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ZIRC
ZFIN ID: ZDB-GENE-980526-562
Gene Name: ISL LIM homeobox 2a
Gene Symbol: isl2a    Nomenclature History

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Previous Names: isl2, zfIsl-2, wu:fc29g02

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 25 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in blood vessel morphogenesis; exocrine pancreas development; and neuron differentiation. Predicted to localize to the nucleus. Is expressed in several structures, including ectoderm; gut; liver and biliary system; nervous system; and neural tube. Orthologous to human ISL2 (ISL LIM homeobox 2).
Genome Resources: Alliance (1),  Gene:30157 (1),  Ensembl(GRCz11):ENSDARG00000003971 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ca20 Insertion Unknown Frameshift, Premature Stop TALEN
ca21 Indel Unknown Frameshift, Premature Stop TALEN
co7002 Small Deletion Exon 2 Frameshift, Premature Stop TALEN
co7003 Small Deletion Unknown Frameshift, Premature Stop TALEN
sa24713 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24714 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • uhm2 Small Deletion Exon 2 Unknown TALEN
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-isl2a N/A 4
    MO2-isl2a N/A 2
    MO3-isl2a N/A 2
    MO4-isl2a N/A 1
    MO5-isl2a N/A 1
    MO6-isl2a N/A 1
    TALEN1-isl2a 1
    TALEN2-isl2a 1
    TALEN3-isl2a 1
    DISEASE ASSOCIATED WITH isl2a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH isl2a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process axonogenesis (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 14)
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-isl monoclonal IgG1 Mouse IHC Developmental Studies Hybridoma Bank
    24
    Ab2-isl monoclonal IgG2b Mouse IHC Developmental Studies Hybridoma Bank
    115
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM isl2a
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(hsp70l:isl2a) hsp70l isl2a Danio rerio 1 5
    Tg1(FRT-Xla.Actc1:DsRed-GAB-FRT,LOXP-isl2a-LOXP-gata2a:EGFP-5HS4) gata2aisl2a 5HS4DsRedEGFPGAB Danio rerioXenopus laevis 3 3
    Tg2(FRT-Xla.Actc1:DsRed-GAB-FRT,LOXP-isl2a-LOXP-gata2a:EGFP-5HS4) gata2aisl2a 5HS4DsRedEGFPGAB Danio rerioXenopus laevis 3 3
    Tg3(FRT-Xla.Actc1:DsRed-GAB-FRT,LOXP-isl2a-LOXP-gata2a:EGFP-5HS4) gata2aisl2a 5HS4DsRedEGFPGAB Danio rerioXenopus laevis 3 3
    MARKER RELATIONSHIPS
    isl2a Encodes: [EST] eu308 (1), fc29g02
    [cDNA] MGC:193978 (1) (order this), MGC:193993 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_130970 (1) 1713 bp
    Genomic GenBank:CABZ01056691 (1) 12610 bp
    Polypeptide UniProtKB:B3DH43 (1) 359 aa
    Sequence Clusters UniGene:281 (1)
    Sequence Information (all 32)
    ORTHOLOGY for isl2a ( Chr: 25 )
    CITATIONS (109)