated Orthology
    CITATIONS (340)