Gene
pdgfaa
- ID
- ZDB-GENE-030918-2
- Name
- platelet-derived growth factor alpha polypeptide a
- Symbol
- pdgfaa Nomenclature History
- Previous Names
-
- pdgfa
- Platelet-derived growth factor A (1)
- zgc:100777
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to have platelet-derived growth factor receptor binding activity. Involved in cardiac muscle progenitor cell migration to the midline involved in heart field formation. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in malignant glioma. Is expressed in several structures, including anterior neural keel; chordo neural hinge; diencephalon; endoderm; and head. Orthologous to human PDGFA (platelet derived growth factor subunit A).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 24 figures from 17 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu754 (15 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-pdgfaa | (2) | |
MO1-pdgfaa | N/A | (2) |
MO2-pdgfaa | N/A | Espina et al., 2018 |
MO3-pdgfaa | N/A | Owen et al., 2022 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Length | Cystine-knot cytokine | PDGF/VEGF domain | Platelet-derived growth factor, conserved site | Platelet-derived growth factor, N-terminal |
---|---|---|---|---|---|
UniProtKB:A5PMP7
|
194 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
pdgfaa-202
(1)
|
Ensembl | 1,464 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
---|---|---|---|---|---|
Tg(hsp70l:pdgfaa-2A-mCherry,cryaa:CFP) |
| 1 | Bloomekatz et al., 2017 |
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Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-140F21 | ZFIN Curated Data | |
Contained in | BAC | DKEY-30O19 | ZFIN Curated Data | |
Encodes | EST | eu754 | Thisse et al., 2005 | |
Encodes | cDNA | MGC:100777 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_194426 (1) | 1581 nt | ||
Genomic | GenBank:BX649330 (1) | 163964 nt | ||
Polypeptide | UniProtKB:A5PMP7 (1) | 194 aa |
- Mao, A., Li, Z., Ning, G., Zhou, Z., Wei, C., Li, J., He, X., Wang, Q. (2023) Sclerotome-derived PDGF signaling functions as a niche cue responsible for primitive erythropoiesis. Development (Cambridge, England). 150(22):
- Murayama, E., Vivier, C., Schmidt, A., Herbomel, P. (2023) Alcam-a and Pdgfr-α are essential for the development of sclerotome-derived stromal cells that support hematopoiesis. Nature communications. 14:11711171
- Zhao, Y., Wang, H., He, T., Ma, B., Chen, G., Tzeng, C. (2023) Knockdown of Yap attenuates TAA-induced hepatic fibrosis by interaction with hedgehog signals. Journal of cell communication and signaling. 17(4):1335-1354
- Owen, N., Toms, M., Young, R.M., Eintracht, J., Sarkar, H., Brooks, B.P., Moosajee, M., Genomics England Research Consortium (2022) Identification of 4 novel human ocular coloboma genes ANK3, BMPR1B, PDGFRA, and CDH4 through evolutionary conserved vertebrate gene analysis. Genetics in medicine : official journal of the American College of Medical Genetics. 24(5):1073-1084
- Das, T., Soren, K., Yerasi, M., Kamle, A., Kumar, A., Chakravarty, S. (2020) Molecular Basis of Sex Difference in Neuroprotection induced by Hypoxia Preconditioning in Zebrafish. Molecular neurobiology. 57(12):5177-5192
- Lee, Y.H., Kawakami, K., HuangFu, W.C., Liu, I.H. (2020) Chondroitin sulfate proteoglycan 4 regulates zebrafish body axis organization via Wnt/planar cell polarity pathway. PLoS One. 15:e0230943
- Liu, L., Yu, F., Li, L., Zhou, L., Zhou, T., Xu, Y., Lin, K., Fang, B., Xia, L. (2020) Bone marrow stromal cells stimulated by strontium-substituted calcium silicate ceramics: release of exosomal miR-146a regulates osteogenesis and angiogenesis. Acta biomaterialia. 119:444-457
- Saito, Y., Yamaguchi, A., Nakamura, S., Okuyoshi, H., Shimazawa, M., Hara, H. (2020) Contribution of platelet-derived growth factor signaling to retina regeneration in zebrafish. Neuroscience letters. 727:134930
- Tsata, V., Möllmert, S., Schweitzer, C., Kolb, J., Möckel, C., Böhm, B., Rosso, G., Lange, C., Lesche, M., Hammer, J., Kesavan, G., Beis, D., Guck, J., Brand, M., Wehner, D. (2020) A switch in pdgfrb+ cell-derived ECM composition prevents inhibitory scarring and promotes axon regeneration in the zebrafish spinal cord. Developmental Cell. 56(4):509-524.e9
- Li, L., Ning, G., Yang, S., Yan, Y., Cao, Y., Wang, Q. (2019) BMP signaling is required for nkx2.3-positive pharyngeal pouch progenitor specification in zebrafish. PLoS Genetics. 15:e1007996
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