Gene

arhgef25b

ID

ZDB-GENE-080225-17

Name

Rho guanine nucleotide exchange factor (GEF) 25b

Symbol

arhgef25b Nomenclature History

Previous Names

im:7156160

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in axon guidance. Predicted to act upstream of or within regulation of Rho protein signal transduction. Predicted to be active in cytoplasm and plasma membrane. Predicted to be extrinsic component of membrane. Is expressed in ball; epidermis; extension; median fin fold; and periderm. Orthologous to human ARHGEF25 (Rho guanine nucleotide exchange factor 25).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

7 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7156160 (11 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With arhgef25b Human Ortholog

No data available

Associated With arhgef25b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000219	Dbl homology (DH) domain
Domain	IPR001849	Pleckstrin homology domain
Family	IPR051336	Rho GTPase-activating Guanine Nucleotide Exchange Factors
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR035899	Dbl homology (DH) domain superfamily

Domain Details Per Protein

Protein	Length	Dbl homology (DH) domain	Dbl homology (DH) domain superfamily	PH-like domain superfamily	Pleckstrin homology domain	Rho GTPase-activating Guanine Nucleotide Exchange Factors
UniProtKB:A0A2R8Q2V3 InterPro	625
UniProtKB:E7FF78 InterPro	625
UniProtKB:A0A8N7TE15 InterPro	581
UniProtKB:A0A8M9QG91 InterPro	581

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	arhgef25b-201 (1) Ensembl	Ensembl	2,240 nt	Select Tool ZFIN BLAST
mRNA	arhgef25b-202 (1) Ensembl	Ensembl	716 nt	Select Tool ZFIN BLAST
mRNA	arhgef25b-203 (1) Ensembl	Ensembl	1,878 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations