ZFIN ID: ZDB-GENE-040426-1435
Gene Name: integrin-linked kinase
Gene Symbol: ilk
Previous Names: loc, lost-contact, main squeeze, msq, zgc:65842, zilk (1)
Location: Chr: 10   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 11 figures from 7 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:65842]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
  blood vessel endothelial cell, brain, cardiac muscle cell Z disc, heart (all 15) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 7 Genotypes
Knockdown reagents: MO1-ilk (2), MO2-ilk (2), MO3-ilk (1), MO4-ilk (1)

Allele Type Mutagen Suppliers
hu801 Point Mutation
m347 Point Mutation ENU
PHENOTYPE
Data: 15 figures from 9 publications
Observed in: blood, blood circulation, brain vasculature epithelium, brain vasculature (all 26) expand
DISEASE ASSOCIATED WITH ilk HUMAN ORTHOLOG No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process heart contraction (more)
Cellular Component Z disc (more)
Molecular Function protein kinase activity (more)
GO Terms (all 17)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000719 (1)
  • InterPro:IPR001245 (1)
  • InterPro:IPR002110 (1)
  • InterPro:IPR011009 (1)
  • InterPro:IPR020683 (1)
  • PROSITE:PS50011 (1)
  • PROSITE:PS50088 (1)
  • PROSITE:PS50297 (1)
  • Pfam:PF07714 (1)
  • Pfam:PF12796 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA ilk-001 (1) 3200
    ncRNA ilk-002 (1) 803
    GENE PRODUCT DESCRIPTION
    ANTIBODIES
    Ab1-ilk (1), Ab2-ilk (1)
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ilk No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    ilk Contained in: [BAC] CH211-287A12 (1) (order this)
    ilk Encodes: [cDNA] MGC:65842 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_200571 (1) 3170 bp
    Genomic GenBank:AL928852 (1) 157466 bp
    Select Tool
    Polypeptide UniProtKB:Q6PHD6 (1) 452 aa
    Sequence Clusters UniGene:77678 (1)
    Sequence Information (all 8)
    OTHER ilk GENE PAGES
  • Gene:393543 (1)
  • VEGA:OTTDARG00000019524 (1)
  • Ensembl(Zv9):ENSDARG00000056964 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish ilk 10  
    Human ILK 11 (11p15.4)
  • OMIM:602366
  • Gene:3611
  • Mouse Ilk 7 ( 55.97 cM)
  • MGI:1195267
  • Gene:16202
  • Orthology Details
    CITATIONS (33)