Gene
vars1
- ID
- ZDB-GENE-010601-1
- Name
- valyl-tRNA synthetase 1
- Symbol
- vars1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to have valine-tRNA ligase activity. Predicted to be involved in valyl-tRNA aminoacylation. Predicted to localize to cytosol. Is expressed in digestive system; immature eye; intermediate cell mass of mesoderm; nervous system; and somite. Orthologous to human VARS1 (valyl-tRNA synthetase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7137378 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Neurodevelopmental disorder with microcephaly, seizures, and cortical atrophy | 617802 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR001412 | Aminoacyl-tRNA synthetase, class I, conserved site |
| Domain | IPR002300 | Aminoacyl-tRNA synthetase, class Ia |
| Domain | IPR004046 | Glutathione S-transferase, C-terminal |
| Domain | IPR010987 | Glutathione S-transferase, C-terminal-like |
| Domain | IPR013155 | Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding |
| Domain | IPR033705 | Valyl tRNA synthetase, anticodon-binding domain |
| Family | IPR002303 | Valine-tRNA ligase |
| Homologous_superfamily | IPR009008 | Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain |
| Homologous_superfamily | IPR009080 | Aminoacyl-tRNA synthetase, class Ia, anticodon-binding |
| Homologous_superfamily | IPR014729 | Rossmann-like alpha/beta/alpha sandwich fold |
| Homologous_superfamily | IPR036282 | Glutathione S-transferase, C-terminal domain superfamily |
| Homologous_superfamily | IPR037118 | Valyl-tRNA synthetase, tRNA-binding arm superfamily |
Domain Details Per Protein
| Protein | Length | Aminoacyl-tRNA synthetase, class Ia | Aminoacyl-tRNA synthetase, class Ia, anticodon-binding | Aminoacyl-tRNA synthetase, class I, conserved site | Glutathione S-transferase, C-terminal | Glutathione S-transferase, C-terminal domain superfamily | Glutathione S-transferase, C-terminal-like | Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding | Rossmann-like alpha/beta/alpha sandwich fold | Valine-tRNA ligase | Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain | Valyl tRNA synthetase, anticodon-binding domain | Valyl-tRNA synthetase, tRNA-binding arm superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:F1Q740
|
1271 |
Interactions and Pathways
No data available
Plasmids
No data available