Gene
chrna6
- ID
- ZDB-GENE-090312-91
- Name
- cholinergic receptor, nicotinic, alpha 6
- Symbol
- chrna6 Nomenclature History
- Previous Names
-
- si:dkey-234d14.1
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable acetylcholine-gated monoatomic cation-selective channel activity. Predicted to contribute to acetylcholine receptor activity. Predicted to be involved in several processes, including presynaptic modulation of chemical synaptic transmission; response to nicotine; and synaptic signaling. Predicted to act upstream of or within monoatomic ion transport. Predicted to be located in postsynaptic membrane. Predicted to be part of acetylcholine-gated channel complex. Predicted to be active in neuron projection; plasma membrane; and synapse. Is expressed in immature eye and nervous system. Human ortholog(s) of this gene implicated in alcohol use disorder; cocaine abuse; and nicotine dependence. Orthologous to human CHRNA6 (cholinergic receptor nicotinic alpha 6 subunit).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR018000 | Neurotransmitter-gated ion-channel, conserved site |
Domain | IPR006029 | Neurotransmitter-gated ion-channel transmembrane domain |
Domain | IPR006202 | Neurotransmitter-gated ion-channel ligand-binding domain |
Family | IPR002394 | Nicotinic acetylcholine receptor |
Family | IPR006201 | Neurotransmitter-gated ion-channel |
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Domain Details Per Protein
Protein | Additional Resources | Length | Neuronal acetylcholine receptor | Neurotransmitter-gated ion-channel | Neurotransmitter-gated ion-channel, conserved site | Neurotransmitter-gated ion-channel ligand-binding domain | Neurotransmitter-gated ion-channel ligand-binding domain superfamily | Neurotransmitter-gated ion-channel transmembrane domain | Neurotransmitter-gated ion-channel transmembrane domain superfamily | Nicotinic acetylcholine receptor |
---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:Q0PJT9 | InterPro | 512 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
chrna6-201
(1)
|
Ensembl | 1,937 nt | ||
mRNA |
chrna6-202
(1)
|
Ensembl | 4,807 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-240P12 | ZFIN Curated Data | |
Contained in | BAC | DKEY-234D14 | ZFIN Curated Data | |
Encodes | cDNA | MGC:198130 | ZFIN Curated Data | |
Encodes | cDNA | MGC:198132 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001042684 (1) | 1937 nt | ||
Genomic | GenBank:AL928917 (1) | 176961 nt | ||
Polypeptide | UniProtKB:Q0PJT9 (1) | 512 aa |
- Faillace, M.P., Ortiz, J., Rocco, L., Bernabeu, R. (2024) Histone Methyltransferase G9a Plays an Essential Role on Nicotine Preference in Zebrafish. Molecular neurobiology. 61(9):6245-6263
- Wu, L., Zhao, M., Chen, X., Wang, H. (2024) A miR-219-5p-bmal1b negative feedback loop contributes to circadian regulation in zebrafish. Communications biology. 7:16711671
- Pan, W., Godoy, R.S., Cook, D.P., Scott, A.L., Nurse, C.A., Jonz, M.G. (2022) Single-cell transcriptomic analysis of neuroepithelial cells and other cell types of the gills of zebrafish (Danio rerio) exposed to hypoxia. Scientific Reports. 12:10144
- Ponzoni, L., Melzi, G., Marabini, L., Martini, A., Petrillo, G., Teh, M.T., Torres-Perez, J.V., Morara, S., Gotti, C., Braida, D., Brennan, C.H., Sala, M. (2021) Conservation of mechanisms regulating emotional-like responses on spontaneous nicotine withdrawal in zebrafish and mammals. Progress in neuro-psychopharmacology & biological psychiatry. 111:110334
- García-González, J., Brock, A.J., Parker, M.O., Riley, R.J., Joliffe, D., Sudwarts, A., Teh, M.T., Busch-Nentwich, E.M., Stemple, D.L., Martineau, A.R., Kaprio, J., Palviainen, T., Kuan, V., Walton, R.T., Brennan, C.H. (2020) Identification of slit3 as a locus affecting nicotine preference in zebrafish and human smoking behaviour. eLIFE. 9:
- Pedersen, J.E., Bergqvist, C.A., Larhammar, D. (2019) Evolution of vertebrate nicotinic acetylcholine receptors. BMC Evolutionary Biology. 19:38
- Pisera-Fuster, A., Faillace, M.P., Bernabeu, R. (2019) Pre-Exposure to Nicotine with Nocturnal Abstinence Induces Epigenetic Changes that Potentiate Nicotine Preference. Molecular neurobiology. 57(4):1828-1846
- Pisera-Fuster, A., Rocco, L., Faillace, M.P., Bernabeu, R. (2019) Sensitization-dependent nicotine place preference in the adult zebrafish. Progress in neuro-psychopharmacology & biological psychiatry. 92:457-469
- Sun, Y., Zhang, B., Luo, L., Shi, D.L., Wang, H., Cui, Z., Huang, H., Cao, Y., Shu, X., Zhang, W., Zhou, J., Li, Y., Du, J., Zhao, Q., Chen, J., Zhong, H., Zhong, T.P., Li, L., Xiong, J.W., Peng, J., Xiao, W., Zhang, J., Yao, J., Yin, Z., Mo, X., Peng, G., Zhu, J., Chen, Y., Zhou, Y., Liu, D., Pan, W., Zhang, Y., Ruan, H., Liu, F., Zhu, Z., Meng, A., ZAKOC Consortium (2019) Systematic genome editing of the genes on zebrafish Chromosome 1 by CRISPR/Cas9. Genome research. 30(1):118-26
- Parker, M.O., Evans, A.M., Brock, A.J., Combe, F.J., Teh, M.T., Brennan, C.H. (2016) Moderate alcohol exposure during early brain development increases stimulus-response habits in adulthood. Addiction biology. 21(1):49-60
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