Gene
plcg2
- ID
- ZDB-GENE-030131-9532
- Name
- phospholipase C, gamma 2
- Symbol
- plcg2 Nomenclature History
- Previous Names
-
- fj85b03
- sb:eu1064
- si:ch211-260p9.2
- wu:fj85b03
- zgc:152893
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable phosphatidylinositol phospholipase C activity. Predicted to act upstream of or within intracellular signal transduction and phospholipid catabolic process. Human ortholog(s) of this gene implicated in familial cold autoinflammatory syndrome 3. Orthologous to human PLCG2 (phospholipase C gamma 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2005
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu1064 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autoinflammation, antibody deficiency, and immune dysregulation syndrome | Alliance | Autoinflammation, antibody deficiency, and immune dysregulation syndrome | 614878 |
| familial cold autoinflammatory syndrome 3 | Alliance | Familial cold autoinflammatory syndrome 3 | 614468 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000008 | C2 domain |
| Domain | IPR000909 | Phosphatidylinositol-specific phospholipase C, X domain |
| Domain | IPR000980 | SH2 domain |
| Domain | IPR001452 | SH3 domain |
| Domain | IPR001711 | Phospholipase C, phosphatidylinositol-specific, Y domain |
| Domain | IPR001849 | Pleckstrin homology domain |
| Domain | IPR035023 | PLC-gamma, C-terminal SH2 domain |
| Domain | IPR035024 | PLC-gamma, N-terminal SH2 domain |
| Domain | IPR035723 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2, SH3 domain |
| Family | IPR001192 | Phosphoinositide phospholipase C family |
| Family | IPR016279 | Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma |
| Homologous_superfamily | IPR011992 | EF-hand domain pair |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR017946 | PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily |
| Homologous_superfamily | IPR035892 | C2 domain superfamily |
| Homologous_superfamily | IPR036028 | SH3-like domain superfamily |
| Homologous_superfamily | IPR036860 | SH2 domain superfamily |
Domain Details Per Protein
| Protein | Length | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2, SH3 domain | C2 domain | C2 domain superfamily | EF-hand domain pair | PH-like domain superfamily | Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma | Phosphatidylinositol-specific phospholipase C, X domain | Phosphoinositide phospholipase C family | Phospholipase C, phosphatidylinositol-specific, Y domain | PLC-gamma, C-terminal SH2 domain | PLC-gamma, N-terminal SH2 domain | PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily | Pleckstrin homology domain | SH2 domain | SH2 domain superfamily | SH3 domain | SH3-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q1LWV8
|
1240 |
Interactions and Pathways
No data available
Plasmids
No data available