Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-040426-1435
Gene Name: integrin-linked kinase
Gene Symbol: ilk
Previous Names: zilk (1), loc, lost-contact, main squeeze, msq, zgc:65842
Location: Chr: 10   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 9 figures from 6 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:65842]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
  blood vessel endothelial cell, brain, cardiac muscle cell Z disc, heart (all 12) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 7 genotypes
Alleles: hu801, m347
Knockdown reagents: MO1-ilk (2), MO2-ilk (2), MO3-ilk (1), MO4-ilk (1)
PHENOTYPE
Data: 14 figures from 8 publications
Observed in: blood, blood circulation, brain vasculature epithelium, brain vasculature (all 26) expand
GENE ONTOLOGY
Ontology GO Term
Biological Process heart contraction (more)
Cellular Component Z disc (more)
Molecular Function protein kinase activity (more)
GO Terms (all 19)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000719 (1)
  • InterPro:IPR001245 (1)
  • InterPro:IPR002110 (1)
  • InterPro:IPR011009 (1)
  • InterPro:IPR016253 (1)
  • InterPro:IPR020683 (1)
  • PROSITE:PS50011 (1)
  • PROSITE:PS50088 (1)
  • PROSITE:PS50297 (1)
  • Pfam:PF07714 (1)
  • Pfam:PF12796 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA ilk-001 (1) 3200
    ncRNA ilk-002 (1) 803
    GENE PRODUCT DESCRIPTION
    ANTIBODIES
    Ab1-ilk (1)
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ilk No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    ilk Contained in: [BAC] CH211-287A12 (1) (order this)
    ilk Encodes: [cDNA] MGC:65842 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_200571 (1) 3170 bp
    Genomic GenBank:AL928852 (1) 157466 bp
    Select Tool
    Polypeptide UniProtKB:Q6PHD6 (1) 452 aa
    Sequence Clusters UniGene:77678 (1)
    Sequence Information (all 8)
    OTHER ilk GENE PAGES
  • Gene:393543 (1)
  • VEGA:OTTDARG00000019524 (1)
  • Ensembl(Zv9):ENSDARG00000056964 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish ilk 10  
    Human ILK 11 (11p15.4)
  • OMIM:602366
  • Gene:3611
  • Mouse Ilk 7 ( 55.97 cM)
  • MGI:1195267
  • Gene:16202
  • Orthology Details
    CITATIONS (30)