Gene
zbtb16a
- ID
- ZDB-GENE-030131-1989
- Name
- zinc finger and BTB domain containing 16a
- Symbol
- zbtb16a Nomenclature History
- Previous Names
-
- zbtb16
- plzfa (1)
- wu:fb93g12
- wu:fc07c10
- zgc:55675
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to have DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II regulatory region sequence-specific DNA binding activity. Involved in positive regulation of type I interferon production and regulation of neurogenesis. Localizes to nucleus. Human ortholog(s) of this gene implicated in acute promyelocytic leukemia. Is expressed in several structures, including anterior neural keel; anterior neural rod; central nervous system; pleuroperitoneal region; and posterior neural rod. Orthologous to human ZBTB16 (zinc finger and BTB domain containing 16).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55675 (20 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Wu et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Leukemia, acute promyelocytic, PL2F/RARA type |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000210 | BTB/POZ domain |
| Domain | IPR013087 | Zinc finger C2H2-type |
| Family | IPR050457 | Zinc finger and BTB domain-containing |
| Family | IPR050527 | Snail/Krueppel C2H2-type Zinc-finger |
| Homologous_superfamily | IPR011333 | SKP1/BTB/POZ domain superfamily |
| Homologous_superfamily | IPR036236 | Zinc finger C2H2 superfamily |
Domain Details Per Protein
| Protein | Length | BTB/POZ domain | SKP1/BTB/POZ domain superfamily | Snail/Krueppel C2H2-type Zinc-finger | Zinc finger and BTB domain-containing | Zinc finger C2H2 superfamily | Zinc finger C2H2-type |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q802Y8
|
671 | ||||||
|
UniProtKB:E7FDS7
|
670 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
zbtb16a-201
(1)
|
Ensembl | 7,407 nt | ||
| mRNA |
zbtb16a-202
(1)
|
Ensembl | 1,445 nt | ||
| mRNA |
zbtb16a-203
(1)
|
Ensembl | 1,485 nt | ||
| mRNA |
zbtb16a-204
(1)
|
Ensembl | 2,074 nt | ||
| mRNA |
zbtb16a-205
(1)
|
Ensembl | 7,441 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-zbtb16a | polyclonal | Rabbit |
|
3 |
Plasmids
No data available