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ZIRC
ZFIN ID: ZDB-GENE-040426-1435
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Gene Name: integrin-linked kinase
Gene Symbol: ilk    Nomenclature History

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Previous Names: loc, lost-contact, main squeeze, msq, zgc:65842, zilk (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Exhibits protein kinase activity. Involved in several processes, including circulatory system development; muscle attachment; and tendon development. Localizes to the Z disc and sarcolemma. Predicted to colocalize with the stress fiber. Human ortholog(s) of this gene implicated in pancreatic cancer. Is expressed in brain; cardiovascular system; muscle; myoblast; and somite. Orthologous to human ILK (integrin linked kinase).
Genome Resources: Alliance (1),  Gene:393543 (1),  Ensembl(GRCz11):ENSDARG00000056964 (2)
GENE EXPRESSION
All Expression Data: 12 figures from 8 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:65842]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu801 Point Mutation Exon 10 Premature Stop
m347 Point Mutation Unknown Missense ENU
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-ilk N/A 6
MO2-ilk N/A 5
MO3-ilk N/A 1
MO4-ilk N/A 1
PHENOTYPE
Data: 19 figures from 10 publications
Observed in:
DISEASE ASSOCIATED WITH ilk HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH ilk VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process endothelial cell development (more)
Cellular Component cytoplasm (more)
Molecular Function protein kinase activity (more)
GO Terms (all 24)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000719 (1)
  • InterPro:IPR001245 (1)
  • InterPro:IPR002110 (1)
  • InterPro:IPR011009 (1)
  • InterPro:IPR020683 (1)
  • InterPro:IPR035692 (1)
  • InterPro:IPR036770 (1)
  • PROSITE:PS50011 (1)
  • PROSITE:PS50088 (1)
  • PROSITE:PS50297 (1)
  • Pfam:PF07714 (1)
  • Pfam:PF12796 (1)
    • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ilk-201 (1)    Ensembl 3200
    Select Tool
    ncRNA ilk-002 (1)    Ensembl 803
    Select Tool
    Browsers: UCSC,  NCBI,  Ensembl,  ZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-ilk monoclonal IgG2b Mouse IHC, WB Millipore
    		3
    Ab2-ilk polyclonal IgG Rabbit IHC GeneTex
    		1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ilk No data available
    MARKER RELATIONSHIPS
    ilk Contained in: [BAC] CH211-287A12 (1) (order this)
    ilk Encodes: [cDNA] MGC:65842 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_200571 (1) 3170 bp
    Select Tool
    Genomic GenBank:AL928852 (1) 157466 bp
    Select Tool
    Polypeptide UniProtKB:Q6PHD6 (1) 452 aa
    Select Tool
    Sequence Clusters UniGene:77678 (1)
    Sequence Information (all 9)
    ORTHOLOGY for ilk ( Chr: 10 )
    CITATIONS (43)