Gene
hsd3b2
- ID
- ZDB-GENE-030828-2
- Name
- hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
- Symbol
- hsd3b2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Enables 3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity. Acts upstream of or within embryonic morphogenesis and steroid biosynthetic process. Is expressed in brain; gonad; head kidney; and yolk syncytial layer. Human ortholog(s) of this gene implicated in hypertension and hypospadias. Orthologous to human HSD3B1 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1) and HSD3B2 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2).
- Genome Resources
- Note
-
The name of this gene was changed because another gene was found to have very strong orthology with human HSD3B1. The current name of this gene, hsd3b2, reflects this gene's relationship to other hsd3b2 genes in fish and not its orthology to human HSD3B2
- Comparative Information
-
- All Expression Data
- 24 figures from 16 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb723 (5 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Lin et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la021391Tg | Transgenic insertion | Unknown | Unknown | DNA |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | 3-beta hydroxysteroid dehydrogenase/isomerase | Bifunctional lipid A modification and metabolic enzymes | NAD(P)-binding domain superfamily |
|---|---|---|---|---|---|
| UniProtKB:Q7ZZC3 | InterPro | 374 | |||
| UniProtKB:A0AB32TDU5 | InterPro | 283 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
hsd3b2-201
(1)
|
Ensembl | 1,369 nt | ||
| mRNA |
hsd3b2-202
(1)
|
Ensembl | 1,258 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-181I3 | ZFIN Curated Data | |
| Encodes | EST | cb723 | Thisse et al., 2001 | |
| Encodes | cDNA | MGC:111865 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:122972 | ||
| Encodes | cDNA | MGC:191949 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_212797 (1) | 1389 nt | ||
| Genomic | GenBank:BX248418 (1) | 152757 nt | ||
| Polypeptide | UniProtKB:Q7ZZC3 (1) | 374 aa |
No data available
- Yu, Y., Tanaka, S., Wong, T.T., Zohar, Y., Zmora, N. (2024) Loss of function of Vasoactive-intestinal peptide alters sex ratio and reduces male reproductive fitness in zebrafish. Endocrinology. 165(8):
- Zhang, F., Tang, C., Wang, J., Lin, T., Ge, W., He, C., Yang, C., Zuo, Z. (2024) Letrozole induced a polycystic ovary syndrome model in zebrafish by interfering with the hypothalamic-pituitary-gonadal axis. Environmental pollution (Barking, Essex : 1987). 347:123723
- Liao, X., Tao, B., Zhang, X., Chen, L., Chen, J., Song, Y., Hu, W. (2023) Loss of gdnfa disrupts spermiogenesis and male courtship behavior in zebrafish. Molecular and Cellular Endocrinology. 576:112010
- Chen, X., Zheng, J., Zhang, J., Duan, M., Xu, H., Zhao, W., Yang, Y., Wang, C., Xu, Y. (2022) Exposure to difenoconazole induces reproductive toxicity in zebrafish by interfering with gamete maturation and reproductive behavior. The Science of the total environment. 838(Pt 1):155610
- Duan, M., Guo, X., Chen, X., Guo, M., Xu, H., Hao, L., Wang, C., Yang, Y. (2022) Life Cycle Exposure to Cyhalofop-Butyl Induced Reproductive Toxicity in Zebrafish. Toxics. 10(9)
- Liu, Y., Kassack, M.E., McFaul, M.E., Christensen, L.N., Siebert, S., Wyatt, S.R., Kamei, C.N., Horst, S., Arroyo, N., Drummond, I.A., Juliano, C.E., Draper, B.W. (2022) Single-cell transcriptome reveals insights into the development and function of the zebrafish ovary. eLIFE. 11:
- Rodrigues, M.S., Tovo-Neto, A., Rosa, I.F., Doretto, L.B., Fallah, H.P., Habibi, H.R., Nóbrega, R.H. (2022) Thyroid Hormones Deficiency Impairs Male Germ Cell Development: A Cross Talk Between Hypothalamic-Pituitary-Thyroid, and-Gonadal Axes in Zebrafish. Frontiers in cell and developmental biology. 10:865948
- Zou, T., Liang, Y.Q., Liao, X., Chen, X.F., Wang, T., Song, Y., Lin, Z.C., Qi, Z., Chen, Z.F., Cai, Z. (2021) Metabolomics reveals the reproductive abnormality in female zebrafish exposed to environmentally relevant levels of climbazole. Environmental pollution (Barking, Essex : 1987). 275:116665
- Bhuiyan, M.N.H., Kang, H., Choi, J., Lim, S., Kho, Y., Choi, K. (2020) Effects of 3,4-dichloroaniline (3,4-DCA) and 4,4'-methylenedianiline (4,4'-MDA) on sex hormone regulation and reproduction of adult zebrafish (Danio rerio). Chemosphere. 269:128768
- Chen, H., Chen, K., Qiu, X., Xu, H., Mao, G., Zhao, T., Feng, W., Okeke, E.S., Wu, X., Yang, L. (2020) The reproductive toxicity and potential mechanisms of combined exposure to dibutyl phthalate and diisobutyl phthalate in male zebrafish (Danio rerio). Chemosphere. 258:127238
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