Gene
prkcda
- ID
- ZDB-GENE-030131-6503
- Name
- protein kinase C, delta a
- Symbol
- prkcda Nomenclature History
- Previous Names
-
- prkcd
- fb09d10
- fv43b11
- wu:fb09d10
- wu:fv43b11
- zgc:56558
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction. Predicted to act upstream of or within apoptotic process and protein phosphorylation. Located in immunological synapse. Is expressed in blood; myotome; nervous system; otic vesicle; and somite. Human ortholog(s) of this gene implicated in autoimmune lymphoproliferative syndrome type 3; hypertension; and steatotic liver disease. Orthologous to human PRKCD (protein kinase C delta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7149633 (12 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-prkcda | Munson et al., 2021 | |
| CRISPR2-prkcda | Munson et al., 2021 | |
| CRISPR3-prkcda | Munson et al., 2021 | |
| CRISPR4-prkcda | Binder et al., 2023 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autoimmune lymphoproliferative syndrome type 3 | Alliance | Autoimmune lymphoproliferative syndrome, type III | 615559 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000008 | C2 domain |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR000961 | AGC-kinase, C-terminal |
| Domain | IPR002219 | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain |
| Domain | IPR017892 | Protein kinase, C-terminal |
| Domain | IPR020454 | Diacylglycerol/phorbol-ester binding |
| Domain | IPR034667 | Novel protein kinase C delta, catalytic domain |
| Family | IPR014376 | Protein kinase C, delta/epsilon/eta/theta types |
| Family | IPR027436 | Protein kinase C, delta |
| Family | IPR050236 | Serine/threonine-protein kinases, AGC |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR035892 | C2 domain superfamily |
| Homologous_superfamily | IPR046349 | C1-like domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | AGC-kinase, C-terminal | C1-like domain superfamily | C2 domain | C2 domain superfamily | Diacylglycerol/phorbol-ester binding | Novel protein kinase C delta, catalytic domain | Protein kinase, ATP binding site | Protein kinase C, delta | Protein kinase C, delta/epsilon/eta/theta types | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain | Protein kinase, C-terminal | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site | Serine/threonine-protein kinases, AGC |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q7ZUC5 | InterPro | 684 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
prkcda-201
(1)
|
Ensembl | 2,908 nt |
Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(sele:prkcda-2A-mCherry) |
| 1 | Binder et al., 2023 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-15B2 | ZFIN Curated Data | |
| Encodes | EST | fb09d10 | ZFIN Curated Data | |
| Encodes | EST | fv43b11 | ||
| Encodes | EST | IMAGE:7149633 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:56558 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_214708 (1) | 2918 nt | ||
| Genomic | GenBank:CU463231 (1) | 104010 nt | ||
| Polypeptide | UniProtKB:Q7ZUC5 (1) | 684 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | PRKCD | 3 | Phylogenetic tree (1) Amino acid sequence comparison (1) Nucleotide sequence comparison (1) Conserved genome location (synteny) (1) | |
| Mouse | Prkcd | 14 | Conserved genome location (synteny) (1) Nucleotide sequence comparison (1) Amino acid sequence comparison (1) Phylogenetic tree (1) |
- Binder, V., Li, W., Faisal, M., Oyman, K., Calkins, D.L., Shaffer, J., Teets, E.M., Sher, S., Magnotte, A., Belardo, A., Deruelle, W., Gregory, T.C., Orwick, S., Hagedorn, E.J., Perlin, J.R., Avagyan, S., Lichtig, A., Barrett, F., Ammerman, M., Yang, S., Zhou, Y., Carson, W.E., Shive, H.R., Blachly, J.S., Lapalombella, R., Zon, L.I., Blaser, B.W. (2023) Microenvironmental control of hematopoietic stem cell fate via CXCL8 and protein kinase C. Cell Reports. 42:112528112528
- Garcia-Concejo, A., Larhammar, D. (2021) Protein kinase C family evolution in jawed vertebrates. Developmental Biology. 479:77-90
- Munson, M.J., Mathai, B.J., Ng, M.Y.W., Trachsel-Moncho, L., de la Ballina, L.R., Schultz, S.W., Aman, Y., Lystad, A.H., Singh, S., Singh, S., Wesche, J., Fang, E.F., Simonsen, A. (2021) GAK and PRKCD are positive regulators of PRKN-independent mitophagy. Nature communications. 12:6101
- Chen, Z.L., Gong, B.N., Wang, Q.L., Xiao, Z.H., Deng, C., Wang, W.Q., Li, Y. (2018) Characterisation of amphioxus protein kinase C-δ/θ reveals a unique proto-V3 domain suggesting an evolutionary mechanism for PKC-θ unique V3. Fish & shellfish immunology. 84:1100-1107
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Qvit, N., Joshi, A.U., Cunningham, A.D., Ferreira, J.C., Mochly-Rosen, D. (2016) Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) Protein-Protein Interaction Inhibitor Reveals a Non-catalytic Role for GAPDH Oligomerization in Cell Death. The Journal of biological chemistry. 291:13608-21
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Lim, A., Moussavi Nik, S.H., Ebrahimie, E., Lardelli, M. (2015) Analysis of nicastrin gene phylogeny and expression in zebrafish. Development genes and evolution. 225(3):171-8
- Schmitt, C.E., Woolls, M.J., and Jin, S.W. (2013) Mutant-specific gene expression profiling identifies SRY-related HMG box 11b (SOX11b) as a novel regulator of vascular development in zebrafish. Molecules and cells. 35(2):166-172
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