ZFIN ID: ZDB-GENE-000705-1
Gene Name: kinase insert domain receptor like
Gene Symbol: kdrl
Previous Names: kdr, kdra (1), fetal liver kinase, fk52c05, flk-1, flk1 (1), flk, flt1b (1), VEGFR-2 (1), vegfr2, vegfr4, vegr2, wu:fk52c05
Location: Chr: 14   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 212 figures from 150 publications
Directly Submitted Expression Data: 6 figures (27 images) from Thisse et al., 2008 [cssl:d0146]
Wild-type Stages, Structures: Blastula:1k-cell (3.0h-3.33h) to Larval:Days 7-13 (168.0h-14d, 4.5mm, 8 teeth)
  angioblastic mesenchymal cell, angiogenic sprout, anterior lateral mesoderm, anterior lateral mesoderm endothelial cell (all 83) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 17 Genotypes
Alleles: hu5088, la010852Tg, la018984Tg, la027548Tg, sa15912 (all 11) expand
Knockdown reagents: MO1-kdrl (1), MO2-kdrl (1), MO3-kdrl (1), MO4-kdrl (1), MO5-kdrl (1)
PHENOTYPE
Data: 14 figures from 8 publications
Observed in: angiogenesis, artery morphogenesis, blood circulation, blood vasculature (all 15) expand
GENE ONTOLOGY
Ontology GO Term
Biological Process angiogenesis (more)
Cellular Component integral component of membrane (more)
Molecular Function protein tyrosine kinase activity (more)
GO Terms (all 23)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000719 (1)
  • InterPro:IPR001245 (1)
  • InterPro:IPR001824 (1)
  • InterPro:IPR003598 (1)
  • InterPro:IPR003599 (1)
  • InterPro:IPR007110 (1)
  • InterPro:IPR008266 (1)
  • InterPro:IPR011009 (1)
  • InterPro:IPR013098 (1)
  • InterPro:IPR013783 (1)
  • InterPro:IPR017441 (1)
  • InterPro:IPR020635 (1)
  • PROSITE:PS00107 (1)
  • PROSITE:PS00109 (1)
  • PROSITE:PS00240 (1)
  • PROSITE:PS50011 (1)
  • PROSITE:PS50835 (1)
  • Pfam:PF07679 (1)
  • Pfam:PF07714 (1)
  • EC:2.7.10.1 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA ottdart00000026879 (1) 5790
    GENE PRODUCT DESCRIPTION
    ANTIBODIES
    Ab1-kdrl (1)
    PLASMIDS
    Addgene
    CONSTRUCTS WITH SEQUENCES FROM kdrl
    Tg(-6.5kdrl:mCherry), Tg(-6.5kdrl:NLS-mCherry), Tg(kdrl:Cerulean), Tg(kdrl:CFP), Tg(kdrl:copGFP) (all 43) expand
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    kdrl Contained in: [BAC] CH211-231B5 (1) (order this), CH211-276G21 (1) (order this), DKEY-1A23 (1) (order this), DKEY-183E23 (1) (order this)
    kdrl Encodes: [EST] cssl:d0146 (1) (order this), fk52c05
    [cDNA] MGC:158203 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131472 (1) 3906 bp
    Genomic GenBank:CR759732 (1) 225630 bp Blast at MegaBLAST
    Polypeptide UniProtKB:Q8AXB3 (1) 1302 aa
    Sequence Clusters UniGene:75094 (1)
    Sequence Information (all 36)
    OTHER kdrl GENE PAGES
  • Gene:796537 (1)
  • Ensembl(Zv9):ENSDARG00000015815 (1)
  • ORTHOLOGY No data available
    CITATIONS (321)