Gene
glud1a
- ID
- ZDB-GENE-030114-2
- Name
- glutamate dehydrogenase 1a
- Symbol
- glud1a Nomenclature History
- Previous Names
-
- glud1
- cb622 (1)
- wu:fc33g09
- wu:fc66a10
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable glutamate dehydrogenase (NAD+) activity. Predicted to be involved in L-glutamate catabolic process. Predicted to act upstream of or within amino acid metabolic process. Predicted to be active in mitochondrion. Is expressed in several structures, including cardiovascular system; digestive system; nervous system; periderm; and pronephros. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 6; hyperinsulinism; and hypoglycemia. Orthologous to human GLUD1 (glutamate dehydrogenase 1) and GLUD2 (glutamate dehydrogenase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 26 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb622 (24 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-glud1a | LaCoursiere et al., 2024 | |
| CRISPR2-glud1a | LaCoursiere et al., 2024 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| familial hyperinsulinemic hypoglycemia 6 | Alliance | Hyperinsulinism-hyperammonemia syndrome | 606762 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR033524 | Leu/Phe/Val dehydrogenases active site |
| Domain | IPR006096 | Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase, C-terminal |
| Domain | IPR006097 | Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase, dimerisation domain |
| Domain | IPR033922 | NAD(P) binding domain of glutamate dehydrogenase |
| Family | IPR006095 | Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Aminoacid dehydrogenase-like, N-terminal domain superfamily | Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase | Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase, C-terminal | Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase, dimerisation domain | Leu/Phe/Val dehydrogenases active site | NAD(P) binding domain of glutamate dehydrogenase | NAD(P)-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6NZ29 | InterPro | 544 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
glud1a-201
(1)
|
Ensembl | 2,482 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-134M17 | ZFIN Curated Data | |
| Encodes | EST | cb622 | Thisse et al., 2001 | |
| Encodes | EST | fc33g09 | ZFIN Curated Data | |
| Encodes | EST | fc66a10 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77186 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_212576 (1) | 2520 nt | ||
| Genomic | GenBank:BX005174 (1) | 178371 nt | ||
| Polypeptide | UniProtKB:Q6NZ29 (1) | 544 aa |
- LaCoursiere, C.M., Ullmann, J.F.P., Koh, H.Y., Turner, L., Baker, C.M., Robens, B., Shao, W., Rotenberg, A., McGraw, C.M., Poduri, A.H. (2024) Zebrafish models of candidate human epilepsy-associated genes provide evidence of hyperexcitability. iScience. 27:110172110172
- Huang, L., Han, F., Huang, Y., Liu, J., Liao, X., Cao, Z., Li, W. (2023) Sphk1 deficiency induces apoptosis and developmental defects and premature death in zebrafish. Fish physiology and biochemistry. 49(4):737-750
- Ding, Q., Lu, C., Hao, Q., Zhang, Q., Yang, Y., Olsen, R.E., Ringo, E., Ran, C., Zhang, Z., Zhou, Z. (2022) Dietary Succinate Impacts the Nutritional Metabolism, Protein Succinylation and Gut Microbiota of Zebrafish. Frontiers in nutrition. 9:894278
- Shi, Z., Liang, X., Zhao, Y., Liu, W., Martyniuk, C.J. (2022) Neurotoxic effects of synthetic phenolic antioxidants on dopaminergic, serotoninergic, and GABAergic signaling in larval zebrafish (Danio rerio). The Science of the total environment. 830:154688
- Wang, J.G., Zhao, S.H., Qian, Y.C., Qian, Y.F., Liu, Y.C., Qiao, F., Luo, Y., Zhang, M.L., Du, Z.Y. (2022) The dysfunction of hormone-sensitive lipase induces lipid deposition and reprogramming of nutrient metabolism. The British journal of nutrition. 130(4):588-603
- Wu, X., Chen, J., Liu, C., Wang, X., Zhou, H., Mai, K., He, G. (2022) Slc38a9 Deficiency Induces Apoptosis and Metabolic Dysregulation and Leads to Premature Death in Zebrafish. International Journal of Molecular Sciences. 23(8):
- Cao, Z., Su, M., Wang, H., Zhou, L., Meng, Z., Xiong, G., Liao, X., Lu, H. (2020) Carboxyl graphene oxide nanoparticles induce neurodevelopmental defects and locomotor disorders in zebrafish larvae. Chemosphere. 270:128611
- Gong, G., Chen, H., Kam, H., Chan, G., Tang, Y.X., Wu, M., Tan, H., Tse, Y.C., Xu, H.X., Lee, S.M. (2020) In Vivo Screening of Xanthones from Garcinia oligantha Identified Oliganthin H as a Novel Natural Inhibitor of Convulsions. Journal of natural products. 83(12):3706-3716
- Li, L.Y., Li, J.M., Ning, L.J., Lu, D.L., Luo, Y., Ma, Q., Limbu, S.M., Li, D.L., Chen, L.Q., Lodhi, I.J., Degrace, P., Zhang, M.L., Du, Z.Y. (2020) Mitochondrial Fatty Acid β-Oxidation Inhibition Promotes Glucose Utilization and Protein Deposition through Energy Homeostasis Remodeling in Fish. The Journal of nutrition. 150(9):2322-2335
- Li, X., Schmöhl, F., Qi, H., Bennewitz, K., Tabler, C.T., Poschet, G., Hell, R., Volk, N., Poth, T., Hausser, I., Morgenstern, J., Fleming, T., Nawroth, P.P., Kroll, J. (2020) Regulation of Gluconeogenesis by Aldo-keto-reductase 1a1b in Zebrafish. iScience. 23:101763
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