Gene
gmps
- ID
- ZDB-GENE-040426-1503
- Name
- guanine monophosphate synthase
- Symbol
- gmps Nomenclature History
- Previous Names
-
- cb632 (1)
- sb:cb632
- wu:fb76b01
- wu:fi05a09
- zgc:66002
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable GMP synthase activity. Predicted to be involved in GMP biosynthetic process. Predicted to be active in cytosol. Is expressed in several structures, including alar plate midbrain region; digestive system; eye; midbrain; and segmental plate. Human ortholog(s) of this gene implicated in acute myelomonocytic leukemia. Orthologous to human GMPS (guanine monophosphate synthase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from Thisse et al., 2001
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb632 (16 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-gmps | Huang et al., 2025 | |
| MO1-gmps | N/A | Ng et al., 2009 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Class I glutamine amidotransferase-like | Glutamine amidotransferase | GMP synthase, C-terminal | GMP synthase, glutamine amidotransferase | GMP synthetase ATP pyrophosphatase domain | NAD/GMP synthase | Rossmann-like alpha/beta/alpha sandwich fold |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:B8JLW8 | InterPro | 692 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-5K23 | ZFIN Curated Data | |
| Encodes | EST | cb632 | Thisse et al., 2001 | |
| Encodes | EST | fb76b01 | ||
| Encodes | EST | fi05a09 | ||
| Encodes | cDNA | MGC:66002 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200587 (1) | 4089 nt | ||
| Genomic | GenBank:CU570794 (1) | 111313 nt | ||
| Polypeptide | UniProtKB:B8JLW8 (1) | 692 aa |
- Huang, D., Kapadia, E.H., Liang, Y., Shriver, L.P., Dai, S., Patti, G.J., Humbel, B.M., Laudet, V., Parichy, D.M. (2025) Agouti and BMP signaling drive a naturally occurring fate conversion of melanophores to leucophores in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 122:e2424180122e2424180122
- Lewis, V.M., Saunders, L.M., Larson, T.A., Bain, E.J., Sturiale, S.L., Gur, D., Chowdhury, S., Flynn, J.D., Allen, M.C., Deheyn, D.D., Lee, J.C., Simon, J.A., Lippincott-Schwartz, J., Raible, D.W., Parichy, D.M. (2019) Fate plasticity and reprogramming in genetically distinct populations of Danio leucophores. Proceedings of the National Academy of Sciences of the United States of America. 116(24):11806-11811
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Nussbaum, J.M., Liu, L.J., Hasan, S.A., Schaub, M., McClendon, A., Stainier, D.Y., and Sakaguchi, T.F. (2013) Homeostatic generation of reactive oxygen species protects the zebrafish liver from steatosis. Hepatology (Baltimore, Md.). 58(4):1326-1338
- Colanesi, S., Taylor, K.L., Temperley, N.D., Lundegaard, P.R., Liu, D., North, T.E., Ishizaki, H., Kelsh, R.N., and Patton, E.E. (2012) Small molecule screening identifies targetable zebrafish pigmentation pathways. Pigment cell & melanoma research. 25(2):131-143
- Ng, A., Uribe, R.A., Yieh, L., Nuckels, R., and Gross, J.M. (2009) Zebrafish mutations in gart and paics identify crucial roles for de novo purine synthesis in vertebrate pigmentation and ocular development. Development (Cambridge, England). 136(15):2601-2611
- Hashiguchi, Y., and Nishida, M. (2006) Evolution and origin of vomeronasal-type odorant receptor gene repertoire in fishes. BMC Evolutionary Biology. 6:76
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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