Gene
myo6b
- ID
- ZDB-GENE-030318-3
- Name
- myosin VIb
- Symbol
- myo6b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable actin filament binding activity and microfilament motor activity. Acts upstream of or within detection of mechanical stimulus involved in sensory perception; neurogenesis; and retina development in camera-type eye. Predicted to be located in clathrin-coated pit; microvillus; and ruffle membrane. Predicted to be part of myosin complex. Predicted to be active in several cellular components, including actin cytoskeleton; endocytic vesicle; and ruffle. Is expressed in anterior macula and neuromast hair cell. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 22; autosomal recessive nonsyndromic deafness 37; ovarian cancer; and sensorineural hearing loss. Orthologous to human MYO6 (myosin VI).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ru920 | Allele with one point mutation | Exon 5 | Premature Stop | ENU | |
| sa2929 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa18082 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa42976 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| t2460 | Allele with one point mutation | Unknown | Unknown | not specified | |
| tn011 | Allele with one point mutation | Unknown | Unknown | not specified | |
| tn3137 | Allele with one point mutation | Unknown | Unknown | not specified | |
| tn3216 | Allele with one point mutation | Unknown | Unknown | not specified |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-myo6b | Charlton-Perkins et al., 2019 | |
| CRISPR2-myo6b | Charlton-Perkins et al., 2019 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant nonsyndromic deafness 22 | Alliance | Deafness, autosomal dominant 22 | 606346 |
| autosomal dominant nonsyndromic deafness 22 | Alliance | Deafness, autosomal dominant 22, with hypertrophic cardiomyopathy | 606346 |
| autosomal recessive nonsyndromic deafness 37 | Alliance | Deafness, autosomal recessive 37 | 607821 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Class VI myosin, motor domain | Kinesin motor domain superfamily | Myosin head, motor domain-like | Myosin, N-terminal, SH3-like | Myosin S1 fragment, N-terminal | Myosin VI, cargo binding domain | Myosin VI, lever arm | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M1N1X8 | InterPro | 1267 | ||||||||
| UniProtKB:F1R4R9 | InterPro | 1255 | ||||||||
| UniProtKB:A0A8M9P042 | InterPro | 1267 | ||||||||
| UniProtKB:Q68RJ3 | InterPro | 1267 | ||||||||
| UniProtKB:A0A8M9P8V8 | InterPro | 1264 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg2(-6myo6b:pcdh15a-EGFP) |
|
| 1 | (3) | |
| Tg2(myo6b:EGFP) |
|
| 1 | Suli et al., 2014 | |
| Tg3(-6myo6b:pcdh15a-EGFP) |
|
| 1 | Maeda et al., 2017 | |
| Tg4(-6myo6b:pcdh15a-EGFP) |
|
| 1 | Maeda et al., 2017 | |
| Tg5(-6myo6b:pcdh15a-EGFP) |
|
| 1 | Maeda et al., 2017 | |
| Tg(-6.5myo6b:ctbp2l-EGFP) |
|
| 1 | (7) | |
| Tg(-6.5myo6b:HA-Tgo.Uprt-2A-mCherry) |
|
| 1 | (2) | |
| Tg(-6.5myo6b:nsfa-EGFP) |
|
| 2 | (3) | |
| Tg6(-6myo6b:pcdh15a-EGFP) |
|
| 1 | Maeda et al., 2017 | |
| Tg(-6myo6b:ctbp2a-mCherry) |
|
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-77G5 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-264C3 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001004110 (1) | 3917 nt | ||
| Genomic | GenBank:BX571720 (1) | 227706 nt | ||
| Polypeptide | UniProtKB:A0A8M1N1X8 (1) | 1267 aa |
- Jędrychowska, J., Vardanyan, V., Wieczor, M., Marciniak, A., Czub, J., Amini, R., Jain, R., Shen, H., Choi, H., Kuznicki, J., Korzh, V. (2024) Mutant analysis of Kcng4b reveals how the different functional states of the voltage-gated potassium channel regulate ear development. Developmental Biology. 513:50-62
- McQuate, A., Knecht, S., Raible, D.W. (2023) Activity regulates a cell type-specific mitochondrial phenotype in zebrafish lateral line hair cells. eLIFE. 12:
- Shi, T., Beaulieu, M.O., Saunders, L.M., Fabian, P., Trapnell, C., Segil, N., Crump, J.G., Raible, D.W. (2023) Single-cell transcriptomic profiling of the zebrafish inner ear reveals molecularly distinct hair cell and supporting cell subtypes. eLIFE. 12:
- Alkowari, M., Espino-Guarch, M., Daas, S., Abdelrahman, D., Hasan, W., Krishnamoorthy, N., Sathappan, A., Sheehan, P., Panhuys, N.V., The Qatar Genome Program Research Consortium, ., Estivill, X. (2022) Functional Characterization of the MYO6 Variant p.E60Q in Non-Syndromic Hearing Loss Patients. International Journal of Molecular Sciences. 23(6):
- Gao, G., Guo, S., Zhang, Q., Zhang, H., Zhang, C., Peng, G. (2022) Kiaa1024L/Minar2 is essential for hearing by regulating cholesterol distribution in hair bundles. eLIFE. 11:
- Jimenez, E., Slevin, C.C., Song, W., Chen, Z., Frederickson, S.C., Gildea, D., Wu, W., Elkahloun, A.G., Ovcharenko, I., Burgess, S.M. (2022) A regulatory network of Sox and Six transcription factors initiate a cell fate transformation during hearing regeneration in adult zebrafish. Cell genomics. 2(9):
- Tanimoto, M., Watakabe, I., Higashijima, S.I. (2022) Tiltable objective microscope visualizes selectivity for head motion direction and dynamics in zebrafish vestibular system. Nature communications. 13:76227622
- Zhang, Q., Kindt, K.S. (2022) Using Light-Sheet Microscopy to Study Spontaneous Activity in the Developing Lateral-Line System. Frontiers in cell and developmental biology. 10:819612
- Jimenez, E., Slevin, C.C., Colón-Cruz, L., Burgess, S.M. (2021) Vestibular and Auditory Hair Cell Regeneration Following Targeted Ablation of Hair Cells With Diphtheria Toxin in Zebrafish. Frontiers in Cellular Neuroscience. 15:721950
- Li, X.D., Tu, H.W., Hu, K.Q., Liu, Y.G., Mao, L.N., Wang, F.Y., Qu, H.Y., Chen, Q. (2021) Effects of Toluene on the Development of the Inner Ear and Lateral Line Sensory System of Zebrafish. Biomedical and environmental sciences : BES. 34:110-118
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