Gene
ptprq
- ID
- ZDB-GENE-050419-183
- Name
- protein tyrosine phosphatase receptor type Q
- Symbol
- ptprq Nomenclature History
- Previous Names
-
- si:ch211-11f8.3 (1)
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable histone H2AXY142 phosphatase activity; non-membrane spanning protein tyrosine phosphatase activity; and protein tyrosine phosphatase activity, metal-dependent. Predicted to act upstream of or within protein dephosphorylation. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 73 and autosomal recessive nonsyndromic deafness 84A. Orthologous to human PTPRQ (protein tyrosine phosphatase receptor type Q).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from van Eekelen et al., 2010
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa23213 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa23214 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa32184 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa43034 | Allele with one point mutation | Unknown | Splice Site | ENU |
1 - 4 of 4
Show
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-ptprq | (3) | |
| CRISPR2-ptprq | Varshney et al., 2015 | |
| CRISPR3-ptprq | (4) |
1 - 3 of 3
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant nonsyndromic deafness 73 | Alliance | Deafness, autosomal dominant 73 | 617663 |
| autosomal recessive nonsyndromic deafness 84A | Alliance | Deafness, autosomal recessive 84A | 613391 |
1 - 2 of 2
Domain, Family, and Site Summary
No data available
Domain Details Per Protein
No data available
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-11F8 | ZFIN Curated Data |
1 - 1 of 1
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_068214993 (1) | 10534 nt | ||
| Genomic | GenBank:AL928990 (1) | 185618 nt | ||
| Polypeptide | RefSeq:XP_068071094 (1) |
- Varshney, G.K., Zhang, S., Pei, W., Adomako-Ankomah, A., Fohtung, J., Schaffer, K., Carrington, B., Maskeri, A., Slevin, C., Wolfsberg, T., Ledin, J., Sood, R., Burgess, S.M. (2016) CRISPRz: a database of zebrafish validated sgRNAs. Nucleic acids research. 44(D1):D822-6
- Carrington, B., Varshney, G.K., Burgess, S.M., Sood, R. (2015) CRISPR-STAT: an easy and reliable PCR-based method to evaluate target-specific sgRNA activity. Nucleic acids research. 43(22):e157
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Pei, W., LaFave, M.C., Idol, J., Xu, L., Gallardo, V., Carrington, B., Bishop, K., Jones, M., Li, M., Harper, U., Huang, S.C., Prakash, A., Chen, W., Sood, R., Ledin, J., Burgess, S.M. (2015) High-throughput gene targeting and phenotyping in zebrafish using CRISPR/Cas9. Genome research. 25(7):1030-42
- Overman, J.P., and den Hertog, J. (2014) Zebrafish as a model to study PTPs during development. Methods (San Diego, Calif.). 65(2):247-53
- van Eekelen, M., Overvoorde, J., van Rooijen, C., and den Hertog, J. (2010) Identification and expression of the family of classical protein-tyrosine phosphatases in zebrafish. PLoS One. 5(9):e12573
1 - 6 of 6
Show