Gene

zgc:77938

ID

ZDB-GENE-040426-1910

Name

zgc:77938

Symbol

zgc:77938 Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 14 Mapping Details/Browsers

Description

Predicted to have S-(hydroxymethyl)glutathione dehydrogenase activity; alcohol dehydrogenase activity, zinc-dependent; and zinc ion binding activity. Predicted to be involved in formaldehyde catabolic process. Predicted to localize to cytosol. Human ortholog(s) of this gene implicated in alcohol use disorder; late onset Parkinson's disease; and pancreatic cancer. Is expressed in intestinal bulb and liver. Orthologous to several human genes including ADH1A (alcohol dehydrogenase 1A (class I), alpha polypeptide); ADH1B (alcohol dehydrogenase 1B (class I), beta polypeptide); and ADH1C (alcohol dehydrogenase 1C (class I), gamma polypeptide).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

7 figures from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:77938 (7 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With zgc:77938 Human Ortholog

No data available

Associated With zgc:77938 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR002328	Alcohol dehydrogenase, zinc-type, conserved site
Domain	IPR013149	Alcohol dehydrogenase-like, C-terminal
Domain	IPR013154	Alcohol dehydrogenase-like, N-terminal
Domain	IPR020843	Polyketide synthase, enoylreductase domain
Homologous_superfamily	IPR011032	GroES-like superfamily
Homologous_superfamily	IPR036291	NAD(P)-binding domain superfamily