Gene
ncapd2
- ID
- ZDB-GENE-050506-59
- Name
- non-SMC condensin I complex, subunit D2
- Symbol
- ncapd2 Nomenclature History
- Previous Names
-
- cap-d2 (1)
- im:6902697
- si:dkey-175g20.1
- wu:fc13f08
- wu:fx06e10
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to have chromatin binding activity and histone binding activity. Involved in mitotic sister chromatid segregation. Predicted to localize to condensed chromosome, centromeric region and nuclear condensin complex. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly. Is expressed in nervous system; optic cup; pectoral fin; pharyngeal arch 3-7 skeleton; and proliferative region. Orthologous to human NCAPD2 (non-SMC condensin I complex subunit D2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6902697 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Seipold et al., 2009
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Microcephaly 21, primary, autosomal recessive | 617983 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR024324 | Condensin complex subunit 1, N-terminal |
| Domain | IPR032682 | Condensin complex subunit 1, C-terminal |
| Family | IPR007673 | Condensin subunit 1 |
| Family | IPR026971 | Condensin subunit 1/Condensin-2 complex subunit D3 |
| Homologous_superfamily | IPR011989 | Armadillo-like helical |
| Homologous_superfamily | IPR016024 | Armadillo-type fold |
Domain Details Per Protein
| Protein | Length | Armadillo-like helical | Armadillo-type fold | Condensin complex subunit 1, C-terminal | Condensin complex subunit 1, N-terminal | Condensin subunit 1 | Condensin subunit 1/Condensin-2 complex subunit D3 |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M1NUS6
|
1380 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ncapd2-201
(1)
|
Ensembl | 4,412 nt | ||
| mRNA |
ncapd2-203
(1)
|
Ensembl | 5,497 nt | ||
| ncRNA |
ncapd2-002
(1)
|
Ensembl | 746 nt |
Interactions and Pathways
No data available
Plasmids
No data available