Gene

mdga2a

ID

ZDB-GENE-030616-360

Name

MAM domain containing glycosylphosphatidylinositol anchor 2a

Symbol

mdga2a Nomenclature History

Previous Names

mamdc1
si:dz209d10.1

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Description

Involved in facial nerve formation; regulation of motor neuron migration; and trigeminal motor nucleus development. Predicted to localize to membrane. Is expressed in several structures, including brainstem; cranial nerve; muscle; pharyngeal musculature; and posterior lateral line. Orthologous to human MDGA2 (MAM domain containing glycosylphosphatidylinositol anchor 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from Ingold et al., 2015

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from Ingold et al., 2015
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mdga2a Human Ortholog

No data available

Associated With mdga2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000998	MAM domain
Domain	IPR003598	Immunoglobulin subtype 2
Domain	IPR003599	Immunoglobulin domain subtype
Domain	IPR007110	Immunoglobulin-like domain
Domain	IPR013098	Immunoglobulin I-set
Family	IPR050958	Cell Adhesion and Cytoskeletal Organization
Homologous_superfamily	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR036116	Fibronectin type III superfamily
Homologous_superfamily	IPR036179	Immunoglobulin-like domain superfamily

Domain Details Per Protein

Protein	Length	Cell Adhesion and Cytoskeletal Organization	Concanavalin A-like lectin/glucanase domain superfamily	Fibronectin type III superfamily	Immunoglobulin domain subtype	Immunoglobulin I-set	Immunoglobulin-like domain	Immunoglobulin-like domain superfamily	Immunoglobulin-like fold	Immunoglobulin subtype 2	MAM domain
UniProtKB:A0A8M9Q2L0 InterPro	958
UniProtKB:A0A8M6YTC4 InterPro	957
UniProtKB:A0A8M9Q6Q8 InterPro	963
UniProtKB:A0A8M9PVK8 InterPro	964

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	mdga2a-201 (1) Ensembl	Ensembl	4,138 nt	Select Tool ZFIN BLAST
mRNA	mdga2a-202 (1) Ensembl	Ensembl	585 nt	Select Tool ZFIN BLAST
mRNA	mdga2a-203 (1) Ensembl	Ensembl	2,838 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-mdga2a	polyclonal	mdga2a		Rabbit	IHC		1

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations