ZFIN ID: ZDB-GENE-980526-562
Gene Name: ISL LIM homeobox 2a
Gene Symbol: isl2a
Sequence Ontology ID : SO:0000704

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: isl2, zfIsl-2, wu:fc29g02

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Location: Chr: 25 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 81 figures from 55 publications
Directly Submitted Expression Data: 6 figures (17 images) from Thisse et al., 2005 [eu308]
Wild-type Stages, Structures: Segmentation:1-4 somites (10.33h-11.66h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
  basal plate midbrain region, brain, CaP motoneuron, cloaca (all 37) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ca20 Insertion Unknown Frameshift, Premature Stop TALEN
ca21 Small Deletion Unknown Frameshift, Premature Stop TALEN
sa24713 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24714 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Targeting reagents: MO1-isl2a (1), MO2-isl2a (1), MO3-isl2a (1), MO4-isl2a (1), MO5-isl2a (1) (all 6) expand
    PHENOTYPE
    Data: 6 figures from 3 publications
    Observed in: anatomical structure, angioblast cell migration, CaP motoneuron axon, CaP motoneuron axon extension (all 9) expand
    DISEASE ASSOCIATED WITH isl2a HUMAN ORTHOLOGNo data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process axonogenesis (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001356 (1)
  • InterPro:IPR001781 (1)
  • InterPro:IPR009057 (1)
  • InterPro:IPR017970 (1)
  • PROSITE:PS00027 (1)
  • PROSITE:PS00478 (1)
  • PROSITE:PS50023 (1)
  • PROSITE:PS50071 (1)
  • Pfam:PF00046 (1)
  • Pfam:PF00412 (1)
  • TRANSCRIPTS No data available
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Ab1-isl (1), Ab2-isl (1)
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM isl2a
    Tg(hsp70l:isl2a), Tg1(FRT-Xla.Actc1:DsRed-GAB-FRT,LOXP-isl2a-LOXP-gata2a:EGFP-5HS4), Tg2(FRT-Xla.Actc1:DsRed-GAB-FRT,LOXP-isl2a-LOXP-gata2a:EGFP-5HS4), Tg3(FRT-Xla.Actc1:DsRed-GAB-FRT,LOXP-isl2a-LOXP-gata2a:EGFP-5HS4)
    MARKER RELATIONSHIPS
    isl2aEncodes: [EST] eu308 (1), fc29g02
    [cDNA] MGC:193978 (1) (order this), MGC:193993 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_130970 (1) 1713bp
    Genomic GenBank:CABZ01056691 (1) 12610bp
    Polypeptide UniProtKB:B3DH43 (1) 359aa
    Sequence Clusters UniGene:281 (1)
    Sequence Information (all 32)
    OTHER isl2a GENE PAGES
  • Alliance (1)
  • Gene:30157 (1)
  • Ensembl(GRCz10):ENSDARG00000003971 (1)
  • ORTHOLOGY for isl2a (Chr: 25)
    CITATIONS (100)