Gene

zbtb16a

ID
ZDB-GENE-030131-1989
Name
zinc finger and BTB domain containing 16a
Symbol
zbtb16a Nomenclature History
Previous Names
  • zbtb16
  • plzfa (1)
  • wu:fb93g12
  • wu:fc07c10
  • zgc:55675
Type
protein_coding_gene
Location
Chr: 21 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of type I interferon production and regulation of neurogenesis. Localizes to nucleus. Is expressed in several structures, including anterior neural keel; anterior neural rod; central nervous system; pleuroperitoneal region; and posterior neural rod. Human ortholog(s) of this gene implicated in acute promyelocytic leukemia. Orthologous to human ZBTB16 (zinc finger and BTB domain containing 16).
Genome Resources
Note
None
Expression
All Expression Data
14 figures from 7 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
Fig. 7 from Wu et al., 2018
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With zbtb16a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Leukemia, acute promyelocytic, PL2F/RARA type
Skeletal defects, genital hypoplasia, and mental retardation 612447
Associated With zbtb16a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000210 BTB/POZ domain
Domain IPR013087 Zinc finger C2H2-type
Homologous_superfamily IPR011333 SKP1/BTB/POZ domain superfamily
Homologous_superfamily IPR036236 Zinc finger C2H2 superfamily
Domain Details Per Protein
Protein Length BTB/POZ domain SKP1/BTB/POZ domain superfamily Zinc finger C2H2 superfamily Zinc finger C2H2-type
UniProtKB:E9QG48 420
UniProtKB:A0A2R8QFN0 671
UniProtKB:B2GRR7 671
UniProtKB:E7FDS7 670
UniProtKB:Q802Y8 671
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-zbtb16a polyclonal Rabbit
  • IHC
  • WB
3
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations