Gene
nek10
- ID
- ZDB-GENE-130530-570
- Name
- NIMA-related kinase 10
- Symbol
- nek10 Nomenclature History
- Previous Names
-
- si:ch211-231m23.2
- zmp:0000000567 (1)
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to have protein serine/threonine kinase activity. Predicted to be involved in positive regulation of MAP kinase activity and regulation of cell cycle G2/M phase transition. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia. Is expressed in female organism. Orthologous to human NEK10 (NIMA related kinase 10).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Newman et al., 2019
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| primary ciliary dyskinesia 44 | Alliance | Ciliary dyskinesia, primary, 44 | 618781 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Family | IPR050660 | NEK Serine/Threonine Protein Kinase |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR011989 | Armadillo-like helical |
| Homologous_superfamily | IPR016024 | Armadillo-type fold |
| Repeat | IPR000225 | Armadillo |
Domain Details Per Protein
| Protein | Length | Armadillo | Armadillo-like helical | Armadillo-type fold | NEK Serine/Threonine Protein Kinase | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Tyrosine-protein kinase, active site |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M3ATV8
|
998 | ||||||||
|
UniProtKB:A0A8M3AJH8
|
1027 |
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance