Gene
pals1a
- ID
- ZDB-GENE-020712-1
- Name
- protein associated with LIN7 1, MAGUK p55 family member a
- Symbol
- pals1a Nomenclature History
- Previous Names
-
- mpp5
- mpp5a
- nagie oko
- nok
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable ATP binding activity. Acts upstream of or within several processes, including embryonic morphogenesis; heart development; and nervous system development. Located in several cellular components, including apical junction complex; nucleus; and photoreceptor inner segment. Is expressed in several structures, including EVL; brain; eye; neural tube; and pronephros. Orthologous to human PALS1 (protein associated with LIN7 1, MAGUK p55 family member).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 18 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 48 figures from 25 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR020590 | Guanylate kinase, conserved site |
| Domain | IPR001452 | SH3 domain |
| Domain | IPR001478 | PDZ domain |
| Domain | IPR004172 | L27 domain |
| Domain | IPR008144 | Guanylate kinase-like domain |
| Domain | IPR008145 | Guanylate kinase/L-type calcium channel beta subunit |
| Domain | IPR014775 | L27 domain, C-terminal |
| Domain | IPR015145 | L27-N |
| Domain | IPR035601 | MPP5, SH3 domain |
| Family | IPR050716 | Membrane-associated guanylate kinase |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036028 | SH3-like domain superfamily |
| Homologous_superfamily | IPR036034 | PDZ superfamily |
| Homologous_superfamily | IPR036892 | L27 domain superfamily |
Domain Details Per Protein
| Protein | Length | Guanylate kinase, conserved site | Guanylate kinase-like domain | Guanylate kinase/L-type calcium channel beta subunit | L27 domain | L27 domain, C-terminal | L27 domain superfamily | L27-N | Membrane-associated guanylate kinase | MPP5, SH3 domain | PDZ domain | PDZ superfamily | P-loop containing nucleoside triphosphate hydrolase | SH3 domain | SH3-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q8JHF4
|
677 | ||||||||||||||
|
UniProtKB:B3DIW9
|
703 | ||||||||||||||
|
UniProtKB:Q1LVF4
|
703 |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-pals1a | Rabbit |
|
2 | ||||
| Ab3-pals1a | polyclonal | Rabbit |
|
10 | |||
| Ab2-pals1a | polyclonal | Rabbit |
|
2 |
Plasmids
No data available