Gene
ednraa
- ID
- ZDB-GENE-010906-2
- Name
- endothelin receptor type Aa
- Symbol
- ednraa Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable endothelin receptor activity. Acts upstream of with a positive effect on developmental pigmentation. Acts upstream of or within cartilage development; regulation of proton transport; and social behavior. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including epithelium; forebrain; neural crest; pharyngeal arch; and vasculature. Human ortholog(s) of this gene implicated in hypertension (multiple); lung disease; mandibulofacial dysostosis with alopecia; migraine; and obstructive sleep apnea. Orthologous to human EDNRA (endothelin receptor type A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 20 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hu4140 | Allele with one point mutation | Exon 5 | Premature Stop | ENU | |
| sa1973 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa11317 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa13839 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa19531 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa19532 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa32714 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| tj262 | unknown | Unknown | Exon Loss of Exon 7, Frameshift | ENU | |
| tv212 | unknown | Unknown | Exon Loss of Exon 6, Frameshift | ENU | |
| yzu4Et | Transgenic insertion | Unknown | Unknown | DNA |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO2-ednraa | N/A | (3) |
| MO3-ednraa | N/A | Guh et al., 2014 |
| MO4-ednraa | N/A | Camargo-Sosa et al., 2019 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Endothelin receptor A | Endothelin receptor family | GPCR, rhodopsin-like, 7TM | G-protein coupled endothelin receptor | G protein-coupled receptor, rhodopsin-like |
|---|---|---|---|---|---|---|
|
UniProtKB:B3DLG5
|
422 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ednraa-201
(1)
|
Ensembl | 2,665 nt | ||
| mRNA |
ednraa-203
(1)
|
Ensembl | 200 nt | ||
| mRNA |
ednraa-204
(1)
|
Ensembl | 1,656 nt | ||
| mRNA |
ednraa-205
(1)
|
Ensembl | 1,690 nt | ||
| mRNA |
ednraa-206
(1)
|
Ensembl | 1,436 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-172J10 | ZFIN Curated Data | |
| Encodes | EST | fb75g12 | ||
| Encodes | cDNA | MGC:172066 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193800 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001099445 (1) | 2742 nt | ||
| Genomic | GenBank:AL928968 (1) | 173210 nt | ||
| Polypeptide | UniProtKB:B3DLG5 (1) | 422 aa |
- Okeke, C., Paulding, D., Riedel, A., Paudel, S., Phelan, C., Teng, C.S., Barske, L. (2022) Control of cranial ectomesenchyme fate by Nr2f nuclear receptors. Development (Cambridge, England). 149(23):
- Kowatschew, D., Korsching, S.I. (2021) An ancient adenosine receptor gains olfactory function in bony vertebrates. Genome biology and evolution. 13(9)
- Postlethwait, J.H., Massaquoi, M.S., Farnsworth, D.R., Yan, Y.L., Guillemin, K., Miller, A.C. (2021) The SARS-CoV-2 receptor and other key components of the Renin-Angiotensin-Aldosterone System related to COVID-19 are expressed in enterocytes in larval zebrafish. Biology Open. 10(3):
- Chen, J.W., Niu, X., King, M.J., Noedl, M.T., Tabin, C.J., Galloway, J.L. (2020) The mevalonate pathway is a critical regulator of tendon cell specification. Development (Cambridge, England). 147(12):
- Postlethwait, J.H., Farnsworth, D.R., Miller, A.C. (2020) An intestinal cell type in zebrafish is the nexus for the SARS-CoV-2 receptor and the Renin-Angiotensin-Aldosterone System that contributes to COVID-19 comorbidities. ZFIN Direct Data Submission.
- Camargo-Sosa, K., Colanesi, S., Müller, J., Schulte-Merker, S., Stemple, D., Patton, E.E., Kelsh, R.N. (2019) Endothelin receptor Aa regulates proliferation and differentiation of Erb-dependent pigment progenitors in zebrafish. PLoS Genetics. 15:e1007941
- Carreño Gutiérrez, H., Colanesi, S., Cooper, B., Reichmann, F., Young, A.M.J., Kelsh, R.N., Norton, W.H.J. (2019) Endothelin neurotransmitter signalling controls zebrafish social behaviour. Scientific Reports. 9:3040
- Xue, Y., Liu, D., Cui, G., Ding, Y., Ai, D., Gao, S., Zhang, Y., Suo, S., Wang, X., Lv, P., Zhou, C., Li, Y., Chen, X., Peng, G., Jing, N., Han, J.J., Liu, F. (2019) A 3D Atlas of Hematopoietic Stem and Progenitor Cell Expansion by Multi-dimensional RNA-Seq Analysis. Cell Reports. 27:1567-1578.e5
- Barske, L., Rataud, P., Behizad, K., Del Rio, L., Cox, S.G., Crump, J.G. (2018) Essential Role of Nr2f Nuclear Receptors in Patterning the Vertebrate Upper Jaw. Developmental Cell. 44(3):337-347.e5
- Sharma, P., MacLean, A.L., Meinecke, L., Clouthier, D., Nie, Q., Schilling, T.F. (2018) Transcriptomics reveals complex kinetics of dorsal-ventral patterning gene expression in the mandibular arch. Genesis (New York, N.Y. : 2000). 57(1):e23275
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