Gene
slc17a7a
- ID
- ZDB-GENE-050105-5
- Name
- solute carrier family 17 member 7a
- Symbol
- slc17a7a Nomenclature History
- Previous Names
-
- slc17a7
- vglut1 (3)
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable L-glutamate transmembrane transporter activity and neurotransmitter transmembrane transporter activity. Predicted to be involved in glutamatergic synaptic transmission; neurotransmitter loading into synaptic vesicle; and regulation of synapse structure or activity. Predicted to act upstream of or within several processes, including chloride transport; neurotransmitter transport; and sodium ion transport. Predicted to be located in several cellular components, including cytoplasmic vesicle; neuron projection; and synapse. Predicted to be part of chloride channel complex. Predicted to be active in excitatory synapse and synaptic vesicle membrane. Is expressed in nervous system and otic vesicle. Orthologous to human SLC17A7 (solute carrier family 17 member 7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 23 figures from 14 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Obholzer et al., 2008
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Major facilitator superfamily | Major facilitator superfamily domain | Major Facilitator Superfamily Sodium/Anion Cotransporter | MFS transporter superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:A3QK31 | InterPro | 582 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slc17a7a-201
(1)
|
Ensembl | 1,820 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-slc17a7 | polyclonal | Rabbit |
|
13 |
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(hsp70l:slc17a7a-PAFMA,myl7:EGFP) |
| 1 | Vaithianathan et al., 2016 | ||
| Tg(hsp70l:slc17a7a-pHGFP,myl7:EGFP) |
| 1 | Vaithianathan et al., 2016 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-29B22 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:163045 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001098755 (1) | 1820 nt | ||
| Genomic | GenBank:BX936358 (1) | 165674 nt | ||
| Polypeptide | UniProtKB:A3QK31 (1) | 582 aa |
- Ariani, A., Khotimah, H., Sulistyarini, A., Daniaridevi, A.S. (2024) Centella asiatica extract ameliorates deoxygenation-induced neurological dysfunction in zebrafish larvae. Open veterinary journal. 14:115411601154-1160
- Baker, C.E., Marta, A.G., Zimmerman, N.D., Korade, Z., Mathy, N.W., Wilton, D., Simeone, T., Kochvar, A., Kramer, K.L., Stessman, H.A.F., Shibata, A. (2024) CPT2 Deficiency Modeled in Zebrafish: Abnormal Neural Development, Electrical Activity, Behavior, and Schizophrenia-Related Gene Expression. Biomolecules. 14(8):
- Itoh, T., Uehara, M., Yura, S., Wang, J.C., Fujii, Y., Nakanishi, A., Shimizu, T., Hibi, M. (2024) Foxp- and Skor-family proteins control differentiation of Purkinje cells from Ptf1a and Neurogenin1-expressing progenitors in zebrafish. Development (Cambridge, England). 151(7):
- Muscò, A., Martini, D., Digregorio, M., Broccoli, V., Andreazzoli, M. (2024) Shedding a Light on Dark Genes: A Comparative Expression Study of PRR12 Orthologues during Zebrafish Development. Genes. 15(4):
- Naderi, M., Nguyen, T.M.N., Pompili, C., Kwong, R.W.M. (2024) Unraveling the socio-cognitive consequences of KCC2 disruption in zebrafish: implications for neurodevelopmental disorders and therapeutic interventions. Frontiers in molecular neuroscience. 17:14832381483238
- Wang, Y., Sun, X., Xiong, B., Duan, M., Sun, Y. (2024) Genetic and Environmental Factors Co-Contributing to Behavioral Abnormalities in adnp/adnp2 Mutant Zebrafish. International Journal of Molecular Sciences. 25(17):
- Zhao, S., Wang, C., Luo, H., Li, F., Wang, Q., Xu, J., Huang, Z., Liu, W., Zhang, W. (2024) A role for Retinoblastoma 1 in hindbrain morphogenesis by regulating GBX family. Journal of genetics and genomics = Yi chuan xue bao. 51(9):900-910
- Berg, E.M., Mrowka, L., Bertuzzi, M., Madrid, D., Picton, L.D., El Manira, A. (2022) Brainstem circuits encoding start, speed, and duration of swimming in adult zebrafish. Neuron. 111(3):372-386.e4
- Ikeda, A., Yamasaki, C., Kubo, Y., Doi, Y., Komamizu, M., Komatsu, M., Shiozaki, K. (2022) Alteration of the neuronal and glial cell profiles in Neu1-deficient zebrafish. Glycoconjugate journal. 39(4):499-512
- Long, F., Zheng, J., Zhou, J., Hu, P., Xiong, B. (2022) Knockout of tanc2 causes autism-like behavior and sleep disturbance in zebrafish. Autism research : official journal of the International Society for Autism Research. 16(3):524-534
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