ZFIN ID: ZDB-GENE-030131-5602
Gene Name: aldehyde dehydrogenase 18 family, member A1
Gene Symbol: aldh18a1
Previous Names: cb842 (1), cb899 (1), pycs (1), sb:cb881, wu:fa91f10, wu:fi05f11, wu:fi17d12
Location: Chr: 12   Details
Nomenclature History
GENE EXPRESSION
Directly Submitted Expression Data: 12 figures (29 images) from Rauch et al., 2003 [fi50d09]
  4 figures (5 images) from Thisse et al., 2001 [cb899]
  6 figures (14 images) from Thisse et al., 2004 [IMAGE:7165398]
  5 figures (12 images) from Thisse et al., 2001 [cb842]
  4 figures (3 images) from Thisse et al., 2001 [cb881]
Wild-type Stages, Structures: Cleavage:2-cell (0.75h-1.0h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
  alar plate midbrain region, brain, endocrine system, epidermis (all 22) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Alleles: la018205Tg
Knockdown reagents: MO1-aldh18a1 (1)
PHENOTYPE
Phenotype of Human Orthologue OMIM Phenotype ID
Cutis laxa, autosomal recessive, type IIIA 219150
GENE ONTOLOGY
Ontology GO Term
Biological Process metabolic process (more)
Cellular Component cytoplasm (more)
Molecular Function catalytic activity (more)
GO Terms (all 11)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000965 (1)
  • InterPro:IPR001048 (1)
  • InterPro:IPR001057 (1)
  • InterPro:IPR005715 (1)
  • InterPro:IPR005766 (1)
  • InterPro:IPR015590 (1)
  • InterPro:IPR016161 (1)
  • InterPro:IPR016162 (1)
  • InterPro:IPR016163 (1)
  • InterPro:IPR019797 (1)
  • InterPro:IPR020593 (1)
  • PROSITE:PS00902 (1)
  • PROSITE:PS01223 (1)
  • Pfam:PF00171 (1)
  • Pfam:PF00696 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA aldh18a1-001 (1) 4416
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM aldh18a1 No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    aldh18a1 Contained in: [BAC] CH211-140C18 (1) (order this), DKEY-41E15 (1)
    aldh18a1 Contains: [SNP] rs3728509 (1)
    aldh18a1 Encodes: [EST] cb842 (1) (order this), cb881 (1) (order this), cb899 (1) (order this), fa91f10, fi05f11, fi17d12, fi50d09 (1), IMAGE:7165398 (1) (order this)
    [cDNA] MGC:162616 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001083546 (1) 4424 bp
    Genomic GenBank:CR751608 (1) 209340 bp Blast at MegaBLAST
    Polypeptide UniProtKB:E7EZW8 (1) 784 aa
    Sequence Clusters UniGene:76195 (1)
    Sequence Information (all 25)
    OTHER aldh18a1 GENE PAGES
  • Gene:557186 (1)
  • VEGA:OTTDARG00000027405 (1)
  • Ensembl(Zv9):ENSDARG00000061123 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish aldh18a1 12  
    Human ALDH18A1 10 (10q24.3)
  • OMIM:138250
  • Gene:5832
  • Mouse Aldh18a1 19 ( 34.25 cM)
  • MGI:1888908
  • Gene:56454
  • Orthology Details
    CITATIONS (25)