Gene
fmn1
- ID
- ZDB-GENE-041001-198
- Name
- formin 1
- Symbol
- fmn1 Nomenclature History
- Previous Names
-
- si:dkey-81b15.10
- Type
- protein_coding_gene
- Location
- Ambiguous Mapping Details/Browsers
- Description
- Predicted to enable microtubule binding activity. Predicted to be involved in actin cytoskeleton organization. Predicted to act upstream of or within actin nucleation. Predicted to be located in actin filament. Predicted to be active in endoplasmic reticulum membrane and nucleus. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human FMN1 (formin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Lau et al., 2016
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la021518Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa1135 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa11299 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa39286 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa43462 | Allele with one point mutation | Unknown | Premature Stop | ENU |
1 - 5 of 5
Show
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Formin, FH2 domain | Formin, FH2 domain superfamily | Formin homology family, Cappuccino subfamily |
|---|---|---|---|---|---|
| UniProtKB:A0A8N7UUW0 | InterPro | 1365 |
1 - 1 of 1
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cu695215.2-201
(1)
|
Ensembl | 2,873 nt | ||
| mRNA |
fmn1-201
(1)
|
Ensembl | 4,244 nt |
1 - 2 of 2
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-187M15 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-81B15 | ZFIN Curated Data |
1 - 2 of 2
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_684477 (1) | 5244 nt | ||
| Genomic | GenBank:BX248136 (1) | 222316 nt | ||
| Polypeptide | UniProtKB:A0A8N7UUW0 (1) | 1365 aa |
- Witjes, L., Van Troys, M., Vandekerckhove, J., Vandepoele, K., Ampe, C. (2019) A new evolutionary model for the vertebrate actin family including two novel groups. Molecular phylogenetics and evolution. 141:106632
- Lau, M.C., Kwong, E.M., Lai, K.P., Li, J.W., Ho, J.C., Chan, T.F., Wong, C.K., Jiang, Y.J., Tse, W.K. (2016) Pathogenesis of POLR1C-dependent type 3 treacher Collins syndrome revealed by a zebrafish model. Biochimica et biophysica acta. Molecular basis of disease. 1862(6):1147-58
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
1 - 4 of 4
Show