Gene

tgfbi

ID

ZDB-GENE-030131-73

Name

transforming growth factor, beta-induced

Symbol

tgfbi Nomenclature History

Previous Names

big-h3 (1)
etID38199.14 (1)
hm:zeh0933
wu:fa13f05 (1)
zgc:110495

Type

protein_coding_gene

Location

Chr: 14 Mapping Details/Browsers

Description

Predicted to have cell adhesion molecule binding activity. Involved in cellular response to xenobiotic stimulus and muscle fiber development. Predicted to localize to extracellular matrix and extracellular space. Human ortholog(s) of this gene implicated in corneal dystrophy (multiple). Is expressed in several structures, including head mesenchyme; liver; neural crest cell; paraxial mesoderm; and splanchnocranium. Orthologous to human TGFBI (transforming growth factor beta induced).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

25 figures from 13 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

IMAGE:6903641 (23 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from Kim et al., 2009
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tgfbi Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
epithelial basement membrane dystrophy	Alliance	Corneal dystrophy, epithelial basement membrane	121820
granular corneal dystrophy 1	Alliance	Corneal dystrophy, Groenouw type I	121900
granular corneal dystrophy 2	Alliance	Corneal dystrophy, Avellino type	607541
lattice corneal dystrophy	Alliance	Corneal dystrophy, lattice type I	122200
Reis-Bucklers corneal dystrophy	Alliance	Corneal dystrophy, Reis-Bucklers type	608470
Thiel-Behnke corneal dystrophy	Alliance	Corneal dystrophy, Thiel-Behnke type	602082
		Corneal dystrophy, lattice type IIIA	608471

Associated With tgfbi Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000782	FAS1 domain
Domain	IPR011489	EMI domain
Family	IPR016666	TGF beta-induced protein/periostin
Homologous_superfamily	IPR036378	FAS1 domain superfamily