Gene
lhx4
- ID
- ZDB-GENE-060728-1
- Name
- LIM homeobox 4
- Symbol
- lhx4 Nomenclature History
- Previous Names
-
- si:dkeyp-35f11.3
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II regulatory region sequence-specific DNA binding activity. Involved in ventral spinal cord interneuron specification. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in panhypopituitarism. Is expressed in adenohypophyseal placode; nervous system; spinal cord neural keel; and spinal cord neural tube. Orthologous to human LHX4 (LIM homeobox 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
hypopituitarism | Alliance | Pituitary hormone deficiency, combined, 4 | 262700 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR017970 | Homeobox, conserved site |
Domain | IPR001356 | Homeodomain |
Domain | IPR001781 | Zinc finger, LIM-type |
Domain | IPR047956 | LIM/homeobox protein Lhx4, LIM domain 1 |
Domain | IPR049594 | LIM/homeobox protein Lhx3/4-like, LIM domain 2 |
Family | IPR050453 | LIM/homeobox transcription factors |
Homologous_superfamily | IPR009057 | Homedomain-like superfamily |
Domain Details Per Protein
Protein | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | LIM/homeobox protein Lhx3/4-like, LIM domain 2 | LIM/homeobox protein Lhx4, LIM domain 1 | LIM/homeobox transcription factors | Zinc finger, LIM-type |
---|---|---|---|---|---|---|---|---|
UniProtKB:B0S5S7
|
391 | |||||||
UniProtKB:A0A8M9PR07
|
270 |
Interactions and Pathways
No data available
Plasmids
No data available