Gene

chrna6

ID
ZDB-GENE-090312-91
Name
cholinergic receptor, nicotinic, alpha 6
Symbol
chrna6 Nomenclature History
Previous Names
  • si:dkey-234d14.1
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Predicted to enable acetylcholine-gated monoatomic cation-selective channel activity. Predicted to contribute to acetylcholine receptor activity. Predicted to be involved in several processes, including presynaptic modulation of chemical synaptic transmission; response to nicotine; and synaptic signaling. Predicted to act upstream of or within monoatomic ion transport. Predicted to be located in postsynaptic membrane. Predicted to be part of acetylcholine-gated channel complex. Predicted to be active in neuron projection; plasma membrane; and synapse. Is expressed in immature eye and nervous system. Human ortholog(s) of this gene implicated in alcohol use disorder; cocaine abuse; and nicotine dependence. Orthologous to human CHRNA6 (cholinergic receptor nicotinic alpha 6 subunit).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
5 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
sa15480Allele with one point mutationUnknownSplice SiteENU
zko426aAllele with one deletionUnknownUnknownCRISPR
zko426bAllele with one deletionUnknownUnknownCRISPR
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
CRISPR1-chrna6 (2)
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Human Disease
Associated With chrna6 Human Ortholog
No data available
Associated With chrna6 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018000 Neurotransmitter-gated ion-channel, conserved site
Domain IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
Domain IPR006202 Neurotransmitter-gated ion-channel ligand-binding domain
Family IPR002394 Nicotinic acetylcholine receptor
Family IPR006201 Neurotransmitter-gated ion-channel
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Domain Details Per Protein
Protein Additional Resources Length Neuronal acetylcholine receptor Neurotransmitter-gated ion-channel Neurotransmitter-gated ion-channel, conserved site Neurotransmitter-gated ion-channel ligand-binding domain Neurotransmitter-gated ion-channel ligand-binding domain superfamily Neurotransmitter-gated ion-channel transmembrane domain Neurotransmitter-gated ion-channel transmembrane domain superfamily Nicotinic acetylcholine receptor
UniProtKB:Q0PJT9 InterPro 512
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 1
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA chrna6-201 (1) Ensembl 1,937 nt
mRNA chrna6-202 (1) Ensembl 4,807 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-240P12ZFIN Curated Data
Contained inBACDKEY-234D14ZFIN Curated Data
EncodescDNAMGC:198130ZFIN Curated Data
EncodescDNAMGC:198132ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanCHRNA68
Conserved genome location (synteny) (2)
Amino acid sequence comparison (2)
Phylogenetic tree (1)
MouseChrna68
Phylogenetic tree (1)
Amino acid sequence comparison (1)
Citations
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