Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-030219-92
Gene Name: zic family member 2 (odd-paired homolog, Drosophila) b
Gene Symbol: zic2b
Previous Names: zic2.2 (1), zic2l, hm:zeh0655, id:ibd5017
Location: Chr: 1   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 11 figures from 8 publications
Directly Submitted Expression Data: 4 figures (5 images) from Kudoh et al., 2001 [ibd5017]
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Pharyngula:Prim-5 (24.0h-30.0h)
  anterior neural keel lateral region, anterior neural rod lateral region, cranial neural crest, epiblast (all 17) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Alleles: la028121Tg, la028122Tg
Knockdown reagents: MO1-zic2b (1), MO2-zic2b (1)
PHENOTYPE
Data: 5 figures from Teslaa et al., 2013
Observed in: cranial neural crest, embryonic viscerocranium morphogenesis, forebrain development, melanoblast (all 16) expand

Phenotype of Human Orthologue OMIM Phenotype ID
Holoprosencephaly-5 609637
GENE ONTOLOGY
Ontology GO Term
Biological Process embryonic viscerocranium morphogenesis (more)
Molecular Function metal ion binding (more)
GO Terms (all 4)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR007087 (1)
  • InterPro:IPR013087 (1)
  • InterPro:IPR015880 (1)
  • PROSITE:PS00028 (1)
  • PROSITE:PS50157 (1)
  • Pfam:PF00096 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA zic2b-001 (1) 2248
    ncRNA zic2b-002 (1) 693
    GENE PRODUCT DESCRIPTION No description available
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM zic2b No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    zic2b Contained in: [BAC] DKEY-256M19 (1)
    zic2b Contains: [SNP] rs3727533 (1), rs3727534 (1)
    zic2b Encodes: [EST] ibd5017 (order this), zeh0655
    [cDNA] MGC:110428 (1) (order this), MGC:198352 (1) (order this), MGC:198356 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001001820 (1) 2239 bp
    Genomic GenBank:BX088652 (1) 161341 bp
    Select Tool
    Polypeptide UniProtKB:Q9DE40 (1) 427 aa
    Sequence Clusters UniGene:76511 (1)
    Sequence Information (all 23)
    OTHER zic2b GENE PAGES
  • Gene:570746 (1)
  • VEGA:OTTDARG00000027069 (1)
  • Ensembl(Zv9):ENSDARG00000037178 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish zic2b 1  
    Human ZIC2 13 (13q32)
  • OMIM:603073
  • Gene:7546
  • Mouse Zic2 14 ( 65.97 cM)
  • MGI:106679
  • Gene:22772
  • Orthology Details
    CITATIONS (31)