Gene
krt92
- ID
- ZDB-GENE-050417-363
- Name
- keratin 92
- Symbol
- krt92 Nomenclature History
- Previous Names
-
- si:dkeyp-113d7.5
- zgc:109868
- zgc:136388
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable structural molecule activity. Predicted to be located in intermediate filament. Predicted to be active in cytoskeleton. Human ortholog(s) of this gene implicated in several diseases, including ectodermal dysplasia (multiple); focal nonepidermolytic palmoplantar keratoderma 1; pachyonychia congenita; steatocystoma multiplex; and white sponge nevus 2. Orthologous to several human genes including KRT13 (keratin 13); KRT14 (keratin 14); and KRT15 (keratin 15).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ki126Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR | |
| sa10798 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa12647 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa15492 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa23426 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Intermediate filament, rod domain | Keratin, type I |
|---|---|---|---|---|
| UniProtKB:Q1LXJ8 | InterPro | 390 | ||
| UniProtKB:F1Q7G3 | InterPro | 431 | ||
| UniProtKB:A0A0N4SUF2 | InterPro | 433 | ||
| UniProtKB:Q568U3 | InterPro | 430 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-113D7 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:109868 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:136388 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:158600 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001017824 (1) | 1420 nt | ||
| Genomic | GenBank:BX323079 (1) | 165200 nt | ||
| Polypeptide | UniProtKB:A0A0N4SUF2 (1) | 433 aa |
No data available
- Mi, J., Andersson, O. (2023) Efficient knock-in method enabling lineage tracing in zebrafish. Life science alliance. 6(5)
- Ho, M., Thompson, B., Fisk, J.N., Nebert, D.W., Bruford, E.A., Vasiliou, V., Bunick, C.G. (2022) Update of the keratin gene family: evolution, tissue-specific expression patterns, and relevance to clinical disorders. Human genomics. 16:1
- Cokus, S.J., De La Torre, M., Medina, E.F., Rasmussen, J.P., Ramirez-Gutierrez, J., Sagasti, A., Wang, F. (2019) Tissue-Specific Transcriptomes Reveal Gene Expression Trajectories in Two Maturing Skin Epithelial Layers in Zebrafish Embryos. G3 (Bethesda). 9(10):3439-3452
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Gündel, U., Kalkhof, S., Zitzkat, D., von Bergen, M., Altenburger, R., and Küster, E. (2012) Concentration-response concept in ecotoxicoproteomics: Effects of different phenanthrene concentrations to the zebrafish (Danio rerio) embryo proteome. Ecotoxicology and environmental safety. 76(2):11-22
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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