Gene

nkx6.2

ID

ZDB-GENE-070626-1

Name

NK6 homeobox 2

Symbol

nkx6.2 Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Predicted to have DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in pancreatic A cell differentiation; spinal cord motor neuron differentiation; and type B pancreatic cell differentiation. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in spastic ataxia 8. Is expressed in several structures, including central nervous system; endoderm; neural plate; neuroectoderm; and pancreatic system. Orthologous to human NKX6-2 (NK6 homeobox 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

21 figures from 11 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With nkx6.2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
spastic ataxia 8	Alliance	Spastic ataxia 8, autosomal recessive, with hypomyelinating leukodystrophy	617560

Associated With nkx6.2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR000047	Helix-turn-helix motif
Conserved_site	IPR017970	Homeobox, conserved site
Domain	IPR001356	Homeodomain
Domain	IPR020479	Homeodomain, metazoa
Family	IPR050394	Homeobox NK-like transcription regulators
Homologous_superfamily	IPR009057	Homedomain-like superfamily

Domain Details Per Protein

Protein	Length	Helix-turn-helix motif	Homedomain-like superfamily	Homeobox, conserved site	Homeobox NK-like transcription regulators	Homeodomain	Homeodomain, metazoa
UniProtKB:A0A0R4IY89 InterPro	278

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	nkx6.2-201 (1) Ensembl	Ensembl		2,865 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-nkx6	polyclonal	nkx6.1 nkx6.2		Rabbit	IHC		3

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations