UniProt ID: B3DJT0 |
FUNCTION: U6 snRNP-binding protein that functions as a recycling factor of the splicing machinery. Promotes the initial reassembly of U4 and U6 snRNPs following their ejection from the spliceosome during its maturation (PubMed:17416673). May also function as a substrate targeting factor for deubiquitinases and mediate the deubiquitination of components of the spliceosome and histones (By similarity). {ECO:0000250|UniProtKB:Q15020, ECO:0000269|PubMed:17416673}. SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q15020}. Nucleus, Cajal body {ECO:0000250|UniProtKB:Q15020}. Nucleus speckle {ECO:0000250|UniProtKB:Q15020}. Cytoplasm {ECO:0000250|UniProtKB:Q15020}. DISRUPTION PHENOTYPE: The egy mutant embryos that lack detectable sart3 expression display microcephaly, microphthalmia and die by 7 to 8 dpf. Pharyngeal arch formation is defective resulting in a thymus devoid of lymphocytes and exocrine pancreas development is also impaired. {ECO:0000269|PubMed:17416673}. |
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