Gene
hoxb6b
- ID
- ZDB-GENE-000823-7
- Name
- homeobox B6b
- Symbol
- hoxb6b Nomenclature History
- Previous Names
-
- hoxa7
- z-5
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anterior/posterior pattern specification and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in several structures, including margin; mesoderm; nervous system; tail bud; and trunk. Orthologous to human HOXB6 (homeobox B6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 18 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu750 (25 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sud137 | Allele with one deletion | Exon 1 | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-hoxb6b | Maeno et al., 2024 | |
| MO1-hoxb6b | N/A | Sundaramoorthi et al., 2023 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Antennapedia-type homeobox | Homedomain-like superfamily | Homeobox, conserved site | Homeobox protein, antennapedia type | Homeobox protein, antennapedia type, conserved site | Homeodomain | Homeodomain, metazoa |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:B3DHS2 | InterPro | 224 | |||||||
| UniProtKB:Q9YGT4 | InterPro | 224 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
hoxb6b-201
(1)
|
Ensembl | 1,194 nt | ||
| mRNA | ottdart00000001799 (1) | Havana | 1,007 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-11C5 | ZFIN Curated Data | |
| Contained in | PAC | BUSM1-227H09 | (2) | |
| Encodes | EST | eu750 | Thisse et al., 2005 | |
| Encodes | cDNA | MGC:194274 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194296 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131538 (1) | 987 nt | ||
| Genomic | GenBank:BX001014 (1) | 193523 nt | ||
| Polypeptide | UniProtKB:B3DHS2 (1) | 224 aa |
- Maeno, A., Koita, R., Nakazawa, H., Fujii, R., Yamada, K., Oikawa, S., Tani, T., Ishizaka, M., Satoh, K., Ishizu, A., Sugawara, T., Adachi, U., Kikuchi, M., Iwanami, N., Matsuda, M., Kawamura, A. (2024) Hox code responsible for the pattering of the anterior vertebrae in zebrafish. Development (Cambridge, England). 151(14):
- Sundaramoorthi, H., Fallatah, W., Mary, J., Jagadeeswaran, P. (2023) Discovery of seven hox genes in zebrafish thrombopoiesis. Blood cells, molecules & diseases. 104:102796102796
- Yamada, K., Maeno, A., Araki, S., Kikuchi, M., Suzuki, M., Ishizaka, M., Satoh, K., Akama, K., Kawabe, Y., Suzuki, K., Kobayashi, D., Hamano, N., Kawamura, A. (2021) An atlas of seven zebrafish hox cluster mutants provides insights into sub/neofunctionalization of vertebrate Hox clusters. Development (Cambridge, England). 148(11):
- Pak, B., Schmitt, C.E., Choi, W., Kim, J.D., Han, O., Alsiö, J., Jung, D.W., Williams, D.R., Coppieters, W., Stainier, D.Y.R., Jin, S.W. (2020) Analyses of Avascular Mutants Reveal Unique Transcriptomic Signature of Non-conventional Endothelial Cells. Frontiers in cell and developmental biology. 8:589717
- Zhang, C., Featherstone, M. (2020) A zebrafish hox gene acts before gastrulation to specify the hemangioblast. Genesis (New York, N.Y. : 2000). 58(6):e23363
- Malmstrøm, M., Britz, R., Matschiner, M., Tørresen, O.K., Hadiaty, R.K., Yaakob, N., Tan, H.H., Jakobsen, K.S., Salzburger, W., Rüber, L. (2018) The Most Developmentally Truncated Fishes Show Extensive Hox Gene Loss and Miniaturized Genomes. Genome biology and evolution. 10:1088-1103
- Wang, J., Fei, F., Berberoglu, M.A., Sun, S., Wang, L., Dong, Z., Wang, X. (2018) Csy4-based vector system enables conditional chimeric gene editing in zebrafish without interrupting embryogenesis. Journal of molecular cell biology. 10(6):586-588
- Barsh, G.R., Isabella, A.J., Moens, C.B. (2017) Vagus Motor Neuron Topographic Map Determined by Parallel Mechanisms of hox5 Expression and Time of Axon Initiation. Current biology : CB. 27(24):3812-3825.e3
- Hayward, A.G., Joshi, P., Skromne, I. (2015) Spatiotemporal analysis of zebrafish hox gene regulation by Cdx4. Developmental Dynamics : an official publication of the American Association of Anatomists. 244(12):1564-73
- Mitchell, D.M., Stevens, C.B., Frey, R.A., Hunter, S.S., Ashino, R., Kawamura, S., Stenkamp, D.L. (2015) Retinoic Acid Signaling Regulates Differential Expression of the Tandemly-Duplicated Long Wavelength-Sensitive Cone Opsin Genes in Zebrafish. PLoS Genetics. 11:e1005483
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