Gene
zgc:77938
- ID
- ZDB-GENE-040426-1910
- Name
- zgc:77938
- Symbol
- zgc:77938 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to have S-(hydroxymethyl)glutathione dehydrogenase activity; alcohol dehydrogenase activity, zinc-dependent; and zinc ion binding activity. Predicted to be involved in formaldehyde catabolic process. Predicted to localize to cytosol. Human ortholog(s) of this gene implicated in alcohol use disorder; late onset Parkinson's disease; and pancreatic cancer. Is expressed in intestinal bulb and liver. Orthologous to several human genes including ADH1A (alcohol dehydrogenase 1A (class I), alpha polypeptide); ADH1B (alcohol dehydrogenase 1B (class I), beta polypeptide); and ADH1C (alcohol dehydrogenase 1C (class I), gamma polypeptide).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:77938 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR002328 | Alcohol dehydrogenase, zinc-type, conserved site |
| Domain | IPR013149 | Alcohol dehydrogenase-like, C-terminal |
| Domain | IPR013154 | Alcohol dehydrogenase-like, N-terminal |
| Domain | IPR020843 | Polyketide synthase, enoylreductase domain |
| Homologous_superfamily | IPR011032 | GroES-like superfamily |
| Homologous_superfamily | IPR036291 | NAD(P)-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | Alcohol dehydrogenase-like, C-terminal | Alcohol dehydrogenase-like, N-terminal | Alcohol dehydrogenase, zinc-type, conserved site | GroES-like superfamily | NAD(P)-binding domain superfamily | Polyketide synthase, enoylreductase domain |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6NZZ1
|
378 | ||||||
|
UniProtKB:A0A8M2B456
|
431 |
| Type | Name | Annotation Method | Length (nt) | Analysis |
|---|---|---|---|---|
| mRNA |
zgc:77938-201
(1)
|
Havana | 1357 nt | |
| ncRNA |
zgc:77938-002
(1)
|
Havana | 776 nt |
Interactions and Pathways
No data available
Plasmids
No data available