Gene
pam
- ID
- ZDB-GENE-090313-384
- Name
- peptidylglycine alpha-amidating monooxygenase
- Symbol
- pam Nomenclature History
- Previous Names
-
- si:dkeyp-35f12.2 (1)
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Exhibits peptidylglycine monooxygenase activity. Involved in ciliary basal body-plasma membrane docking and microvillus assembly. Predicted to localize to extracellular region. Is expressed in floor plate; gut; otic vesicle; and ventricular system. Orthologous to human PAM (peptidylglycine alpha-amidating monooxygenase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Kumar et al., 2018
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 7 figures from Kumar et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000323 | Copper type II, ascorbate-dependent monooxygenase, N-terminal |
| Domain | IPR024548 | Copper type II ascorbate-dependent monooxygenase, C-terminal |
| Family | IPR000720 | Peptidylglycine alpha-hydroxylating monooxygenase/peptidyl-hydroxyglycine alpha-amidating lyase |
| Homologous_superfamily | IPR008977 | PHM/PNGase F domain superfamily |
| Homologous_superfamily | IPR011042 | Six-bladed beta-propeller, TolB-like |
| Homologous_superfamily | IPR014784 | Copper type II, ascorbate-dependent monooxygenase-like, C-terminal |
| Homologous_superfamily | IPR036939 | Copper type II, ascorbate-dependent monooxygenase, N-terminal domain superfamily |
| Repeat | IPR001258 | NHL repeat |
Domain Details Per Protein
| Protein | Length | Copper type II ascorbate-dependent monooxygenase, C-terminal | Copper type II, ascorbate-dependent monooxygenase-like, C-terminal | Copper type II, ascorbate-dependent monooxygenase, N-terminal | Copper type II, ascorbate-dependent monooxygenase, N-terminal domain superfamily | NHL repeat | Peptidylglycine alpha-hydroxylating monooxygenase/peptidyl-hydroxyglycine alpha-amidating lyase | PHM/PNGase F domain superfamily | Six-bladed beta-propeller, TolB-like |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M6Z0R0
|
779 | ||||||||
|
UniProtKB:A0A8M2B2D2
|
1010 | ||||||||
|
UniProtKB:A0A8M3B606
|
909 |
Interactions and Pathways
No data available
Plasmids
No data available