ZFIN ID: ZDB-GENE-000705-1
Gene Name: kinase insert domain receptor like
Gene Symbol: kdrl
Previous Names: kdr, kdra (1), fetal liver kinase, flk-1, flk1 (1), flk, flt1b (1), VEGFR-2 (1), vegfr2, vegfr2a (1), vegfr4, vegr2, wu:fk52c05
Location: Chr: 14 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 240 figures from 171 publications
Directly Submitted Expression Data: 6 figures (27 images) from Thisse et al., 2008 [cssl:d0146]
Wild-type Stages, Structures: Blastula:1k-cell (3.0h-3.33h) to Adult (90d-730d, breeding adult)
  anatomical structure, angioblastic mesenchymal cell, angiogenic sprout, anterior lateral mesoderm (all 101) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu5088 Point Mutation Unknown Unknown ENU
ihb123 Small Deletion Unknown Unknown CRISPR
la010852Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la018984Tg Transgenic Insertion Unknown Unknown DNA
    la027548Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa9469 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa15912 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • t20257 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • t21588 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • um6 Point Mutation Unknown Unknown ENU
    um19 Small Deletion Exon 2 Frameshift ZINC_FINGER_NUCLEASE
    y17 Point Mutation Unknown Unknown ENU
    Targeting reagents: CRISPR1-kdrl (1), MO1-kdrl (1), MO2-kdrl (1), MO3-kdrl (1), MO4-kdrl (1) (all 6) expand
    PHENOTYPE
    Data: 16 figures from 10 publications
    Observed in: angiogenesis, artery morphogenesis, blood circulation, blood vasculature (all 17) expand
    DISEASE ASSOCIATED WITH kdrl HUMAN ORTHOLOGNo data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process angiogenesis (more)
    Cellular Component integral component of membrane (more)
    Molecular Function protein tyrosine kinase activity (more)
    GO Terms (all 22)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000719 (1)
  • InterPro:IPR001245 (1)
  • InterPro:IPR001824 (1)
  • InterPro:IPR003598 (1)
  • InterPro:IPR003599 (1)
  • InterPro:IPR007110 (1)
  • InterPro:IPR008266 (1)
  • InterPro:IPR011009 (1)
  • InterPro:IPR013098 (1)
  • InterPro:IPR013151 (1)
  • InterPro:IPR013783 (1)
  • InterPro:IPR017441 (1)
  • InterPro:IPR020635 (1)
  • PROSITE:PS00107 (1)
  • PROSITE:PS00109 (1)
  • PROSITE:PS00240 (1)
  • PROSITE:PS50011 (1)
  • PROSITE:PS50835 (1)
  • Pfam:PF00047 (1)
  • Pfam:PF07679 (1)
  • Pfam:PF07714 (1)
  • EC:2.7.10.1 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA kdrl-001 (1) 5790
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES
    Ab1-kdrl (1)
    PLASMIDS
    Addgene
    CONSTRUCTS WITH SEQUENCES FROM kdrl
    Tg(-6.5kdrl:mCherry), Tg(-6.5kdrl:NLS-mCherry), Tg(kdrl:Cerulean), Tg(kdrl:CFP), Tg(kdrl:copGFP) (all 56) expand
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    kdrlContained in: [BAC] CH211-231B5 (1) (order this), CH211-276G21 (1) (order this), DKEY-1A23 (1) (order this), DKEY-183E23 (1) (order this)
    kdrlEncodes: [EST] cssl:d0146 (1) (order this), fk52c05
    [cDNA] MGC:158203 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131472 (1) 3906bp
    Genomic GenBank:CR759732 (1) 225630bp Blast at MegaBLAST
    Polypeptide UniProtKB:Q8AXB3 (1) 1302aa
    Sequence Clusters UniGene:75094 (1)
    Sequence Information (all 39)
    OTHER kdrl GENE PAGES
  • Gene:796537 (1)
  • VEGA:OTTDARG00000031823 (1)
  • Ensembl(GRCz10):ENSDARG00000105215 (1)
  • ORTHOLOGY for kdrl (Chr: 14)No data available
    CITATIONS (396)