Gene
hdac8
- ID
- ZDB-GENE-040426-2772
- Name
- histone deacetylase 8
- Symbol
- hdac8 Nomenclature History
- Previous Names
-
- wu:fd19a02
- zgc:66196 (1)
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable histone deacetylase activity and histone decrotonylase activity. Acts upstream of or within central nervous system development and neuron cellular homeostasis. Predicted to be located in several cellular components, including chromosome; nucleus; and plasma membrane. Is expressed in several structures, including brain; fin bud; gut; muscle; and oocyte. Used to study Cornelia de Lange syndrome. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 5 and Wilson-Turner syndrome. Orthologous to human HDAC8 (histone deacetylase 8).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7144626 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la026136Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa10754 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa14948 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa31597 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa44675 | Allele with one point mutation | Unknown | Unknown | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Cornelia de Lange syndrome 5 | Alliance | Cornelia de Lange syndrome 5 | 300882 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| Cornelia de Lange syndrome | AB + MO2-hdac8 | standard conditions | Bottai et al., 2018 |
| Cornelia de Lange syndrome | AB + MO3-hdac8 | standard conditions | Bottai et al., 2018 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR011613 | GH15-like domain |
| Domain | IPR023801 | Histone deacetylase domain |
| Domain | IPR045583 | Phosphorylase b kinase regulatory subunit alpha/beta, C-terminal domain |
| Family | IPR000286 | Histone deacetylase family |
| Family | IPR003084 | Histone deacetylase |
| Family | IPR008734 | Phosphorylase kinase alpha/beta subunit |
| Family | IPR050284 | Histone deacetylase and polyamine deacetylase |
| Homologous_superfamily | IPR008928 | Six-hairpin glycosidase superfamily |
| Homologous_superfamily | IPR012341 | Six-hairpin glycosidase-like superfamily |
| Homologous_superfamily | IPR023696 | Ureohydrolase domain superfamily |
| Homologous_superfamily | IPR037138 | Histone deacetylase domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | GH15-like domain | Histone deacetylase | Histone deacetylase and polyamine deacetylase | Histone deacetylase domain | Histone deacetylase domain superfamily | Histone deacetylase family | Phosphorylase b kinase regulatory subunit alpha/beta, C-terminal domain | Phosphorylase kinase alpha/beta subunit | Six-hairpin glycosidase-like superfamily | Six-hairpin glycosidase superfamily | Ureohydrolase domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q7SXM0 | InterPro | 378 | |||||||||||
| UniProtKB:A0A8M2BE34 | InterPro | 311 | |||||||||||
| UniProtKB:A0A286YAZ5 | InterPro | 1232 | |||||||||||
| UniProtKB:E7F4R5 | InterPro | 1219 |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-hdac8 | polyclonal | IgG | Rabbit |
|
Santa Cruz Biotechnology, Inc.
|
4 |
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-29B6 | ZFIN Curated Data | |
| Encodes | EST | fd19a02 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7144626 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:66196 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_213431 (1) | 1935 nt | ||
| Genomic | GenBank:CR318655 (1) | 247390 nt | ||
| Polypeptide | UniProtKB:A0A286YAZ5 (1) | 1232 aa |
- Volpatti, J.R., Ghahramani-Seno, M.M., Mansat, M., Sabha, N., Sarikaya, E., Goodman, S.J., Chater-Diehl, E., Celik, A., Pannia, E., Froment, C., Combes-Soia, L., Maani, N., Yuki, K.E., Chicanne, G., Uusküla-Reimand, L., Monis, S., Alvi, S.A., Genetti, C.A., Payrastre, B., Beggs, A.H., Bonnemann, C.G., Muntoni, F., Wilson, M.D., Weksberg, R., Viaud, J., Dowling, J.J. (2022) X-linked myotubular myopathy is associated with epigenetic alterations and is ameliorated by HDAC inhibition. Acta Neuropathologica. 144(3):537-563
- Zhuang, M., Scholz, A., Walz, G., Yakulov, T.A. (2022) Histone Deacetylases Cooperate with NF-κB to Support the Immediate Migratory Response after Zebrafish Pronephros Injury. International Journal of Molecular Sciences. 23(17)
- Liu, C., Wang, Y., Deng, J., Lin, J., Hu, C., Li, Q., Xu, X. (2021) Social Deficits and Repetitive Behaviors Are Improved by Early Postnatal Low-Dose VPA Intervention in a Novel shank3-Deficient Zebrafish Model. Frontiers in neuroscience. 15:682054
- Spreafico, M., Cafora, M., Bragato, C., Capitanio, D., Marasca, F., Bodega, B., De Palma, C., Mora, M., Gelfi, C., Marozzi, A., Pistocchi, A. (2021) Targeting HDAC8 to ameliorate skeletal muscle differentiation in Duchenne muscular dystrophy. Pharmacological research. 170:105750
- Spreafico, M., Gruszka, A.M., Valli, D., Mazzola, M., Deflorian, G., Quintè, A., Totaro, M.G., Battaglia, C., Alcalay, M., Marozzi, A., Pistocchi, A. (2020) HDAC8: A Promising Therapeutic Target for Acute Myeloid Leukemia. Frontiers in cell and developmental biology. 8:844
- Fellous, A., Earley, R.L., Silvestre, F. (2019) Identification and expression of mangrove rivulus (Kryptolebias marmoratus) histone deacetylase (Hdac) and lysine acetyltransferase (Kat) genes. Gene. 691:56-69
- Bottai, D., Spreafico, M., Pistocchi, A., Fazio, G., Adami, R., Grazioli, P., Canu, A., Bragato, C., Rigamonti, S., Parodi, C., Cazzaniga, G., Biondi, A., Cotelli, F., Selicorni, A., Massa, V. (2018) Modeling Cornelia de Lange Syndrome in vitro and in vivo reveals a role for cohesin complex in neuronal survival and differentiation. Human molecular genetics. 28(1):64-73
- Ferrari, L., Bragato, C., Brioschi, L., Spreafico, M., Esposito, S., Pezzotta, A., Pizzetti, F., Moreno-Fortuny, A., Bellipanni, G., Giordano, A., Riva, P., Frabetti, F., Viani, P., Cossu, G., Mora, M., Marozzi, A., Pistocchi, A. (2018) HDAC8 regulates canonical Wnt pathway to promote differentiation in skeletal muscles. Journal of Cellular Physiology. 234(5):6067-6076
- Mitra, S., Sharma, P., Kaur, S., Khursheed, M.A., Gupta, S., Ahuja, R., Kurup, A.J., Chaudhary, M., Ramachandran, R. (2018) Histone Deacetylase-Mediated Müller Glia Reprogramming through Her4.1-Lin28a Axis Is Essential for Retina Regeneration in Zebrafish. iScience. 7:68-84
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
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