ZFIN ID: ZDB-GENE-000705-1
Gene Name: kinase insert domain receptor like
Gene Symbol: kdrl
Previous Names: kdr, kdra (1), fetal liver kinase, fk52c05, flk-1, flk1 (1), flk, flt1b (1), VEGFR-2 (1), vegfr2, vegfr4, vegr2, wu:fk52c05
Location: Chr: 14   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 214 figures from 152 publications
Directly Submitted Expression Data: 6 figures (27 images) from Thisse et al., 2008 [cssl:d0146]
Wild-type Stages, Structures: Blastula:1k-cell (3.0h-3.33h) to Larval:Days 7-13 (168.0h-14d, 4.5mm, 8 teeth)
  angioblastic mesenchymal cell, angiogenic sprout, anterior lateral mesoderm, anterior lateral mesoderm endothelial cell (all 92) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 17 Genotypes
Knockdown reagents: MO1-kdrl (1), MO2-kdrl (1), MO3-kdrl (1), MO4-kdrl (1), MO5-kdrl (1)

Allele Type Mutagen Suppliers
hu5088 Point Mutation ENU
la010852Tg Transgenic Insertion DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la018984Tg Transgenic Insertion DNA
    la027548Tg Transgenic Insertion DNA
    sa9469 Point Mutation ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  •    expand Show all 11 alleles
    PHENOTYPE
    Data: 14 figures from 8 publications
    Observed in: angiogenesis, artery morphogenesis, blood circulation, blood vasculature (all 15) expand
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process angiogenesis (more)
    Cellular Component integral component of membrane (more)
    Molecular Function protein tyrosine kinase activity (more)
    GO Terms (all 23)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000719 (1)
  • InterPro:IPR001245 (1)
  • InterPro:IPR001824 (1)
  • InterPro:IPR003598 (1)
  • InterPro:IPR003599 (1)
  • InterPro:IPR007110 (1)
  • InterPro:IPR008266 (1)
  • InterPro:IPR011009 (1)
  • InterPro:IPR013098 (1)
  • InterPro:IPR013783 (1)
  • InterPro:IPR017441 (1)
  • InterPro:IPR020635 (1)
  • PROSITE:PS00107 (1)
  • PROSITE:PS00109 (1)
  • PROSITE:PS00240 (1)
  • PROSITE:PS50011 (1)
  • PROSITE:PS50835 (1)
  • Pfam:PF07679 (1)
  • Pfam:PF07714 (1)
  • EC:2.7.10.1 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA kdrl-001 (1) 5790
    GENE PRODUCT DESCRIPTION
    ANTIBODIES
    Ab1-kdrl (1)
    PLASMIDS
    Addgene
    CONSTRUCTS WITH SEQUENCES FROM kdrl
    Tg(-6.5kdrl:mCherry), Tg(-6.5kdrl:NLS-mCherry), Tg(kdrl:Cerulean), Tg(kdrl:CFP), Tg(kdrl:copGFP) (all 44) expand
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    kdrl Contained in: [BAC] CH211-231B5 (1) (order this), CH211-276G21 (1) (order this), DKEY-1A23 (1) (order this), DKEY-183E23 (1) (order this)
    kdrl Encodes: [EST] cssl:d0146 (1) (order this), fk52c05
    [cDNA] MGC:158203 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131472 (1) 3906 bp
    Genomic GenBank:CR759732 (1) 225630 bp Blast at MegaBLAST
    Polypeptide UniProtKB:Q8AXB3 (1) 1302 aa
    Sequence Clusters UniGene:75094 (1)
    Sequence Information (all 36)
    OTHER kdrl GENE PAGES
  • Gene:796537 (1)
  • VEGA:OTTDARG00000031823 (1)
  • Ensembl(Zv9):ENSDARG00000015815 (1)
  • ORTHOLOGY No data available
    CITATIONS (325)