Gene
slbp
- ID
- ZDB-GENE-030131-9686
- Name
- stem-loop histone mRNA binding protein
- Symbol
- slbp Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable histone pre-mRNA stem-loop binding activity and mRNA binding activity. Acts upstream of or within nervous system development and neural retina development. Predicted to be part of histone pre-mRNA 3'end processing complex. Predicted to be active in cytoplasm. Is expressed in several structures, including digestive system; immature eye; musculature system; nervous system; and pleuroperitoneal region. Orthologous to human SLBP (stem-loop histone mRNA binding protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb157 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- 17 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ihb494 | Allele with one deletion | Exon 6 | Unknown | CRISPR | |
| la012500Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| rw440 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| ty77e | Allele with one point mutation | Exon 5 | Premature Stop | ENU | |
| zf2221 | Allele with one deletion | Exon 6 | Frameshift, Premature Stop | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-slbp | Zebrafish Nomenclature Committee | |
| MO1-slbp | N/A | Turner et al., 2019 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Histone RNA hairpin-binding protein, RNA-binding domain | Histone RNA stem-loop-binding protein SLBP1/SLBP2 | SLBP, RNA-binding domain superfamily |
|---|---|---|---|---|---|
| UniProtKB:A0A8M1P3D7 | InterPro | 271 | |||
| UniProtKB:Q7SXI8 | InterPro PDB | 290 | |||
| UniProtKB:A0A8M1NZD7 | InterPro | 236 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-102M7 | ZFIN Curated Data | |
| Encodes | EST | cb157 | Thisse et al., 2001 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001256193 (1) | 1325 nt | ||
| Genomic | GenBank:BX323828 (1) | 206011 nt | ||
| Polypeptide | UniProtKB:Q7SXI8 (1) | 290 aa |
- Saraswathy, V.M., Zhou, L., McAdow, A.R., Burris, B., Dogra, D., Reischauer, S., Mokalled, M.H. (2022) Myostatin is a negative regulator of adult neurogenesis after spinal cord injury in zebrafish. Cell Reports. 41:111705111705
- Cerveny, K.L., Bronstein, H., Hagen, O., Lamb, D.B., Martin, G., Tower, I., Van Duzer, A., Welch, E., Varga, M. (2021) Mutations linked to loss of cell cycle control can render cells responsive to local differentiation cues. microPublication. Biology. 2021:
- Ranawat, N., Masai, I. (2021) Mechanisms underlying microglial colonization of developing neural retina in zebrafish. eLIFE. 10:
- Abrams, E.W., Fuentes, R., Marlow, F.L., Kobayashi, M., Zhang, H., Lu, S., Kapp, L., Joseph, S.R., Kugath, A., Gupta, T., Lemon, V., Runke, G., Amodeo, A.A., Vastenhouw, N.L., Mullins, M.C. (2020) Molecular genetics of maternally-controlled cell divisions. PLoS Genetics. 16:e1008652
- Turner, K.J., Hoyle, J., Valdivia, L.E., Cerveny, K.L., Hart, W., Mangoli, M., Geisler, R., Rees, M., Houart, C., Poole, R.J., Wilson, S.W., Gestri, G. (2019) Abrogation of Stem Loop Binding Protein (Slbp) function leads to a failure of cells to transition from proliferation to differentiation, retinal coloboma and midline axon guidance deficits. PLoS One. 14:e0211073
- He, W.X., Wu, M., Liu, Z., Li, Z., Wang, Y., Zhou, J., Yu, P., Zhang, X.J., Zhou, L., Gui, J.F. (2018) Oocyte-specific maternal Slbp2 is required for replication-dependent histone storage and early nuclear cleavage in zebrafish oogenesis and embryogenesis. RNA (New York, N.Y.). 24(12):1738-1748
- Dankert, J.F., Rona, G., Clijsters, L., Geter, P., Skaar, J.R., Bermudez-Hernandez, K., Sassani, E., Fenyö, D., Ueberheide, B., Schneider, R., Pagano, M. (2016) Cyclin F-Mediated Degradation of SLBP Limits H2A.X Accumulation and Apoptosis upon Genotoxic Stress in G2. Molecular Cell. 64:507-519
- Imai, F., Yoshizawa, A., Matsuzaki, A., Oguri, E., Araragi, M., Nishiwaki, Y., Masai, I. (2014) Stem-loop binding protein is required for retinal cell proliferation, neurogenesis, and intraretinal axon pathfinding in zebrafish. Developmental Biology. 394(1):94-109
- Wu, C.C., Tsai, T.H., Chang, C., Lee, T.T., Lin, C., Cheng, I.H., Sun, M.C., Chuang, Y.J., Chen, B.S. (2014) On the Crucial Cerebellar Wound Healing-Related Pathways and Their Cross-Talks after Traumatic Brain Injury in Danio rerio. PLoS One. 9:e97902
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
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