ZFIN ID: ZDB-GENE-030131-1989
Gene Name: zinc finger and BTB domain containing 16a
Gene Symbol: zbtb16a    Nomenclature History

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Previous Names: zbtb16, plzfa (1), wu:fb93g12, wu:fc07c10, zgc:55675

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of type I interferon production and regulation of neurogenesis. Localizes to nucleus. Is expressed in several structures, including anterior neural keel; anterior neural rod; central nervous system; pleuroperitoneal region; and posterior neural rod. Human ortholog(s) of this gene implicated in acute promyelocytic leukemia. Orthologous to human ZBTB16 (zinc finger and BTB domain containing 16).
Genome Resources: Alliance (1),  Gene:323269 (1),  Ensembl(GRCz11):ENSDARG00000007184 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
zf2179 Small Deletion Unknown Unknown CRISPR
zf2180 Insertion Unknown Unknown CRISPR
zf2181 Complex Unknown Unknown CRISPR
PHENOTYPE
Data: Fig. 7 from Wu et al., 2018
Observed in:
DISEASE ASSOCIATED WITH zbtb16a HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Leukemia, acute promyelocytic, PL2F/RARA type
Skeletal defects, genital hypoplasia, and mental retardation 612447
DISEASE ASSOCIATED WITH zbtb16a VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process positive regulation of type I interferon production (more)
Cellular Component nucleus (more)
Molecular Function DNA binding (more)
GO Terms (all 11)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA zbtb16a-202 (1)    Ensembl 1445
zbtb16a-203 (1)    Ensembl 1485
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab1-zbtb16a polyclonal Rabbit IHC, WB 3
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM zbtb16a No data available
MARKER RELATIONSHIPS
zbtb16a Contained in: [BAC] CH211-158E11 (1)
[Fosmid] CH1073-79B16 (1)
zbtb16a Encodes: [EST] fb93g12, fc07c10, wz12306 (1)
[cDNA] MGC:55675 (1), MGC:193090 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_199635 (1) 2326 nt
Genomic GenBank:CR388411 (1) 146786 nt
Select Tool
Polypeptide UniProtKB:A0A2R8QFN0 (1) 671 aa
Sequence Information (all 28)
ORTHOLOGY for zbtb16a ( Chr: 21 )
CITATIONS (34)