Gene
dct
- ID
- ZDB-GENE-000508-1
- Name
- dopachrome tautomerase
- Symbol
- dct Nomenclature History
- Previous Names
-
- TRP-2
- trp2
- tyrosinase-related protein-2
- zgc:109860
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable dopachrome isomerase activity. Acts upstream of or within melanin metabolic process. Predicted to be located in melanosome membrane. Predicted to be active in melanosome. Is expressed in several structures, including eye; female organism; immature eye; integument; and neural crest. Used to study oculocutaneous albinism. Human ortholog(s) of this gene implicated in oculocutaneous albinism. Orthologous to human DCT (dopachrome tautomerase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 103 figures from 76 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Pennamen et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la016638Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa21611 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa34785 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Oculocutaneous albinism, type VIII | 619165 |
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| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| oculocutaneous albinism | WT + MO1-dct | standard conditions | Pennamen et al., 2020 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Di-copper centre-containing domain superfamily | Tyrosinase and Hemocyanin | Tyrosinase copper-binding domain |
|---|---|---|---|---|
|
UniProtKB:A1L1Y0
|
513 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-495O7 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:109860 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:158512 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191397 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131555 (1) | 1884 nt | ||
| Genomic | GenBank:CU694472 (2) | 32900 nt | ||
| Polypeptide | UniProtKB:A1L1Y0 (1) | 513 aa |
- Watai, K., Sadamitsu, K., Wada, S., Kashima, M., Hirata, H. (2024) Zebrafish trpm7 mutants show reduced motility in free movement. Development, growth & differentiation. 66(6):349-356
- Bian, W.P., Xie, S.L., Wang, C., Martinovich, G.G., Ma, Y.B., Jia, P.P., Pei, D.S. (2023) mitfa deficiency promotes immune vigor and potentiates antitumor effects in zebrafish. Fish & shellfish immunology. 142:109130
- Lumaquin-Yin, D., Montal, E., Johns, E., Baggiolini, A., Huang, T.H., Ma, Y., LaPlante, C., Suresh, S., Studer, L., White, R.M. (2023) Lipid droplets are a metabolic vulnerability in melanoma. Nature communications. 14:31923192
- Luo, L., Jia, W., Zhang, Y., Guo, Y., Zhu, J., Li, C. (2023) Proprotein Convertase Furin Regulates Melanogenesis via the Notch Signaling Pathway. Discovery medicine. 35:144156144-156
- Vöcking, O., Famulski, J.K. (2023) A temporal single cell transcriptome atlas of zebrafish anterior segment development. Scientific Reports. 13:56565656
- Kenny, C., Dilshat, R., Seberg, H.E., Van Otterloo, E., Bonde, G., Helverson, A., Franke, C.M., Steingrímsson, E., Cornell, R.A. (2022) TFAP2 paralogs facilitate chromatin access for MITF at pigmentation and cell proliferation genes. PLoS Genetics. 18:e1010207
- Maskin, C.R., Raman, R., Houvras, Y. (2022) PPP6C, a serine-threonine phosphatase, regulates melanocyte differentiation and contributes to melanoma tumorigenesis through modulation of MITF activity. Scientific Reports. 12:5573
- Neuffer, S.J., Beltran-Cardona, D., Jimenez-Perez, K., Clancey, L.F., Brown, A., New, L., Cooper, C.D. (2022) AP-3 complex delta subunit gene, ap3d1, regulates melanogenesis and melanophore survival via autophagy in zebrafish (Danio rerio). Pigment cell & melanoma research. 35(5):495-505
- Xia, Z., Yang, X., Bi, X., Tong, X., Min, J., Wang, F. (2022) Zinc transporter Slc30a1 regulates melanocyte development by interacting with mt2 in zebrafish. European journal of cell biology. 101:151272
- Yue, Y., Zhong, M., An, X., Feng, Q., Lai, Y., Yu, M., Zhang, X., Liao, Z., Chen, M., Dong, J., Zhong, H., Shang, J. (2022) Serotonin (5-HT) 2A Receptor Involvement in Melanin Synthesis and Transfer via Activating the PKA/CREB Signaling Pathway. International Journal of Molecular Sciences. 23(11)
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