Gene
cldnd
- ID
- ZDB-GENE-010328-4
- Name
- claudin d
- Symbol
- cldnd Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable identical protein binding activity. Predicted to be involved in bicellular tight junction assembly and calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules. Predicted to be located in anchoring junction and membrane. Predicted to be active in bicellular tight junction and plasma membrane. Is expressed in gill; gonad; integument; kidney; and muscle. Human ortholog(s) of this gene implicated in ovarian cancer and pancreatic cancer. Orthologous to human CLDN4 (claudin 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu60 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Claudin | Claudin, conserved site | PMP-22/EMP/MP20/Claudin |
|---|---|---|---|---|
|
UniProtKB:Q9YH91
|
208 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-54M16 | ZFIN Curated Data | |
| Encodes | EST | eu60 | Thisse et al., 2005 | |
| Encodes | EST | zf-a310 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:101004 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_180964 (1) | 755 nt | ||
| Genomic | GenBank:CR847847 (1) | 76887 nt | ||
| Polypeptide | UniProtKB:Q9YH91 (1) | 208 aa |
No data available
- Rostam, N., Goloborodko, A., Riemer, S., Hertel, A., Riedel, D., Vorbrüggen, G., Dosch, R. (2022) The germ plasm is anchored at the cleavage furrows through interaction with tight junctions in the early zebrafish embryo. Development (Cambridge, England). 149(15)
- Solis, C.J., Hamilton, M.K., Caruffo, M., Garcia-Lopez, J.P., Navarrete, P., Guillemin, K., Feijoo, C.G. (2020) Intestinal Inflammation Induced by Soybean Meal Ingestion Increases Intestinal Permeability and Neutrophil Turnover Independently of Microbiota in Zebrafish. Frontiers in immunology. 11:1330
- Hou, J., Liu, H., Zhang, S., Liu, X., Hayat, T., Alsaedi, A., Wang, X. (2019) Mechanism of toxic effects of Nano-ZnO on cell cycle of zebrafish (Danio rerio). Chemosphere. 229:206-213
- Schwayer, C., Shamipour, S., Pranjic-Ferscha, K., Schauer, A., Balda, M., Tada, M., Matter, K., Heisenberg, C.P. (2019) Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow. Cell. 179:937-952.e18
- Sun, J., Yan, L., Shen, W., Meng, A. (2018) Maternal Ybx1 safeguards zebrafish oocyte maturation and maternal-to-zygotic transition by repressing global translation. Development (Cambridge, England). 145(19):
- Shu, Y., Lou, Q., Dai, Z., Dai, X., He, J., Hu, W., Yin, Z. (2016) The basal function of teleost prolactin as a key regulator on ion uptake identified with zebrafish knockout models. Scientific Reports. 6:18597
- Sreenivasan, R., Jiang, J., Wang, X., Bartfai, R., Kwan, H.Y., Christoffels, A., and Orban, L. (2014) Gonad Differentiation in Zebrafish Is Regulated by the Canonical Wnt Signaling Pathway. Biology of reproduction. 90(2):45
- Baltzegar, D.A., Reading, B.J., Brune, E.S., and Borski, R.J. (2013) Phylogenetic revision of the claudin gene family. Marine genomics. 11:17-26
- Aanes, H., Winata, C.L., Lin, C.H., Chen, J.P., Srinivasan, K.G., Lee, S.G., Lim, A.Y., Hajan, H.S., Collas, P., Bourque, G., Gong, Z., Korzh, V., Aleström, P., and Mathavan, S. (2011) Zebrafish mRNA sequencing deciphers novelties in transcriptome dynamics during maternal to zygotic transition. Genome research. 21(8):1328-38
- Clelland, E.S., and Kelly, S.P. (2011) Exogenous GDF9 but not Activin A, BMP15 or TGFβ alters tight junction protein transcript abundance in zebrafish ovarian follicles. General and comparative endocrinology. 171(2):211-217
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