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ZIRC
ZFIN ID: ZDB-GENE-040426-1435
Gene Name: integrin-linked kinase
Gene Symbol: ilk    Nomenclature History

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Previous Names: loc, lost-contact, main squeeze, msq, zgc:65842, zilk (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Exhibits protein kinase activity. Involved in several processes, including circulatory system development; muscle attachment; and tendon development. Localizes to the Z disc and sarcolemma. Predicted to colocalize with the stress fiber. Human ortholog(s) of this gene implicated in pancreatic cancer. Is expressed in brain; cardiovascular system; muscle; myoblast; and somite. Orthologous to human ILK (integrin linked kinase).
Genome Resources: Alliance (1),  Gene:393543 (1),  Ensembl(GRCz11):ENSDARG00000056964 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu801 Point Mutation Exon 10 Premature Stop
m347 Point Mutation Unknown Missense ENU
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-ilk N/A 6
MO2-ilk N/A 5
MO3-ilk N/A 1
MO4-ilk N/A 1
DISEASE ASSOCIATED WITH ilk HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH ilk VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process endothelial cell development (more)
Cellular Component cytoplasm (more)
Molecular Function protein kinase activity (more)
GO Terms (all 24)
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA ilk-201 (1)    Ensembl 3200
ncRNA ilk-002 (1)    Ensembl 803
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab1-ilk monoclonal IgG2b Mouse IHC, WB Millipore
3
Ab2-ilk polyclonal IgG Rabbit IHC GeneTex
1
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM ilk No data available
MARKER RELATIONSHIPS
ilk Contained in: [BAC] CH211-287A12 (1) (order this)
ilk Encodes: [cDNA] MGC:65842 (1) (order this)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_200571 (1) 3170 bp
Genomic GenBank:AL928852 (1) 157466 bp
Select Tool
Polypeptide UniProtKB:Q6PHD6 (1) 452 aa
Sequence Clusters UniGene:77678 (1)
Sequence Information (all 9)
ORTHOLOGY for ilk ( Chr: 10 )
CITATIONS (43)