ZFIN ID: ZDB-GENE-040426-1435
Gene Name: integrin-linked kinase
Gene Symbol: ilk
Previous Names: loc, lost-contact, main squeeze, msq, zgc:65842, zilk (1)
Location: Chr: 10 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 12 figures from 8 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:65842]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
  blood vessel endothelial cell, brain, cardiac muscle cell Z disc, heart (all 15) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS 
Allele Type Mutagen Suppliers
hu801 Point Mutation
m347 Point Mutation ENU
Targeting reagents: MO1-ilk (2), MO2-ilk (2), MO3-ilk (1), MO4-ilk (1)
PHENOTYPE
Data: 15 figures from 9 publications
Observed in: blood, blood circulation, brain vasculature epithelium, brain vasculature (all 26) expand
DISEASE ASSOCIATED WITH ilk HUMAN ORTHOLOG No data available
GENE ONTOLOGY 
Ontology GO Term
Biological Process heart contraction (more)
Cellular Component Z disc (more)
Molecular Function protein kinase activity (more)
GO Terms (all 17)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000719 (1)
  • InterPro:IPR001245 (1)
  • InterPro:IPR002110 (1)
  • InterPro:IPR011009 (1)
  • InterPro:IPR020683 (1)
  • PROSITE:PS50011 (1)
  • PROSITE:PS50088 (1)
  • PROSITE:PS50297 (1)
  • Pfam:PF07714 (1)
  • Pfam:PF12796 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA ilk-001 (1) 3200
    ncRNA ilk-002 (1) 803
    GENE PRODUCT DESCRIPTION
    ANTIBODIES 
    Ab1-ilk (1), Ab2-ilk (1)
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ilk No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS 
    ilkContained in: [BAC] CH211-287A12 (1) (order this)
    ilkEncodes: [cDNA] MGC:65842 (1) (order this)
    SEQUENCE INFORMATION 
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_200571 (1) 3170bp
    Genomic GenBank:AL928852 (1) 157466bp
    Select Tool
    Polypeptide UniProtKB:Q6PHD6 (1) 452aa
    Sequence Clusters UniGene:77678 (1)
    Sequence Information (all 8)
    OTHER ilk GENE PAGES 
  • Gene:393543 (1)
  • VEGA:OTTDARG00000019524 (1)
  • Ensembl(GRCz10):ENSDARG00000056964 (1)
  • ORTHOLOGY for ilk (Chr: 10) 
    Species Symbol Chromosome Accession # Evidence
    Human ILK 11
  • Gene:3611
  • OMIM:602366
  • HGNC:6040
  • Amino acid sequence comparison (4)
    Conserved genome location (synteny) (1)
    Mouse Ilk 7
  • MGI:1195267
  • Gene:16202
  • Amino acid sequence comparison (2)
    Conserved genome location (synteny) (1)
    Download Curated Orthology
    CITATIONS (33)