Gene
ugdh
- ID
- ZDB-GENE-011022-1
- Name
- UDP-glucose 6-dehydrogenase
- Symbol
- ugdh Nomenclature History
- Previous Names
-
- ik:tdsubc_2a8 (1)
- jek
- jekyll
- sb:eu659
- tdsubc_2a8
- xx:tdsubc_2a8
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable NAD binding activity and UDP-glucose 6-dehydrogenase activity. Acts upstream of or within atrioventricular valve formation; determination of left/right symmetry; and positive regulation of signal transduction. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including axis; head; heart tube; mesoderm; and vestibuloauditory system. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 84. Orthologous to human UGDH (UDP-glucose 6-dehydrogenase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu659 (12 images)
Wild Type Expression Summary
- All Phenotype Data
- 23 figures from 7 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| developmental and epileptic encephalopathy 84 | Alliance | Developmental and epileptic encephalopathy 84 | 618792 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001732 | UDP-glucose/GDP-mannose dehydrogenase, N-terminal |
| Domain | IPR014026 | UDP-glucose/GDP-mannose dehydrogenase, dimerisation |
| Domain | IPR014027 | UDP-glucose/GDP-mannose dehydrogenase, C-terminal |
| Family | IPR017476 | UDP-glucose/GDP-mannose dehydrogenase |
| Family | IPR028356 | UDP-glucose 6-dehydrogenase, eukaryotic type |
| Homologous_superfamily | IPR008927 | 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily |
| Homologous_superfamily | IPR036220 | UDP-glucose/GDP-mannose dehydrogenase, C-terminal domain superfamily |
| Homologous_superfamily | IPR036291 | NAD(P)-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily | NAD(P)-binding domain superfamily | UDP-glucose 6-dehydrogenase, eukaryotic type | UDP-glucose/GDP-mannose dehydrogenase | UDP-glucose/GDP-mannose dehydrogenase, C-terminal | UDP-glucose/GDP-mannose dehydrogenase, C-terminal domain superfamily | UDP-glucose/GDP-mannose dehydrogenase, dimerisation | UDP-glucose/GDP-mannose dehydrogenase, N-terminal |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A8WGP7
|
493 |
Interactions and Pathways
No data available
Plasmids
No data available