ZFIN ID: ZDB-GENE-000705-1
Gene Name: kinase insert domain receptor like
Gene Symbol: kdrl
Previous Names: kdr, kdra (1), fetal liver kinase, fk52c05, flk-1, flk1 (1), flk, flt1b (1), VEGFR-2 (1), vegfr2, vegfr4, vegr2, wu:fk52c05
Location: Chr: 14 Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 233 figures from 165 publications
Directly Submitted Expression Data: 6 figures (27 images) from Thisse et al., 2008 [cssl:d0146]
Wild-type Stages, Structures: Blastula:1k-cell (3.0h-3.33h) to Larval:Days 7-13 (168.0h-14d, 4.5mm, 8 teeth)
  anatomical structure, angioblastic mesenchymal cell, angiogenic sprout, anterior lateral mesoderm (all 98) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Mutagen Suppliers
hu5088 Point Mutation ENU
la010852Tg Transgenic Insertion DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la018984Tg Transgenic Insertion DNA
    la027548Tg Transgenic Insertion DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa9469 Point Mutation ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa15912 Point Mutation ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • t20257 Point Mutation ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • t21588 Point Mutation ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • um6 Point Mutation ENU
    um19 Small Deletion ZINC_FINGER_NUCLEASE
    y17 Point Mutation ENU
    Targeting reagents: MO1-kdrl (1), MO2-kdrl (1), MO3-kdrl (1), MO4-kdrl (1), MO5-kdrl (1)
    PHENOTYPE
    Data: 15 figures from 9 publications
    Observed in: angiogenesis, artery morphogenesis, blood circulation, blood vasculature (all 15) expand
    DISEASE ASSOCIATED WITH kdrl HUMAN ORTHOLOGNo data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process angiogenesis (more)
    Cellular Component integral component of membrane (more)
    Molecular Function protein tyrosine kinase activity (more)
    GO Terms (all 22)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000719 (1)
  • InterPro:IPR001245 (1)
  • InterPro:IPR001824 (1)
  • InterPro:IPR003598 (1)
  • InterPro:IPR003599 (1)
  • InterPro:IPR007110 (1)
  • InterPro:IPR008266 (1)
  • InterPro:IPR011009 (1)
  • InterPro:IPR013098 (1)
  • InterPro:IPR013151 (1)
  • InterPro:IPR013783 (1)
  • InterPro:IPR017441 (1)
  • InterPro:IPR020635 (1)
  • PROSITE:PS00107 (1)
  • PROSITE:PS00109 (1)
  • PROSITE:PS00240 (1)
  • PROSITE:PS50011 (1)
  • PROSITE:PS50835 (1)
  • Pfam:PF00047 (1)
  • Pfam:PF07679 (1)
  • Pfam:PF07714 (1)
  • EC:2.7.10.1 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA kdrl-001 (1) 5790
    GENE PRODUCT DESCRIPTION
    ANTIBODIES
    Ab1-kdrl (1)
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM kdrl
    Tg(-6.5kdrl:mCherry), Tg(-6.5kdrl:NLS-mCherry), Tg(kdrl:Cerulean), Tg(kdrl:CFP), Tg(kdrl:copGFP) (all 53) expand
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    kdrlContained in: [BAC] CH211-231B5 (1) (order this), CH211-276G21 (1) (order this), DKEY-1A23 (1) (order this), DKEY-183E23 (1) (order this)
    kdrlEncodes: [EST] cssl:d0146 (1) (order this), fk52c05
    [cDNA] MGC:158203 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131472 (1) 3906bp
    Genomic GenBank:CR759732 (1) 225630bp Blast at MegaBLAST
    Polypeptide UniProtKB:Q8AXB3 (1) 1302aa
    Sequence Clusters UniGene:75094 (1)
    Sequence Information (all 37)
    OTHER kdrl GENE PAGES
  • Gene:796537 (1)
  • VEGA:OTTDARG00000031823 (1)
  • Ensembl(GRCz10):ENSDARG00000105215 (1)
  • ORTHOLOGY for kdrl (Chr: 14)No data available
    CITATIONS (376)