Gene
qdprb.1
- ID
- ZDB-GENE-050522-320
- Name
- quinoid dihydropteridine reductase b, tandem duplicate 1
- Symbol
- qdprb.1 Nomenclature History
- Previous Names
-
- qdprb1
- si:dkey-92j12.1
- wu:fj24b09
- zgc:101857
- zgc:112405
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Enables 6,7-dihydropteridine reductase activity. Acts upstream of or within brain development; gliogenesis; and glutamine metabolic process. Predicted to be active in cytoplasm. Is expressed in ciliary marginal zone; eye; midbrain hindbrain boundary; optic tectum; and retina. Human ortholog(s) of this gene implicated in BH4-deficient hyperphenylalaninemia C and phenylketonuria. Orthologous to human QDPR (quinoid dihydropteridine reductase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:101857 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 7 figures from Breuer et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-qdprb.1 | (2) | |
| MO1-qdprb.1 | N/A | Breuer et al., 2019 |
| MO2-qdprb.1 | N/A | Breuer et al., 2019 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| BH4-deficient hyperphenylalaninemia C | Alliance | Hyperphenylalaninemia, BH4-deficient, C | 261630 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | NAD-dependent epimerase/dehydratase | NAD(P)-binding domain superfamily |
|---|---|---|---|---|
| UniProtKB:Q66IB5 | InterPro | 239 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
qdprb1-201
(1)
|
Ensembl | 1,025 nt | ||
| ncRNA |
qdprb1-002
(1)
|
Ensembl | 912 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-101B14 | ||
| Contained in | BAC | DKEY-92J12 | ZFIN Curated Data | |
| Encodes | EST | fj24b09 | ||
| Encodes | cDNA | MGC:101857 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:112405 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192337 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001020698 (1) | 979 nt | ||
| Genomic | GenBank:AL929074 (1) | 165705 nt | ||
| Polypeptide | UniProtKB:Q66IB5 (1) | 239 aa |
- Banu, S., Gaur, N., Nair, S., Ravikrishnan, T., Khan, S., Mani, S., Bharathi, S., Mandal, K., Kuram, N.A., Vuppaladadium, S., Ravi, R., Murthy, C.L.N., Quoseena, M., Babu, N.S., Idris, M.M. (2022) Transcriptomic and proteomic analysis of epimorphic regeneration in zebrafish caudal fin tissue. Genomics. 114(2):110300
- Breuer, M., Guglielmi, L., Zielonka, M., Hemberger, V., Kölker, S., Okun, J.G., Hoffmann, G.F., Carl, M., Sauer, S.W., Opladen, T. (2019) QDPR homologues in Danio rerio regulate melanin synthesis, early gliogenesis, and glutamine homeostasis. PLoS One. 14:e0215162
- Jiang, Y., Li, J., Ren, F., Ji, C., Aniagu, S., Chen, T. (2019) PM2.5-induced extensive DNA methylation changes in the heart of zebrafish embryos and the protective effect of folic acid. Environmental pollution (Barking, Essex : 1987). 255:113331
- Sun, Y., Zhang, B., Luo, L., Shi, D.L., Wang, H., Cui, Z., Huang, H., Cao, Y., Shu, X., Zhang, W., Zhou, J., Li, Y., Du, J., Zhao, Q., Chen, J., Zhong, H., Zhong, T.P., Li, L., Xiong, J.W., Peng, J., Xiao, W., Zhang, J., Yao, J., Yin, Z., Mo, X., Peng, G., Zhu, J., Chen, Y., Zhou, Y., Liu, D., Pan, W., Zhang, Y., Ruan, H., Liu, F., Zhu, Z., Meng, A., ZAKOC Consortium (2019) Systematic genome editing of the genes on zebrafish Chromosome 1 by CRISPR/Cas9. Genome research. 30(1):118-26
- Braasch, I., Brunet, F., Volff, J.N., and Schartl, M. (2009) Pigmentation pathway evolution after whole-genome duplication in fish. Genome biology and evolution. 1:479-493
- Braasch, I., Schartl, M., and Volff, J.N. (2007) Evolution of pigment synthesis pathways by gene and genome duplication in fish. BMC Evolutionary Biology. 7(1):74
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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