Gene

pdgfaa

ID
ZDB-GENE-030918-2
Name
platelet-derived growth factor alpha polypeptide a
Symbol
pdgfaa Nomenclature History
Previous Names
  • pdgfa
  • Platelet-derived growth factor A (1)
  • zgc:100777
Type
protein_coding_gene
Location
Chr: 22 Mapping Details/Browsers
Description
Predicted to have platelet-derived growth factor receptor binding activity. Involved in cardiac muscle progenitor cell migration to the midline involved in heart field formation. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in malignant glioma. Is expressed in several structures, including anterior neural keel; chordo neural hinge; diencephalon; endoderm; and head. Orthologous to human PDGFA (platelet derived growth factor subunit A).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
24 figures from 17 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
ioz23Allele with one delinsUnknownUnknownCRISPR
sa37527Allele with one point mutationUnknownPremature StopENU
sa43858Allele with one point mutationUnknownPremature StopENU
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
CRISPR1-pdgfaa (2)
MO1-pdgfaaN/A (2)
MO2-pdgfaaN/AEspina et al., 2018
MO3-pdgfaaN/AOwen et al., 2022
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Human Disease
Associated With pdgfaa Human Ortholog
No data available
Associated With pdgfaa Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR023581 Platelet-derived growth factor, conserved site
Domain IPR000072 PDGF/VEGF domain
Domain IPR006782 Platelet-derived growth factor, N-terminal
Homologous_superfamily IPR029034 Cystine-knot cytokine
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Domain Details Per Protein
Protein Length Cystine-knot cytokine PDGF/VEGF domain Platelet-derived growth factor, conserved site Platelet-derived growth factor, N-terminal
UniProtKB:A5PMP7 194
1 - 1 of 1
Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 22
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA pdgfaa-202 (1) Ensembl 1,464 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Construct Regulatory Region Coding Sequence Species Tg Lines Citations
Tg(hsp70l:pdgfaa-2A-mCherry,cryaa:CFP)
  • Danio rerio
1Bloomekatz et al., 2017
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Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-140F21ZFIN Curated Data
Contained inBACDKEY-30O19ZFIN Curated Data
EncodesESTeu754Thisse et al., 2005
EncodescDNAMGC:100777ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanPDGFA7
Amino acid sequence comparison (2)
MousePdgfa5
Amino acid sequence comparison (1)
Citations
1 - 10 of 35
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