Gene

ilk

ID
ZDB-GENE-040426-1435
Name
integrin-linked kinase
Symbol
ilk Nomenclature History
Previous Names
  • loc
  • lost-contact
  • main squeeze
  • msq
  • zgc:65842
  • zilk (1)
Type
protein_coding_gene
Location
Chr: 10 Mapping Details/Browsers
Description
Exhibits protein kinase activity. Involved in several processes, including circulatory system development; muscle attachment; and tendon development. Localizes to Z disc and sarcolemma. Predicted to colocalize with stress fiber. Is expressed in brain; cardiovascular system; muscle; myoblast; and somite. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human ILK (integrin linked kinase).
Genome Resources
Note
None
Expression
All Expression Data
12 figures from 8 publications
Cross-Species Comparison
High Throughput Data
No data available
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
20 figures from 11 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ilk Human Ortholog
No data available
Associated With ilk Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000719 Protein kinase domain
Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain IPR020683 Ankyrin repeat-containing domain
Domain IPR035692 Integrin-linked protein kinase, pseudokinase domain
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR036770 Ankyrin repeat-containing domain superfamily
Repeat IPR002110 Ankyrin repeat
Domain Details Per Protein
Protein Length Ankyrin repeat Ankyrin repeat-containing domain Ankyrin repeat-containing domain superfamily Integrin-linked protein kinase, pseudokinase domain Protein kinase domain Protein kinase-like domain superfamily Serine-threonine/tyrosine-protein kinase, catalytic domain
UniProtKB:Q6PHD6 452
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-ilk monoclonal IgG2b Mouse
  • IHC
  • WB
Millipore
3
Ab2-ilk polyclonal IgG Rabbit
  • IHC
GeneTex
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations