Gene
sec14l8
- ID
- ZDB-GENE-060526-180
- Name
- SEC14-like lipid binding 8
- Symbol
- sec14l8 Nomenclature History
- Previous Names
-
- si:ch211-89f7.1
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Enables GTP binding activity; GTPase activating protein binding activity; and GTPase activity. Acts upstream of or within with a positive effect on angioblast cell migration from lateral mesoderm to midline. Acts upstream of or within Wnt signaling pathway, calcium modulating pathway; positive regulation of epiboly involved in gastrulation with mouth forming second; and regulation of convergent extension involved in axis elongation. Located in plasma membrane. Is expressed in blastomere; posterior cardinal vein; trunk vasculature; vascular cord; and vasculature. Orthologous to several human genes including SEC14L2 (SEC14 like lipid binding 2) and SEC14L3 (SEC14 like lipid binding 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa20358 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| tsu16 | Allele with one deletion | Start Codon | Start Loss | TALEN | |
| tsu17 | Allele with one deletion | Start Codon | Start Loss | TALEN | |
| tsu18 | Allele with one deletion | Start Codon | Start Loss | TALEN | |
| tsu19 | Allele with one deletion | Start Codon | Start Loss | TALEN | |
| tsu36cd | Allele with one deletion | Exon 5 | Premature Stop | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-sec14l8 | Gong et al., 2019 | |
| MO1-sec14l8 | N/A | Gong et al., 2017 |
| MO2-sec14l8 | N/A | (2) |
| MO3-sec14l8 | N/A | Gong et al., 2019 |
| TALEN1-sec14l8 | Gong et al., 2017 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001251 | CRAL-TRIO lipid binding domain |
| Domain | IPR009038 | GOLD domain |
| Domain | IPR011074 | CRAL/TRIO, N-terminal domain |
| Family | IPR051064 | SEC14-like and CRAL-TRIO domain-containing protein |
| Homologous_superfamily | IPR036273 | CRAL/TRIO, N-terminal domain superfamily |
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Domain Details Per Protein
| Protein | Length | CRAL-TRIO lipid binding domain | CRAL-TRIO lipid binding domain superfamily | CRAL/TRIO, N-terminal domain | CRAL/TRIO, N-terminal domain superfamily | GOLD domain | GOLD domain superfamily | SEC14-like and CRAL-TRIO domain-containing protein |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A2BIR0
|
395 | |||||||
|
UniProtKB:A0A8M3ARZ3
|
261 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
sec14l8-201
(1)
|
Ensembl | 2,353 nt | ||
| ncRNA |
sec14l8-002
(1)
|
Ensembl | 822 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-42H14 | ZFIN Curated Data | |
| Contained in | BAC | CH211-89F7 | ZFIN Curated Data | |
| Encodes | EST | fm06b11 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001099993 (1) | 1188 nt | ||
| Genomic | GenBank:BX957246 (2) | 186135 nt | ||
| Polypeptide | UniProtKB:A2BIR0 (1) | 395 aa |
No data available
- Gong, B., Guo, Y., Ding, S., Liu, X., Meng, A., Li, D., Jia, S. (2021) A Golgi-derived vesicle potentiates PtdIns4P to PtdIns3P conversion for endosome fission. Nature cell biology. 23:782-795
- Gong, B., Li, Z., Xiao, W., Li, G., Ding, S., Meng, A., Jia, S. (2019) Sec14l3 potentiates VEGFR2 signaling to regulate zebrafish vasculogenesis. Nature communications. 10:1606
- Gong, B., Shen, W., Xiao, W., Meng, Y., Meng, A., Jia, S. (2017) The Sec14-like phosphatidylinositol transfer proteins Sec14l3/SEC14L2 act as GTPase proteins to mediate Wnt/Ca2+ signaling.. eLIFE. 6
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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