Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-001103-4
Gene Name: cytochrome P450, family 19, subfamily A, polypeptide 1b
Gene Symbol: cyp19a1b
Previous Names: AroB (2), CYP19a2 (1), cyp19b (2), aromatase B (1), brain aromatase (1), P450aromB, zgc:92614
Location: Chr: 25   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 56 figures from 22 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
  anterior lateral line nerve, brain, caudal parvocellular preoptic nucleus, caudal periventricular hypothalamus (all 57) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Alleles: sa24593
PHENOTYPE
Phenotype of Human Orthologue OMIM Phenotype ID
Aromatase deficiency 613546
Aromatase excess syndrome 139300
GENE ONTOLOGY
Ontology GO Term
Biological Process response to estradiol (more)
Molecular Function heme binding (more)
GO Terms (all 11)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001128 (1)
  • InterPro:IPR002401 (1)
  • InterPro:IPR017972 (1)
  • PROSITE:PS00086 (1)
  • Pfam:PF00067 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA cyp19a1b-001 (1) 4167
    GENE PRODUCT DESCRIPTION
    ANTIBODIES
    AB1-cyp19a1b (1)
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cyp19a1b
    Tg(cyp19a1b:cyp19a1b-GFP)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    cyp19a1b Contained in: [BAC] CH211-286K11 (1) (order this)
    cyp19a1b Encodes: [cDNA] MGC:92614 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131642 (1) 3809 bp
    Genomic GenBank:AL954697 (1) 134798 bp
    Select Tool
    Polypeptide UniProtKB:Q5U870 (1) 511 aa
    Sequence Clusters UniGene:10461 (1)
    Sequence Information (all 23)
    OTHER cyp19a1b GENE PAGES
  • Gene:60640 (1)
  • VEGA:OTTDARG00000021147 (1)
  • Ensembl(Zv9):ENSDARG00000009852 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish cyp19a1b 25  
    Human CYP19A1 15 (15q21.1)
  • OMIM:107910
  • Gene:1588
  • Mouse Cyp19a1 9 ( 29.49 cM)
  • MGI:88587
  • Gene:13075
  • Orthology Details
    CITATIONS (98)