ZFIN ID: ZDB-GENE-030131-5602
Gene Name: aldehyde dehydrogenase 18 family, member A1
Gene Symbol: aldh18a1
Previous Names: cb842 (1), cb899 (1), pycs (1), sb:cb881, wu:fa91f10, wu:fi05f11, wu:fi17d12
Location: Chr: 12 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
Directly Submitted Expression Data: 4 figures (5 images) from Thisse et al., 2001 [cb899]
  12 figures (29 images) from Rauch et al., 2003 [fi50d09]
  6 figures (14 images) from Thisse et al., 2004 [IMAGE:7165398]
  5 figures (12 images) from Thisse et al., 2001 [cb842]
  4 figures (3 images) from Thisse et al., 2001 [cb881]
Wild-type Stages, Structures: Cleavage:2-cell (0.75h-1.0h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
  alar plate midbrain region, brain, endocrine system, epidermis (all 22) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la018205Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa35325 Point Mutation Unknown Unknown ENU
    Targeting reagents: MO1-aldh18a1 (1)
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH aldh18a1 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    cutis laxa Cutis laxa, autosomal recessive, type IIIA 219150
    hereditary spastic paraplegia Spastic paraplegia 9A, autosomal dominant 601162
    Spastic paraplegia 9B, autosomal recessive 616586
    Cutis laxa, autosomal dominant 3 616603
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process metabolic process (more)
    Cellular Component cytoplasm (more)
    Molecular Function catalytic activity (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000965 (1)
  • InterPro:IPR001048 (1)
  • InterPro:IPR001057 (1)
  • InterPro:IPR005715 (1)
  • InterPro:IPR005766 (1)
  • InterPro:IPR015590 (1)
  • InterPro:IPR016161 (1)
  • InterPro:IPR016162 (1)
  • InterPro:IPR016163 (1)
  • InterPro:IPR019797 (1)
  • InterPro:IPR020593 (1)
  • PROSITE:PS00902 (1)
  • PROSITE:PS01223 (1)
  • Pfam:PF00171 (1)
  • Pfam:PF00696 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA aldh18a1-001 (1) 4416
    GENE PRODUCT DESCRIPTION No description available
    INTERACTIONS AND PATHWAYSNo data available
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM aldh18a1 No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    aldh18a1Contained in: [BAC] CH211-140C18 (1) (order this), DKEY-41E15 (1) (order this)
    aldh18a1Contains: [SNP] rs3728509 (1)
    aldh18a1Encodes: [EST] cb842 (1) (order this), cb881 (1) (order this), cb899 (1) (order this), fa91f10, fi05f11, fi17d12, fi50d09 (1) (order this), IMAGE:7165398 (1) (order this)
    [cDNA] MGC:162616 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001083546 (1) 4424bp
    Genomic GenBank:CR751608 (1) 209340bp Blast at MegaBLAST
    Polypeptide UniProtKB:A4IGC8 (1) 782aa
    Sequence Clusters UniGene:76195 (1)
    Sequence Information (all 24)
    OTHER aldh18a1 GENE PAGES
  • Gene:557186 (1)
  • VEGA:OTTDARG00000027405 (1)
  • Ensembl(GRCz10):ENSDARG00000099579 (1)
  • ORTHOLOGY for aldh18a1 (Chr: 12)
    Species Symbol Chromosome Accession # Evidence
    Human ALDH18A1 10
  • Gene:5832
  • OMIM:138250
  • HGNC:9722
  • Amino acid sequence comparison (3)
    Conserved genome location (synteny) (1)
    Mouse Aldh18a1 19
  • MGI:1888908
  • Gene:56454
  • Amino acid sequence comparison (1)
    Download Curated Orthology
    CITATIONS (26)