Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-000705-1
Gene Name: kinase insert domain receptor like
Gene Symbol: kdrl
Previous Names: kdr, kdra (1), fetal liver kinase, fk52c05, flk, flk-1, flk1 (1), flt1b (1), VEGFR-2 (1), vegfr2, vegfr4, vegr2, wu:fk52c05
Location: Chr: 14   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 201 figures from 141 publications
Directly Submitted Expression Data: 6 figures (27 images) from Thisse et al., 2008 [cssl:d0146]
Wild-type Stages, Structures: Blastula:1k-cell (3.0h-3.33h) to Larval:Days 7-13 (168.0h-14d, 4.5mm, 8 teeth)
  angioblastic mesenchymal cell, angiogenic sprout, anterior lateral mesoderm, anterior lateral mesoderm endothelial cell (all 80) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 17 genotypes
Alleles: hu5088, la010852Tg, la018984Tg, la027548Tg, sa15912 (all 11) expand
Knockdown reagents: MO1-kdrl (1), MO2-kdrl (1), MO3-kdrl (1), MO4-kdrl (1)
PHENOTYPE
Data: 10 figures from 7 publications
Observed in: angiogenesis, artery morphogenesis, blood circulation, blood vasculature (all 12) expand
GENE ONTOLOGY
Ontology GO Term
Biological Process peptidyl-tyrosine phosphorylation (more)
Cellular Component integral component of membrane (more)
Molecular Function protein tyrosine kinase activity (more)
GO Terms (all 24)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000719 (1)
  • InterPro:IPR001245 (1)
  • InterPro:IPR001824 (1)
  • InterPro:IPR003598 (1)
  • InterPro:IPR003599 (1)
  • InterPro:IPR007110 (1)
  • InterPro:IPR008266 (1)
  • InterPro:IPR011009 (1)
  • InterPro:IPR013098 (1)
  • InterPro:IPR013783 (1)
  • InterPro:IPR017441 (1)
  • InterPro:IPR020635 (1)
  • PROSITE:PS00107 (1)
  • PROSITE:PS00109 (1)
  • PROSITE:PS00240 (1)
  • PROSITE:PS50011 (1)
  • PROSITE:PS50835 (1)
  • Pfam:PF07679 (1)
  • Pfam:PF07714 (1)
  • EC:2.7.10.1 (1)
  •  Withdrawn Transcriptsextinct
    GENE PRODUCT DESCRIPTION
    ANTIBODIES
    Ab1-kdrl (1)
    CONSTRUCTS WITH SEQUENCES FROM kdrl
    Tg(-6.5kdrl:mCherry), Tg(-6.5kdrl:NLS-mCherry), Tg(kdrl:Cerulean), Tg(kdrl:CFP), Tg(kdrl:copGFP) (all 39) expand
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    kdrl Contained in: [BAC] CH211-231B5 (1) (order this), CH211-276G21 (1) (order this), DKEY-183E23 (1)
    kdrl Encodes: [EST] cssl:d0146 (1) (order this), fk52c05
    [cDNA] MGC:158203 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131472 (1) 3906 bp
    Genomic GenBank:CR759732 (1) 225630 bp Blast at MegaBLAST
    Polypeptide UniProtKB:Q8AXB3 (1) 1302 aa
    Sequence Clusters UniGene:75094 (1)
    Sequence Information (all 34)
    OTHER kdrl GENE PAGES
  • Gene:796537 (1)
  • Ensembl(Zv9):ENSDARG00000015815 (1)
  • ORTHOLOGY No data available
    CITATIONS (305)