Gene
nr0b1
- ID
- ZDB-GENE-070130-1
- Name
- nuclear receptor subfamily 0, group B, member 1
- Symbol
- nr0b1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable transcription corepressor activity. Acts upstream of or within multicellular organismal-level water homeostasis and negative regulation of male gonad development. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; digestive system; fin; interrenal primordium; and reproductive system. Human ortholog(s) of this gene implicated in 46,XY sex reversal 2 and X-linked adrenal hypoplasia congenita. Orthologous to human NR0B1 (nuclear receptor subfamily 0 group B member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 17 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- dq017613 (7 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-nr0b1 | N/A | (2) |
| MO2-nr0b1 | N/A | Powers et al., 2009 |
| MO3-nr0b1 | N/A | Yajima et al., 2012 |
| MO4-nr0b1 | N/A | Yajima et al., 2012 |
| TALEN1-nr0b1 | (2) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| 46,XY sex reversal 2 | Alliance | 46XY sex reversal 2, dosage-sensitive | 300018 |
| X-linked adrenal hypoplasia congenita | Alliance | Adrenal hypoplasia, congenital | 300200 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Nuclear hormone receptor | Nuclear hormone receptor, ligand-binding domain | Nuclear hormone receptor-like domain superfamily | Nuclear receptor subfamily 0 group B member 1/2 |
|---|---|---|---|---|---|
|
UniProtKB:A3KNP5
|
264 |
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Interactions and Pathways
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-218G23 | ZFIN Curated Data | |
| Encodes | EST | dq017613 | Bertrand et al., 2007 | |
| Encodes | cDNA | MGC:162308 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001082947 (1) | 1462 nt | ||
| Genomic | GenBank:CR352256 | 111902 nt | ||
| Polypeptide | UniProtKB:A3KNP5 (1) | 264 aa |
- Vasileva, E., Warren, M., Triche, T.J., Amatruda, J.F. (2022) Dysregulated heparan sulfate proteoglycan metabolism promotes Ewing sarcoma tumor growth. eLIFE. 11:
- Zhang, W., Li, Y., Chen, S., Zhang, C., Chen, L., Peng, G. (2021) nr0b1 (DAX1) loss of function in zebrafish causes hypothalamic defects via abnormal progenitor proliferation and differentiation. Journal of genetics and genomics = Yi chuan xue bao. 49(3):217-229
- King, A.C., Gut, M., Zenker, A.K. (2020) Shedding new light on early sex determination in zebrafish. Archives of toxicology. 94(12):4143-4158
- Chen, W., Liu, L., Ge, W. (2017) Expression analysis of growth differentiation factor 9 (Gdf9/gdf9), anti-müllerian hormone (Amh/amh) and aromatase (Cyp19a1a/cyp19a1a) during gonadal differentiation of the zebrafish, Danio rerio†. Biology of reproduction. 96:401-413
- Ribas, L., Liew, W.C., Díaz, N., Sreenivasan, R., Orbán, L., Piferrer, F. (2017) Heat-induced masculinization in domesticated zebrafish is family-specific and yields a set of different gonadal transcriptomes. Proceedings of the National Academy of Sciences of the United States of America. 114(6):E941-E950
- Yan, Y.L., Desvignes, T., BreMiller, R., Wilson, C., Dillon, D., High, S., Draper, B., Buck, C.L., Postlethwait, J. (2017) The gonadal soma controls ovarian follicle proliferation through Gsdf in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 246(11):925-945
- Chen, S., Zhang, H., Wang, F., Zhang, W., Peng, G. (2016) nr0b1 (DAX1) mutation in zebrafish causes female-to-male sex reversal through abnormal gonadal proliferation and differentiation. Molecular and Cellular Endocrinology. 433:105-16
- Cheng, Y.Y., Tao, W.J., Chen, J.L., Sun, L.N., Zhou, L.Y., Song, Q., Wang, D.S. (2015) Genome-wide identification, evolution and expression analysis of nuclear receptor superfamily in Nile tilapia, Oreochromis niloticus. Gene. 569(1):141-52
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Zhao, Y., Zhang, K., Giesy, J.P., Hu, J. (2015) Families of Nuclear Receptors in Vertebrate Models: Characteristic and Comparative Toxicological Perspective. Scientific Reports. 5:8554
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