Gene
sart3
- ID
- ZDB-GENE-040724-10
- Name
- spliceosome associated factor 3, U4/U6 recycling protein
- Symbol
- sart3 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable U6 snRNA binding activity and histone binding activity. Involved in spliceosomal snRNP assembly. Acts upstream of or within several processes, including exocrine pancreas development; spliceosomal complex assembly; and thymus development. Predicted to be located in Cajal body. Predicted to be part of ASAP complex. Predicted to be active in cytoplasm and nucleoplasm. Orthologous to human SART3 (spliceosome associated factor 3, U4/U6 recycling protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7151848 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 14 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
cz3 | Allele with one insertion | Unknown | Unknown | ENU | |
cz5 | Allele with one insertion | Unknown | Unknown | ENU | |
cz11 | Allele with one insertion | Unknown | Unknown | ENU | |
la010960Tg | Transgenic insertion | Unknown | Unknown | DNA | |
la015580Tg | Transgenic insertion | Unknown | Unknown | DNA | |
sa6968 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa31425 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa33571 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sm471 | Allele with one point mutation | Exon 6 | Premature Stop | ENU | |
szy4 | Allele with one delins | Exon 1 | Unknown | CRISPR |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-sart3 | (2) | |
CRISPR2-sart3 | Zhao et al., 2021 | |
MO1-sart3 | N/A | Trede et al., 2007 |
MO2-sart3 | N/A | Trede et al., 2007 |
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Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR000504 | RNA recognition motif domain |
Domain | IPR008847 | Suppressor of forked |
Domain | IPR034217 | SART3, RNA recognition motif 1 |
Domain | IPR034218 | SART3, RNA recognition motif 2 |
Homologous_superfamily | IPR011990 | Tetratricopeptide-like helical domain superfamily |
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Domain Details Per Protein
Protein | Length | HAT (Half-A-TPR) repeat | Nucleotide-binding alpha-beta plait domain superfamily | RNA-binding domain superfamily | RNA recognition motif domain | SART3, RNA recognition motif 1 | SART3, RNA recognition motif 2 | Suppressor of forked | Tetratricopeptide-like helical domain superfamily |
---|---|---|---|---|---|---|---|---|---|
UniProtKB:Q6ZM52
|
951 | ||||||||
UniProtKB:B3DJT0
|
951 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-191D15 | ||
Encodes | EST | fc51h03 | ZFIN Curated Data | |
Encodes | EST | IMAGE:7151848 | Thisse et al., 2004 | |
Encodes | cDNA | MGC:171809 | ZFIN Curated Data | |
Encodes | cDNA | MGC:195242 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001030118 (1) | 4657 nt | ||
Genomic | GenBank:AL845326 (1) | 143528 nt | ||
Polypeptide | UniProtKB:B3DJT0 (1) | 951 aa |
- Zhao, Y., Wu, M., Li, J., Meng, P., Chen, J., Huang, Z., Xu, J., Wen, Z., Zhang, W., Zhang, Y. (2021) The spliceosome factor sart3 regulates hematopoietic stem/progenitor cell development in zebrafish through the p53 pathway. Cell Death & Disease. 12:906
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Iwanami, N. (2014) Zebrafish as a model for understanding the evolution of the vertebrate immune system and human primary immunodeficiency. Experimental hematology. 42(8):697-706
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, K., Huang, Z., Zhao, L., Liu, W., Chen, X., Meng, P., Lin, Q., Chi, Y., Xu, M., Ma, N., Zhang, Y., and Zhang, W. (2012) Large-scale forward genetic screening analysis of development of hematopoiesis in zebrafish. Journal of genetics and genomics = Yi chuan xue bao. 39(9):473-480
- Trede, N.S., Ota, T., Kawasaki, H., Paw, B.H., Katz, T., Demarest, B., Hutchinson, S., Zhou, Y., Hersey, C., Zapata, A., Amemiya, C.T., and Zon, L.I. (2008) Zebrafish mutants with disrupted early T-cell and thymus development identified in early pressure screen. Developmental Dynamics : an official publication of the American Association of Anatomists. 237(9):2575-2584
- Trede, N.S., Medenbach, J., Damianov, A., Hung, L.H., Weber, G.J., Paw, B.H., Zhou, Y., Hersey, C., Zapata, A., Keefe, M., Barut, B.A., Stuart, A.B., Katz, T., Amemiya, C.T., Zon, L.I., and Bindereif, A. (2007) Network of coregulated spliceosome components revealed by zebrafish mutant in recycling factor p110. Proceedings of the National Academy of Sciences of the United States of America. 104(16):6608-6613
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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