Gene
sec14l8
- ID
- ZDB-GENE-060526-180
- Name
- SEC14-like lipid binding 8
- Symbol
- sec14l8 Nomenclature History
- Previous Names
-
- si:ch211-89f7.1
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Enables GTP binding activity; GTPase activating protein binding activity; and GTPase activity. Acts upstream of or within with a positive effect on angioblast cell migration from lateral mesoderm to midline. Acts upstream of or within Wnt signaling pathway, calcium modulating pathway; positive regulation of epiboly involved in gastrulation with mouth forming second; and regulation of convergent extension involved in axis elongation. Located in plasma membrane. Is expressed in blastomere; posterior cardinal vein; trunk vasculature; vascular cord; and vasculature. Orthologous to several human genes including SEC14L2 (SEC14 like lipid binding 2) and SEC14L3 (SEC14 like lipid binding 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001251 | CRAL-TRIO lipid binding domain |
| Domain | IPR009038 | GOLD domain |
| Domain | IPR011074 | CRAL/TRIO, N-terminal domain |
| Family | IPR051064 | SEC14-like and CRAL-TRIO domain-containing protein |
| Homologous_superfamily | IPR036273 | CRAL/TRIO, N-terminal domain superfamily |
| Homologous_superfamily | IPR036598 | GOLD domain superfamily |
| Homologous_superfamily | IPR036865 | CRAL-TRIO lipid binding domain superfamily |
Domain Details Per Protein
| Protein | Length | CRAL-TRIO lipid binding domain | CRAL-TRIO lipid binding domain superfamily | CRAL/TRIO, N-terminal domain | CRAL/TRIO, N-terminal domain superfamily | GOLD domain | GOLD domain superfamily | SEC14-like and CRAL-TRIO domain-containing protein |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A2BIR0
|
395 | |||||||
|
UniProtKB:A0A8M3ARZ3
|
261 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
sec14l8-201
(1)
|
Ensembl | 2,353 nt | ||
| ncRNA |
sec14l8-002
(1)
|
Ensembl | 822 nt |
Interactions and Pathways
No data available
Plasmids
No data available